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Research Interests:

Dr. Fatemi's research and clinical interests have focused on the etiology and treatment of schizophrenia and mood disorders. His primary research interests include molecular causes and studies of the biological basis of schizophrenia and autism. He is an attending at the University Hospital and an outpatient adult psychiatrist. Dr. Fatemi has grants supported by March of Dimes, Stanley Medical Research Institute, Jonty Foundation and Kunin Fund of St. Paul Foundation for the investigation and mapping of the developmental genes and proteins in the postmortem brains of patients with schizophrenia, bipolar disorder, major depression and autism. He is also investigating the molecular mechanisms of psychotropic medication effects in rat brain. His latest publications include articles in Molecular Psychiatry, Biological Psychiatry, Journal of Neuroscience and Schizophrenia Research.

Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Fatemi SH, Folsom TD, Reutiman TJ, Sidwell RW. Viral regulation of aquaporin 4, connexin 43, microcephalin and nucleolin. Schizophr Res. 2008 Jan;98(1-3):163-177. Epub 2007 Nov 9.

Fatemi SH, Reutiman TJ, Folsom TD, Sidwell RW. The role of cerebellar genes in pathology of autism and schizophrenia. Cerebellum. 2007 May 16;:1-16 [Epub ahead of print]

Liu L, Schulz SC, Lee S, Reutiman TJ, Fatemi SH. Hippocampal CA1 pyramidal cell size is reduced in bipolar disorder. Cell Mol Neurobiol. 2007 May;27(3):351-8.

Fatemi SH. Olanzapine increases glucogenesis by multiple pathways in brain and muscle. Mol Psychiatry. 2006 Jun;11(6):524-5.

Fatemi SH. Reelin glycoprotein in autism and schizophrenia. Int Rev Neurobiol. 2005;71:179-87.

Fatemi SH, Reutiman TJ, Folsom TD, Bell C, Nos L, Fried P, Pearce DA, Singh S, Siderovski DP, Willard FS, Fukuda M. Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique. Neuropsychopharmacology. 2006 Sep;31(9):1888-99.

Laurence JA, Fatemi SH. Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects. Cerebellum. 2005;4(3):206-10.

Fatemi SH, Stary JM, Hatsukami DK, Murphy SE. A double-blind placebo-controlled cross over trial of bupropion in smoking reduction in schizophrenia. Schizophr Res. 2005 Jul 15;76(2-3):353-6.

Fatemi SH, Pearce DA, Brooks AI, Sidwell RW. Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: a potential animal model for schizophrenia and autism. Synapse. 2005 Aug;57(2):91-9.

Fatemi SH, Snow AV, Stary JM, Araghi-Niknam M, Reutiman TJ, Lee S, Brooks AI, Pearce DA. Reelin signaling is impaired in autism. Biol Psychiatry. 2005 Apr 1;57(7):777-87.

Fatemi SH. Reelin glycoprotein: structure, biology and roles in health and disease. Mol Psychiatry. 2005 Mar;10(3):251-7.

Fatemi SH, Stary JM, Earle JA, Araghi-Niknam M, Eagan E.   GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum. Schizophr Res. 2005 Jan 1;72(2-3):109-22.