Our laboratory's major interest is in determining the neural mechanisms responsible for conveying information about painful and itch-producing stimuli from the spinal cord to the brain. In recent years, we have been interested in the mechanisms underlying the relief from itch produced by scratching and how morphine induces itching.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Moser, H.M. and Giesler, G.J. 2013 Analgesia and itch resulting from intrathecal morphine: contrasting effects on different populations of trigeminothalamic tract neurons. J. Neurosci. 33:6093-6101.
Davidson, S., Zhang, Khasabov, S.G., Moser, H.R., Honda, C.N., Simone, D.A., Giesler, G.J., Jr. Pruriceptive spinothalamic tract neurons: Physiological properties and projection targets in the primate. Journal of Neurophysiology 2012 Sep;108(6):1711-23. doi: 10.1152/jn.00206.2012. Epub 2012 Jun 20.
Davidson S, Truong H, Giesler GJ Jr. Quantitative analysis of spinothalamic tract neurons in adult and developing mouse. J Comp Neurol. 2010 Aug 15;518(16):3193-204.
Anderson GR, Cao Y, Davidson S, Truong HV, Pravetoni M, Thomas MJ, Wickman K, Giesler GJ Jr, Martemyanov KA. R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine. Neuropsychopharmacology. 2010 Mar;35(4):1040-50.
Davidson, S., Truong, H., Nakagawa, Y., and Giesler, G.J., Jr. A microinjection technique for targeting regions of embryonic and neonatal mouse brain in vivo. Brain Res. 2010 Jan 11;1307:43-52.
Davidson, S., Truong, H.V. and Giesler, G.J., Jr. 2010 A quantitative analysis of spinothalamic tract neurons in adult and developing mouse. J. Comp. Neurol.518: 3193-3204.
Current Graduate Students:
Hannah Moser (Neuroscience, University of Minnesota).
Former Graduate Students:
Rami Burstein (Ph.D.). Assistant Professor, Dept. of Neurobiology, Harvard University.
Kenneth D. Cliffer (Ph.D.). Staff Scientist, Regeneron Pharmaceuticals, Terrytown, NY.
Steve Davidson (Ph.D. 2009, Neuroscience, University of Minnesota).
Robert Dado (Ph.D. 1992, Neuroscience, University of Minnesota).
James T. Katter (Ph.D. 1993, Neuroscience, University of Minnesota).