|
Donald A. Simone, Ph.D.
Professor,
Departmnet of Diagnostic and Biological Sciences
E-mail: simon003@umn.edu |
Research Interests:
The general focus of our research is the study of anatomical,
physiological, and pharmacological mechanisms underlying pain sensation.
Primary research interests include neural encoding of cutaneous
and muscle pain. We are interested particularly in the neural mechanisms
that account for hyperalgesia (enhanced sensitivity to pain) following
tissue injury or disease, and the modulation of excitability of
sensory neurons involved in pain transmission. Psychophysical, behavioral,
and electrophysiological techniques are used in parallel studies
using animals and humans.
Selected Publications:
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Khasabov SG, Hamamoto DT, Harding-Rose C, Simone DA. Tumor-evoked hyperalgesia and sensitization of nociceptive dorsal horn neurons in a murine model of cancer pain.
Brain Res. 2007 Nov 14;1180:7-19.
Khasabova IA, Stucky CL, Harding-Rose C, Eikmeier L, Beitz AJ, Coicou LG, Hanson AE, Simone DA, Seybold VS. Chemical interactions between fibrosarcoma cancer cells and sensory neurons contribute to cancer pain. J Neurosci. 2007 Sep 19;27(38):10289-98.
Davidson S, Zhang X, Yoon CH, Khasabov SG, Simone DA, Giesler GJ Jr. The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J Neurosci. 2007 Sep 12;27(37):10007-14.
Hamamoto DT, Giridharagopalan S, Simone DA. Acute and chronic administration of the cannabinoid receptor agonist CP 55,940 attenuates tumor-evoked hyperalgesia. Eur J Pharmacol. 2007 Mar 8;558(1-3):73-87.
Budai D, Khasabov SG, Mantyh PW, Simone DA. NK-1 receptors modulate the excitability of ON cells in the rostral ventromedial medulla. J Neurophysiol. 2007 Feb;97(2):1388-95.
Gilchrist LS, Cain DM, Harding-Rose C, Kov AN, Wendelschafer-Crabb G, Kennedy WR, Simone DA. Re-organization of P2X3 receptor localization on epidermal nerve fibers in a murine model of cancer pain. Brain Res. 2005 May 24;1044(2):197-205.
Khasabov SG, Ghilardi JR, Mantyh PW, Simone DA. Spinal neurons that express NK-1 receptors modulate descending controls that project through the dorsolateral funiculus. J Neurophysiol. 2005 Feb;93(2):998-1006.
Johanek LM, Simone DA. Cannabinoid agonist, CP 55,940, prevents capsaicin-induced sensitization of spinal cord dorsal horn neurons. J Neurophysiol. 2005 Feb;93(2):989-97.
Wacnik PW, Eikmeier LJ, Simone DA, Wilcox GL, Beitz AJ. Nociceptive characteristics of tumor necrosis factor-alpha in naive and tumor-bearing mice. Neuroscience. 2005;132(2):479-91.
Current Graduate Students:
Carl Potenzieri (Neuroscience, University of Minnesota).
Former Graduate Students:
Lisa Johanek (Ph.D. 2004,
Neuroscience, University of Minnesota). |
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