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Undergraduate Institution and Major/Degree:
- Peking University, Basic Medical Sciences/ Bachelor of Medicine
Graduate Major Advisor(s):
Graduate Research Description:
Endomorphin-2 (EM-2) is an endogenous ligand for 5-opioid receptor. It has been reported that EM-2 is present in many brain regions including the periaqueductal gray (PAG), the rostral ventromedial medulla (RVM) and spinal cord dorsal horn, all of which play important roles in the descending pathway mediated both stimulation-produced analgesia and opioid-produced analgesia.
My research interest is focused on the relationship of EM-2-immunoreactive axons to the neurons in PAG-RVM-spinal cord circuitry. Fluorescent retrograde tract-tracing combining immunocytochemical staining and light microscopy are used to examine with what populations of neurons EM-2 fibers interact with in the PAG and RVM and whether the EM-2 fibers are from the nucleus of the solitary tract (NTS) / hypothalamus. I am also interested in the analgesic role the endogenous EM-2 plays. The antibody microprobes with behavior analysis will be used to examine whether the endogenous EM-2 has a function mediated with the stimulation-produced analgesia.
Graduate Lab Rotations:
- Water Low
- Alice Larson
- Martin Wessendorf
- Alvin Beitz
Graduate Courses Taken Beyond the Core Courses:
- Biostatistical Methods I
- Theory of Statistics I
- Analysis of Categorical Data
- Theory of Statistics II
- Neurosci Drug Abuse
- Neurobiol pain
Conferences Attended and Presentations:
- Society for Neuroscience annual meeting - Fall 2001, 2003, 2004 (presented poster in 2003, 2004)
- ( Pain annual meeting-Summer 2004 (presented poster)
Graduate Committee Members:
- David Brown - Chair
- Alvin Beitz
- Christopher Honda
- Donald Simone
- Martin Wessendorf
Selected Publications and Presentations:
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M Gu, MW. Wessendorf. Endomorphin-2-immunoreactive fibers selectively appose serotonergic neuronal somata in the rostral ventral medial medulla. J. Comp Neurol (accepted).
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M Gu, MW.Wessendorf. ENDOMORPHIN-2-IMMUNOREACTIVE FIBERS SELECTIVELY APPOSE SEROTONERGIC NEURONAL SOMATA IN THE RVM. Society for Neuroscience National Meeting, 2004
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M Gu, MW.Wessendorf. ENDOMORPHIN-2-IMMUNOREACTIVE FIBERS ARE APPOSED BOTH TO RVM-PROJECTING NEURONS AND NON-PROJECTING NEURONS IN THE PAG . Society for Neuroscience National Meeting, 2003
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M Gu, XM Wang, DEVELOPMENT IN THE RESEARCH OF MOLECULAR MECHANISM OF ALZHEIMER'S DISEASE. Chinese Science Bulletin, Vol 44, No 14, 1999
Awards and Honors:
- University of Minnesota Pre-Doctoral Fellowship, 2001-2002
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