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Current Position:
- Faculty in Biology at
Minneapolis Community and Technical College
Undergraduate Institution and Major/Degree:
Major Advisor(s):
Research Description:
Inhibition of the HPA axis is traditionally thought to occur through glucocorticoid negative feedback; however, under conditions of chronic food or water restriction, rapid inhibition of plasma corticosterone occurs following restriction-induced feeding or drinking. Rapid inhibition if the HPA axis is thought to occur through neural pathways independent of glucocorticoid negative feedback. Furthermore, rapid inhibition of the HPA axis can be classically conditioned. These data suggest that repeated alleviation from stress recruits inhibitory afferents that are not active during inhibition of the HPA axis following acute stress. The focus of my research is to examine the hypothesis that repeated inhibition of the HPA axis in a water restriction model recruits multi-synaptic efferents that contribute to inhibition of the PVN. Moreover, additional experiments are proposed to demonstrate that inhibition of hippocampal efferents prevents the conditioned fall in corticosterone.
Lab Rotations:
- Michael Georgieff
- Bill Engeland
- Moses Njenga
Courses Taken Beyond the Core Courses:
- GRAD 8101 Preparing Future Faculty (Teaching in Higher Education)
- PHCL 8208 Neuropsychopharmacology
- PHSL 5101 Human Physiology
- PSY 8026 Neuro-Immune Interactions
- PHSL 8216 Selected Topics in Autonomic and Neuroendocrine Regulation (journal club)
Conferences Attended and Presentations:
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American Physiological Society Conference "Neurohypophyseal Hormones: From Genomics and Physiology to Disease" Steamboat Springs CO, July 2005
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The Endocrine Society "The Neuroendocrinology of Stress" San Diego CA, June 2005
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Society for Neuroscience, San Diego CA, November 2001, Orlando FL, November 2002, San Diego CA, October 2004
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Society for Menstrual Cycle Research, Chicago IL, May 1997
Committee Members:
- Chris Honda- chair
- Allen Levine
- Paul Mermelstein
- John Osborn
- Bill Engeland- advisor
Selected Publications and Presentations:
Thesis Publications:
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Arnhold M.M., Yoder J.M., Engeland Subdiaphragmatic vagotomy prevents reduction in plasma corticosterone when water-restricted rats drink - a potential role for the vagus in stress relief. Submitted : Endocrinology.
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Arnhold M.M., Engeland WC. 2007 Differential regulation of parvocellular activity in the paraventricular nucleus of the hypothalamus following a single or repeated episode of dehydration induced drinking. Experimental Neurology 206(1):126-36.
- Wotus C, Arnhold M.M., Engeland WC. 2007 Dehydration-induced drinking results in rapid decreases in cFos expression in hypothalamic paraventricular neurons expressing vasopressin, but not corticotropin-releasing hormone. Am J Physiol Regul Integr Comp. Physiol 292(3):R1349-58.
- Ulrich_Lai, Y.M., Arnhold, M.M., and Engeland, W.C. 2006 Adrenal splanchnic innervation contributes to the diurnal rhythm of plasma corticosterone in rats by modulating adrenal sensitivity to ACTH. Am J Physiol Regul Integr Comp. Physiol 290(4):R1128-35.
- Engeland, W.C. and Arnhold, M.M. 2005 Neural circuitry in the regulation of adrenal corticosterone rhythmicity. Endocrine. 28(3):325-32.
Publications:
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Arnhold M.M., Engeland WC. Differential regulation of parvocellular activity in the paraventricular nucleus of the hypothalamus following a single or repeated episode of dehydration induced drinking. Submitted: Experimental Neurology.
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Wotus C, Arnhold MM, Engeland WC. Dehydration-induced drinking results in a rapid decrease in fos expression in hypothalamic parventricular neurons expressing vasopressin, but not corticotropin-releasing hormone. Am J Physiol Regul Integr Comp Physiol. 2006 Oct 26
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Ulrich-Lai YM, Arnhold MM, Engeland WC. Adrenal splanchnic innervation contributes to the diurnal rhythm of plasma corticosterone in rats by modulating adrenal sensitivity to ACTH. Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R1128-35.
- Engeland, W.C. and Arnhold, M.M., Neural circuitry in the regulation of adrenal corticosterone rhythmicity. Endocrine. (2005) Dec;28(3):325-32.
Talks:
- Graduate Program in Neuroscience Colloquium series, University of Minnesota, March 2005 M.M. Arnhold. Neural mechanisms mediating rapid inhibition of the hypothalamic-pituitary-adrenal axis in water-restricted rats.
Poster Presentations:
- American Association of University Women meeting, Grand Rapids MN, October 2006 M. M. Arnhold. The Neurobiology of Stress: The Good, The Bad, and The Ugly.
- The Endocrine Society "The Neuroendocrinology of Stress" San Diego, CA, June 2005 M.M. Arnhold, E.J. Melief, W.C. Engeland. Diurnal variation in splanchnic neural modulation of non-stress plasma corticosterone revealed by repeated blood sampling in rats.
- American Physiological Society Conference "Neurohypophyseal Hormones: From Genomics and Physiology to Disease" Steamboat Springs, CO, July 2005
- M.M. Arnhold, J.L. Armstrong, W.C. Engeland. Differential regulation of parvocellular activity in the paraventricular nucleus of the hypothalamus following a single or repeated episode of dehydration-induced drinking.
- 34th Annual Society for Neuroscience (SFN) Conference, San Diego, CA, October 2004 M.M. Arnhold, C. Wotus, W.C. Engeland. Dehydration-induced drinking results in a rapid decrease in Fos in hypothalamic paraventricular neurons expressing vasopressin, but not corticotropin-releasing hormone.
- 8th Annual Graduate Program in Neuroscience Retreat, University of Minnesota, February 2004 M.M. Arnhold, W.C. Engeland. Rapid inhibition of the HPA axis in response to water deprivation induced drinking.
- 32nd Annual Society for Neuroscience (SFN) Conference, Orlando, FL, November 2002 M.M. Arnhold, M. Pravetoni, S.B. Sparber, L.M. Schrott. Prenatal Opiate withdrawal increases interleukin-1 and inducible nitric oxide synthase mRNA in Embryonic Chicken Cerebral Hemispheres
- Society for Menstrual Cycle Research, Chicago IL, 1997 M.M. Arnhold, K. Erdal, Investigation of Cognitive Fluctuation Across the Menstrual Cycle
Awards and Honors:
- Ruth L. Kirschstein National Research Service Award, 2001-2002
- Pharmaconeuroimmunology Training Fellowship, University of Minnesota, 2004-present
- Stark Fellowship, Graduate Program in Neuroscience, University of Minnesota, 2005
Professional Memberships:
- Society for Neuroscience, 2004- present
- American Physiological Society, 2004-present
- Endocrine Society, 2004-present
- Women in Endocrinology, 2005-present
- American Neuroendocrine Society, 2005-present
- Graduate Women in Science 2005-present
Home Town:
Non-Neuroscience interests:
- Dance (Mitch taught jazz and modern dance and spent time performing in her 5 years between undergrad and starting grad school)
- Yoga/Pilates
- Outdoorsy things: hiking, camping, etc.
- TRAVELING!!!
- Cooking
- Gardening
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