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Paul A. Iaizzo, Ph.D. Professor of Anesthesiology, Physiology and Surgery Department of Surgery Director of Education for the Lillehei Heart Institute E-mail: iaizz001@umn.edu

Research Interests:

In one of his many projects, his research team has developed, in collaboration with Medtronic, a four chamber working heart model which allows for "real-time" visual assessment of internal anatomy. This collaboration has lead to the creation of the educational CD, the "Visible HeartT Viewer" and the Visible Heart web site.

He also performs applied research in the areas of clinical thermoregulation, skeletal muscle force assessment, the biomechanics of the spine, and the overwintering of black bears (Nature 409:997, 2001). He teaches in numerous courses, such as the year long "New Product Design and Business Development", the intensive week long short courses "Advanced Cardiac Physiology and Anatomy" and "Advanced Physiology of the Neuromuscular Junction",the lecture and lab courses on "Quantitative Physiology", and the UNITE course "Biomedical Applications of Heat transfer in Humans".

Selected Publications:

Sigg DC, Iaizzo PA. In vivo versus in vitro comparison of swine cardiac performance: induction of cardiodepression with halothane. Eur J Pharmacol. 2006 Aug 14;543(1-3):97-107.

Laske TG, Skadsberg ND, Hill AJ, Klein GJ, Iaizzo PA. Excitation of the intrinsic conduction system through his and interventricular septal pacing. Pacing Clin Electrophysiol. 2006 Apr;29(4):397-405.

Xiao YF, TenBroek EM, Wilhelm JJ, Iaizzo PA, Sigg DC. Electrophysiological characterization of murine HL-5 atrial cardiomyocytes. Am J Physiol Cell Physiol. 2006 Sep;291(3):C407-16.

Hill AJ, Laske TG, Coles JA Jr, Sigg DC, Skadsberg ND, Vincent SA, Soule CL, Gallager WJ, Iaizzo PA : In vitro studies of human hearts. The Annals of Thoracic Surgery 79: 168-177, 2005.

Coles JA Jr, Sigg, D, Iaizzo PA : Role of kappa-opioid receptor activation in pharmacological preconditioning in swine. American Journal of Physiology: Heart and Circulatory 284:2091-2099, 2003.

Hilse MA, Erdman AG, Iaizzo PA : Axial unloading therapy device for cervical spine rehabilitation. Journal of Medical Engineering & Technology 27: 207-217, 2003.

Hill A, Coles JA Jr, Sigg DC , Laske, TG, Iaizzo PA : Images of the human coronary sinus ostium obtained from isolated working hearts. The Annals of Thoracic Surgery 76: 2108, 2003.