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Jose V. Pardo, M.D., Ph.D. Associate Professor, Department of Psychiatry E-mail: jvpardo@james.psych.umn.edu Lab Website

Research Interests:

• Cognitive neuroscience of higher cognitive functions and mental disorders
• Neuroimaging of brain physiology
• Application of high performance computing to biomedicine
• Application of brain imaging to psychiatry and neurosurgery

Dr. Pardo leads a research program which seeks to elucidate the functional architecture of the human brain with particular emphasis on how dysfunction within neural networks relates to psychiatric disorders. The multidisciplinary approach (in close collaboration with the Brain Sciences Center, Department of Psychology, Department of Psychiatry, and GRECC) involves methods from cognitive neuroscience, including several imaging modalities, particularly fMRI and PET. Brain systems under study in normal subjects include attention and its involvement in memory and affect; language processing and applications to preoperative neurosurgical assessment; and emotional processing through mood induction by cognitive and sensory stimuli. Clinical protocols currently underway seek to relate pathophysiology to the evolving neuroanatomy of the mind. Patient populations include those with mood disorders, schizophrenia, and post traumatic stress disorder.

Selected Publications:

Georgopoulos AP, Karageorgiou E, Leuthold AC, Lewis SM, Lynch JK, Alonso AA, Aslam Z, Carpenter AF, Georgopoulos A, Hemmy LS, Koutlas IG, Langheim FJ, McCarten JR, McPherson SE, Pardo JV, Pardo PJ, Parry GJ, Rottunda SJ, Segal BM, Sponheim SR, Stanwyck JJ, Stephane M, Westermeyer JJ. Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders. J Neural Eng. 2007 Dec;4(4):349-355. Epub 2007 Aug 27.

Munch KR, Carlis JV, Pardo JV, Lee JT. Bringing functional brain image analysis to the clinician: Initial assessment of an online interactive diagnostic aide. Comput Biol Med. 2007 Nov 15; [Epub ahead of print]

Pardo JV, Sheikh SA, Kuskowski MA, Surerus-Johnson C, Hagen MC, Lee JT, Rittberg BR, Adson DE. Weight loss during chronic, cervical vagus nerve stimulation in depressed patients with obesity: an observation. Int J Obes (Lond). 2007 Nov;31(11):1756-9. Epub 2007 Jun 12.

Pardo JV, Lee JT, Sheikh SA, Surerus-Johnson C, Shah H, Munch KR, Carlis JV, Lewis SM, Kuskowski MA, Dysken MW. Where the brain grows old: decline in anterior cingulate and medial prefrontal function with normal aging. Neuroimage. 2007 Apr 15;35(3):1231-7. Epub 2007 Jan 25.

Stephane M, Hagen MC, Lee JT, Uecker J, Pardo PJ, Kuskowski MA, Pardo JV. About the mechanisms of auditory verbal hallucinations: a positron emission tomographic study. J Psychiatry Neurosci. 2006 Nov;31(6):396-405.

Faris PL, Eckert ED, Kim SW, Meller WH, Pardo JV, Goodale RL, Hartman BK. Evidence for a vagal pathophysiology for bulimia nervosa and the accompanying depressive symptoms. J Affect Disord. 2006 May;92(1):79-90.

Pardo JV, Pardo PJ, Humes SW, I Posner M. Neurocognitive dysfunction in antidepressant-free, non-elderly patients with unipolar depression: alerting and covert orienting of visuospatial attention. J Affect Disord. 2006 May;92(1):71-8.

Kilpatrick LA, Zald DH, Pardo JV, Cahill LF. Sex-related differences in amygdala functional connectivity during resting conditions. Neuroimage. 2006 Apr 1;30(2):452-61.

Former Graduate Students:

Matthew Hagen (Ph.D. 2004, Neuroscience, University of Minnesota).

Jennifer Nagode (Ph.D. 2002, Neuroscience, University of Minnesota).