Research Interests:
The Georgieff laboratory studies the effects of late fetal and early neonatal iron deficiency on the developing hippocampus and learning and memory behavior in humans and in rodent models. The lab is funded by a grant in its 15th year from NICHD to study this subject at multiple levels including human behavior, human neuroimaging with event related potentials (research in collaboration with Charles Nelson), rodent biochemistry using NMR spectroscopy at 9.4 Tesla, rodent electrophysiology (in collaboration with Michael O'Connor's lab), cell signaling, and rodent behavior (in collaboration with Jonathan Gewirtz). The laboratory has developed two genetic models that interupt iron uptake by the hippocampus at this critical point in development. The hypotheses are that iron deficiency in this developmental time period causes changes in hippocampal CA1 dendritic structure and function that accounts for abnormal recognition memory behavior in iron deficient humans and rodents.
Selected Publications:
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Georgieff MK. Long-term brain and behavioral consequences of early iron deficiency. Nutr Rev. 2011 Nov;69 Suppl 1:S43-8. doi: 10.1111/j.1753-4887.2011.00432.x.
Rao R, Tkac I, Schmidt AT, Georgieff MK. Fetal and neonatal iron deficiency causes volume loss and alters the neurochemical profile of the adult rat hippocampus. Nutr Neurosci. 2011 Mar;14(2):59-65.
Ramel SE, Gray HL, Ode KL, Younge N, Georgieff MK, Demerath EW. Body composition changes in preterm infants following hospital discharge: comparison with term infants. J Pediatr Gastroenterol Nutr. 2011 Sep;53(3):333-8.
Lehmann AE, Ennis K, Georgieff MK, Rao R, Tran PV. Evidence for a hyporesponsive limbic-hypothalamic-pituitary-adrenal axis following early-life repetitive hypoglycemia in adult male rats. Am J Physiol Regul Integr Comp Physiol. 2011 Aug;301(2):R484-90.
Schmidt AT, Ladwig EK, Wobken JD, Grove WM, Georgieff MK. Delayed alternation performance in rats following recovery from early iron deficiency. Physiol Behav. 2010 Nov 2;101(4):503-8.
Tran PV, Georgieff MK, Engeland WC. Sodium depletion increases sympathetic neurite outgrowth and expression of a novel TMEM35 gene-derived protein (TUF1) in the rat adrenal zona glomerulosa. Endocrinology. 2010 Oct;151(10):4852-60.
Brunette KE, Tran PV, Wobken JD, Carlson ES, Georgieff MK . Gestational and Neonatal Iron Deficiency Alters Apical Dendrite Structure of CA1 Pyramidal Neurons in Adult Rat Hippocampus. Dev Neurosci. 2010 Aug;32(3):238-48.
Carlson ES, Fretham SJ, Unger EL, O'Connor MB, Petryk A, Schallert T, Rao R, Tkac I, Georgieff MK. Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems. J Neurodev Disorders, in press, 2010.
Bastian TW, Prohaska JR, Georgieff MK , Anderson GW. Perinatal iron and copper deficiencies alter neonatal rat circulating and brain thyroid hormone levels. Endocrinology, in press, 2010.
Schmidt AT, Ladwig EK, Wobken JD, Grove WM, Georgieff MK . Delayed alternation performance in rats following recovery from early iron deficiency. Physiology and Behavior, in press, 2010
Carlson ES, Tkac I, Magid R, O'Connor MB, Andrews NC, Schallert T, Gunshin H, Georgieff MK , Petryk A. Iron is essential for neuron development and memory function in mouse hippocampus. J Nutrition, Apr;139(4):672-9, 2009.
Riggins T, Miller NC, Bauer PB, Georgieff MK , Nelson CA. Consequences of Low Neonatal Iron Status due to Maternal Diabetes Mellitus on Explicit Memory Performance in Childhood. Developmental Neuropsychology, 34:762-79, 2009.
Current Graduate Students:
Liam Callahan (Neuroscience, University of Minnesota).
Former Graduate Students:
Stephanie Bohmer (Neuroscience, University of Minnesota).
Katya Brunette (Neuroscience, University of Minnesota).
Erik Carlson (Neuroscience, University of Minnesota).
Lyric Jorgenson
(Neuroscience, University of Minnesota). |
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