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Cheryl Stucky Ph.D. 1995 Thesis Title: Peripheral and Central Mechanisms for Hyperalgesia Advisor: Virginia Seybold

Honors:

John C. Liebeskind Early Career Scholar Award (2001)

Thesis Publications:

Stucky CL, Galeazza MT, Seybold VS. (1993) Time-dependent changes in Bolton-Hunter-labeled 125I-substance P binding in rat spinal cord following unilateral adjuvant-induced peripheral inflammation. Neuroscience 57:397-409.

Stucky CL, Thayer SA, Seybold VS. (1996) Prostaglandin E2 increases the proportion of neonatal rat dorsal root ganglion neurons that respond to bradykinin. Neuroscience 74:1111-1123.

Stucky, C.L., L.G. Abrahams, and V.S. Seybold. (1998) Bradykinin increases the proportion of neonatal rat dorsal root ganglion neurons that responds to capsaicin and protons. Neuroscience 84:1257-1265.

Other Publications:

Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 2007 Jul 12;448(7150):204-8.

Mogil JS, Breese NM, Witty MF, Ritchie J, Rainville ML, Ase A, Abbadi N, Stucky CL, Seguela P. Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli. J Neurosci. 2005 Oct 26;25(43):9893-901.

Breese NM, George AC, Pauers LE, Stucky CL. Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouse. Pain. 2005 May;115(1-2):37-49.

Stucky C.L., Molliver D.C. and Medler K.A. (2004) The P2Y agonist UTP activates cutaneous afferent fibers. Pain, 109: 36-44.

Stucky CL, Medler KA, Molliver DC. The P2Y agonist UTP activates cutaneous afferent fibers. Pain. 2004 May;109(1-2):36-44.

Sluka KA, Price MP, Breese NM, Stucky CL, Wemmie JA, Welsh MJ. Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain. 2003 Dec;106(3):229-39.

Sluka K.A., Price M.P., Breese N.M., Stucky C.L., Wemmie J.A. and Welsh M.J. (2003) Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3 but not ASIC1. Pain, 106: 229-239.

Dirajlal S., Pauers L.E. and Stucky C.L. (2003) Differential response properties of IB4-positive and -negative unmyelinated sensory neurons to protons and capsaicin. J. Neurophys. 89: 513-524.

Dirajlal S, Pauers LE, Stucky CL. Differential response properties of IB(4)-positive and -negative unmyelinated sensory neurons to protons and capsaicin. J Neurophysiol. 2003 Jan;89(1):513-24.

Stucky C.L., Rossi J., Airaksinen M.S. and Lewin G.R. (2002) GFR 2/neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons. J. Physiol. Online, 10.1113/jphysiol.2002.027656.

Stucky C.L., Shin J.B. and Lewin G.R. (2002) Neurotrophin-4: A survival factor for adult sensory neurons. Current Biology 12: 1401-1404.

Zeitz K.P., Guy N., Malmberg A.B., Dirajlal S., Martin W.J., Sun L., Bonhaus D.W., Stucky C.L., Julius D., and Basbaum A.I. (2002) The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J. Neurosci. 22: 1010-1019.

Nogueron MI, Porgilsson B, Schneider WE, Stucky CL, Hillard CJ. Cannabinoid receptor agonists inhibit depolarization-induced calcium influx in cerebellar granule neurons. J Neurochem. 2001 Oct;79(2):371-81.

Stucky CL, Gold MS, Zhang X. Mechanisms of pain. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11845-6.

Price MP, Lewin GR, McIlwrath SL, Cheng C, Xie J, Heppenstall PA, Stucky CL, Mannsfeldt AG, Brennan TJ, Drummond HA, Qiao J, Benson CJ, Tarr DE, Hrstka RF, Yang B, Williamson RA, Welsh MJ. The mammalian sodium channel BNC1 is required for normal touch sensation. Nature. 2000 Oct 26;407(6807):1007-11. Erratum in: Nature 2002 Jul18;418(6895):352.

Pesquero JB, Araujo RC, Heppenstall PA, Stucky CL, Silva JA Jr, Walther T, Oliveira SM, Pesquero JL, Paiva AC, Calixto JB, Lewin GR, Bader M. Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8140-5.

Kinkelin I, Stucky CL, Koltzenburg M. Postnatal loss of Merkel cells, but not of slowly adapting mechanoreceptors in mice lacking the neurotrophin receptor p75. Eur J Neurosci. 1999 Nov;11(11):3963-9.

Stucky CL, Koltzenburg M, Schneider M, Engle MG, Albers KM, Davis BM. Overexpression of nerve growth factor in skin selectively affects the survival and functional properties of nociceptors. J Neurosci. 1999 Oct 1;19(19):8509-16.

Stucky CL, Lewin GR. Isolectin B(4)-positive and -negative nociceptors are functionally distinct. J Neurosci. 1999 Aug 1;19(15):6497-505.

Mannsfeldt AG, Carroll P, Stucky CL, Lewin GR. Stomatin, a MEC-2 like protein, is expressed by mammalian sensory neurons. Mol Cell Neurosci. 1999 Jun;13(6):391-404.

Minichiello L, Casagranda F, Tatche RS, Stucky CL, Postigo A, Lewin GR, Davies AM, Klein R. Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses. Neuron. 1998 Aug;21(2):335-45.

Stucky CL, DeChiara T, Lindsay RM, Yancopoulos GD, Koltzenburg M.Neurotrophin 4 is required for the survival of a subclass of hair follicle receptors. J Neurosci. 1998 Sep 1;18(17):7040-6.

Koltzenburg M, Stucky CL, Lewin GR. Receptive properties of mouse sensory neurons innervating hairy skin. J Neurophysiol. 1997 Oct;78(4):1841-50.

Stucky CL, Koltzenburg M. The low-affinity neurotrophin receptor p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons. J Neurosci. 1997 Jun 1;17(11):4398-405.

Galeazza MT, Stucky CL, Seybold VS. Changes in [125I]hCGRP binding in rat spinal cord in an experimental model of acute, peripheral inflammation. Brain Res. 1992 Sep 25;591(2):198-208. (Part of Thesis)