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David Linden Ph.D. 1999 Thesis Title: The Role of Spinal Neurokinin 3 Receptors in Processing Nociceptin Information Advisor: Virginia Seybold

Honors:

Bacaner Award

Thesis Publications:

Linden DR, Reutter MA, McCarson KE, Seybold VS. (2000) Time-dependent changes in neurokinin(3) receptors and tachykinins during adjuvant-induced peripheral inflammation in the rat. Neuroscience 98:801-811.

Linden DR, Chell MJ, El-Fakahany EE, Seybold VS. (2000) Neurokinin(3) receptors couple to the activation of neuronal nitric-oxide synthase in stably transfected Chinese hamster ovary cells. J Pharmacol Exp Ther 293:559-568.

Linden, DR, Jia, Y-P, Seybold, VS (1999) Spinal NK3 receptors increase the nociceptive flexor reflex via a pathway involving nitric oxide. Pain 80:301-308.

Linden, DR, Seybold, VS (1999) Spinal NK3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide. Pain 80:309-318.

Jia, Y-P, Linden, DR, Serie, JR, Seybold, VS (1998) Nociceptin/Orphanin FQ binding increases in superficial laminae of the rat spinal cord during persistent peripheral inflammation. Neurosci Lett. 250:21-24.

Other Publications:

Krauter EM, Linden DR, Sharkey KA, Mawe GM. Synaptic plasticity in myenteric neurons of the guinea-pig distal colon: presynaptic mechanisms of inflammation-induced synaptic facilitation.J Physiol. 2007 Jun 1;581(Pt 2):787-800.

Lomax AE, Linden DR, Mawe GM, Sharkey KA. Effects of gastrointestinal inflammation on enteroendocrine cells and enteric neural reflex circuits. Auton Neurosci. 2006 Jun 30;126-127:250-7.

Linden DR, Couvrette JM, Ciolino A, McQuoid C, Blaszyk H, Sharkey KA, Mawe GM. Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon. Neurogastroenterol Motil. 2005 Oct;17(5):751-60. Erratum in: Neurogastroenterol Motil. 2005 Dec;17(6

Linden, DR, Foley, KF, McQuoid, C, Simpson, J, Mawe, GM, (2005) Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis. Neurogastoenerol. Mot.17:565-574.

Linden, DR, Sharkey, KA, Ho, W, Mawe, GM (2004) Cyclooxygenase-2 contributes to dysmotility and enhanced excitability of myenteric AH neurons in the inflamed guinea pig distal colon. J. Physiol. 557:191-205.

Coates, MD, Mahoney, CR, Linden, DR, Sampson, JE, Chen, J, Blaszyk, H, Crowell, MD, Sharkey KA, Gershon, MD, Mawe, GM, Moses, PL (2004) Molecular defects in serotonin signaling in the mucosa of the human colon: decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 126:1657-1664.

O’Hara, JR, Ho, W, Linden, DR, Mawe, GM Sharkey, KA, (2004) Enteroendocrine cells and serotonin availability are altered in the mucosa of guinea pigs with TNBS ileitis. Am. J. Physiol. Gastrointest. Liver Physiol. 287:G998-G1007.

Linden DR. Colitis: it is not just for the colon anymore. Br J Pharmacol. 2003 May;139(2):185-6.

Linden DR, Chen JX, Gershon MD, Sharkey KA, Mawe GM. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G207-16.

Linden DR , Sharkey KA, Mawe GM. Enhanced excitability of myenteric AH neurones in the inflamed guinea-pig distal colon. J Physiol. 2003 Mar 1;547(Pt 2):589-601. Epub 2003 Jan 24.

Linden DR , el-Fakahany EE. Arachidonic acid inhibition of muscarinic receptor-mediated nitric oxide production occurs at the level of calcium mobilization in Chinese hamster ovary cells. Neurochem Res. 2002 Jun;27(6):441-9.

Linden DR , El-Fakahany EE. Microglial derived nitric oxide decreases serotonin content in rat basophilic leukemia (RBL-2H3) cells. Eur J Pharmacol. 2002 Feb 1;436(1-2):53-6.

Linden DR , Manning BP, Bunnett NW, Mawe GM. Agonists of proteinase-activated receptor 2 excite guinea pig ileal myenteric neurons. Eur J Pharmacol. 2001 Nov 23;431(3):311-4.

Linden DR , Seybold VS. Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide. Pain. 1999 Mar;80(1-2):309-17.

Jia Y, Linden DR , Serie JR, Seybold VS. Nociceptin/orphanin FQ binding increases in superficial laminae of the rat spinal cord during persistent peripheral inflammation. Neurosci Lett. 1998 Jun 26;250(1):21-4.