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Ann Parsons Ph.D. 1996 Thesis Title: Spinal Neurokinin and Calcitonin Gene-Related Peptide Receptors and their Role in Hyperalgesia Advisor: Virginia Seybold

Thesis Publications:

Parsons, A.M., E.E. El-Fakahany, and V.S. Seybold. (1995) Tachykinins alter inositol phosphate formation, but not cAMP levels, in neonatal rat spinal neurons through activation of neurokinin receptors. Neuroscience 68:855-865.

Parsons AM, Honda CN, Jia YP, Budai D, Xu XJ, Wiesenfeld-Hallin Z, Seybold VS. (1996) Spinal NK1 receptors contribute to the increased excitability of the nociceptive flexor reflex during persistent peripheral inflammation. Brain Res 739:263-275.

Parsons AM, Seybold VS. (1997) Calcitonin gene-related peptide induces the formation of second messengers in primary cultures of neonatal rat spinal cord. Synapse 26:235-242.

Other Publications:

Christopoulos A, Parsons AM, Lew MJ, El-Fakahany EE. (1999) The assessment of antagonist potency under conditions of transient response kinetics. Eur J Pharmacol 382:217-227.

Christopoulos A, Parsons AM, El-Fakahany EE. Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor. J Pharmacol Exp Ther. 1999 Jun;289(3):1220-8.

Parsons AM, Sorman JL, El-Fakahany EE. Regulation of M1 muscarinic receptor-mediated signaling in intact cells by exogenous, but not endogenously produced, nitric oxide. Neurochem Res. 1999 Jan;24(1):85-94.

Wotta DR , Parsons AM, Hu J, Grande AW, El-Fakahany EE. M1 muscarinic receptors stimulate rapid and prolonged phases of neuronal nitric oxide synthase activity: involvement of different calcium pools. J Neurochem. 1998 Aug;71(2):487-97.

Wang SZ, Lee SY, Zhu SZ, Wotta DR, Parsons AM, el-Fakahany EE. Activation of neuronal nitric oxide synthase by M2 muscarinic receptors associated with a small increase in intracellular calcium. Pharmacology. 1997 Jul;55(1):10-7.