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Pankaj Gupta, Ph.D. Associate Professor, Department of Medicine E-mail: gupta013@umn.edu

Research Interests:

My laboratory works on understanding the structural and functional features of heparan sulfate proteoglycans in the context of cytokine and morphogen signaling in various types of stem cells. Current efforts are focused on determining how abnormal heparan sulfates accumulated in mucopolysaccharidosis type I (MPS-I; Hurler syndrome) contribute to neurological abnormalities, and testing if intra-cerebroventricular stem cell transplantation will ameliorate neuropathology and behavioral abnormalities in an immunodeficient mouse model of MPS-I.

Selected Publications:

Garcia-Rivera MF, Colvin-Wanshura LE, Nelson MS, Nan Z, Khan SA, Rogers TB, Maitra I, Low WC, Gupta P . Characterization of an immunodeficient mucopolysaccharidosis type I (MPS-I) mouse model. Brain Res Bull 2007; 74(6): 429-38 .

Gupta P . Impairment of the activity of glycosaminoglycan-binding cytokines by functionally abnormal heparan sulfates: a novel mechanism underlying disease pathophysiology. Scientific World J 2006; 6: 452-56. (DOI 10.1100/tsw.2006.83).

Pan C, Nelson MS, Reyes M, Koodie L, Brazil JJ, Stephenson EJ, Zhao RC, Peters C, Selleck SB, Stringer SE, Gupta P . Functional abnormalities of heparan sulfate in mucopolysaccharidosis-I are associated with defective biological activity of FGF-2 on human multipotent progenitor cells. Blood 2005; 106 (6): 1956-64.

Stringer SE, Nelson MS, Gupta P . Identification of a MIP-1alpha binding heparan sulfate oligosaccharide of defined length that supports long-term in vitro maintenance of human LTC-IC. Blood 2003; 101(6): 2243-45.

Gupta P , Oegema TR, Brazil JJ, Dudek AZ, Slungaard A, Verfaillie CM. Human LTC-IC can be maintained for at least 5 weeks in vitro when interleukin-3 and a single chemokine are combined with O-sulfated heparan sulfates: requirement for optimal binding interactions of heparan sulfate with early-acting cytokines and matrix proteins. Blood 2000; 95: 147-55.

Gupta K, Gupta P (joint first author), Ramakrishnan S, Hebbel RP. Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: effect on human microvascular endothelial cell proliferation and angiogenesis. Angiogenesis 2000; 3: 147-58.