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Laura Stone Ph.D. 1999 Thesis Title: Alpha-2 Adrenergic Receptor Subtypes in Pain and Analgesia Advisors: Robert Elde and George Wilcox

Honors:

1998, Patrick J Manning Research Award
1999, Bacaner Research Award in Basic Medical Science

Thesis Publications:

Stone LS, Vulchanova L, Riedl MS, Wang J, Williams FG, Wilcox GL, Elde R. (1999) Effects of peripheral nerve injury on alpha-2A and alpha-2C adrenergic receptor immunoreactivity in the rat spinal cord. Neuroscience 93:1399-1407.

Stone LS, Broberger C, Vulchanova L, Wilcox GL, Hokfelt T, Riedl MS, Elde R. (1998) Differential distribution of alpha2A and alpha2C adrenergic receptor immunoreactivity in the rat spinal cord. J Neurosci 18:5928-5937.

Stone LS, MacMillan LB, Kitto KF, Limbird LE, Wilcox GL. (1997) The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 17:7157-7165.

Recent Publications:

In press C.J. Goracke-Postle, A.C. Overland, L.S. Stone and C.A. Fairbanks. A polyamine transport system mediates uptake of tritiated agmatine into spinal nerve terminals. 2006      

C.J. Goracke-Postle, H.O. Nguyen, L.S. Stone and C.A. Fairbanks. Release of tritiated agmatine from spinal synaptosomes. Neuroreport 17(23):13-7; 2006.

2004: L.S. Stone and G.L. Wilcox. Alpha-2-Adrenergic and Opioid Receptor Additivity in Rat Locus Coeruleus Neurons. Neuroscience Letters 361(1-3):265-268

2004: L.S. Stone, L. Vulchanova, M.S. Riedl, F.G. Williams, G.L. Wilcox and R. Elde. Effects of Peripheral Nerve Injury on Delta Opioid Receptor (DOR) Immunoreactivity in the Rat Spinal Cord. Neuroscience Letters 361(1-3):208-211

2003: L.S. Stone , Vulchanova L. The pain of antisense: in vivo application of antisense oligonucleotides for functional genomics in pain and analgesia. Adv Drug Deliv Rev. 2003 Aug 28;55(8):1081-112

2003: L.S. Stone, C.A. Fairbanks and G.L. Wilcox. Moxonidine, a Mixed 2-Adrenergic and Imidazoline Receptor Agonist, Identifies a Novel Adrenergic Target for Spinal Analgesia [Review]. Annals of the New York Academy of Sciences 1009:378-385

2003: X-H Guo, C.A. Fairbanks, L.S. Stone and H. Loh. DPDPE-UK14,304 Synergy is Retained in Mu Opioid Receptor Knock-Out Mice. Pain 104:209-217

2003: L.S. Stone and L. Vulchanova. The Pain of Antisense: in vivo Application of Antisense Oligonucleotides for Functional Genomics in Pain and Analgesia [Review]. Advanced Drug Delivery Reviews 55(8):929-1115

2002: C.A. Fairbanks, L.S. Stone, K.F. Kitto, H.O. Nguyen, I.J. Posthumus and G.L. Wilcox. Alpha-2c-Adrenergic Receptors Mediate Spinal Analgesia and Adrenergic-Opioid Synergy. Journal of Pharmacology and Experimental therapeutics 300(1):282-290

2001: L. Vulchanova, T.H. Olsen, L.S. Stone, M.S. Riedl, R. Elde and C.N. Honda. Cytotoxic Targeting of Isolectin Ib4-Binding Sensory Neurons. Neuroscience 108(1):143-155

2001: Guo A, Simone DA, Stone LS , Fairbanks CA, Wang J, Elde R. Developmental shift of vanilloid receptor 1 (VR1) terminals into deeper regions of the superficial dorsal horn: correlation with a shift from TrkA to Ret expression by dorsal root ganglion neurons. Eur J Neurosci. 2001 Jul;14(2):293-304.

2000: C.A. Fairbanks, K.L. Schreiber, K.L. Brewer, C-G. Yu, L.S. Stone, K.F. Kitto, H. O. Nguyen, B.M. Grocholski, D.W. Shoeman, L.J. Kehl, S. Regunathan, D.J. Reis, R.P. Yezierski and G.L. Wilcox. Agmatine Reverses Pain Induced by Inflammation, Neuropathy, and Spinal Cord Injury. Proceedings of the National Academy of Sciences 97:10584-10589

2000: Fairbanks CA , Posthumus IJ, Kitto KF, Stone LS , Wilcox GL. Moxonidine, a selective imidazoline/alpha(2) adrenergic receptor agonist, synergizes with morphine and deltorphin II to inhibit substance P-induced behavior in mice. Pain. 2000 Jan;84(1):13-20.

1998: Vulchanova L, Riedl MS, Shuster SJ, Stone LS , Hargreaves KM, Buell G, Surprenant A, North RA, Elde R. P2X3 is expressed by DRG neurons that terminate in inner lamina II. Eur J Neurosci. 1998 Nov;10(11):3470-8.

1998: Stone LS , Broberger C, Vulchanova L, Wilcox GL, Hokfelt T, Riedl MS, Elde R. Differential distribution of alpha2A and alpha2C adrenergic receptor immunoreactivity in the rat spinal cord. J Neurosci. 1998 Aug 1;18(15):5928-37.

1997: Stone LS , Fairbanks CA , Laughlin TM, Nguyen HO, Bushy TM, Wessendorf MW, Wilcox GL. Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2. Neuroreport. 1997 Sep 29;8(14):3131-5.