|
|
 |
 |
Holly Kordasiewicz
Ph.D. 2006 |
Undergraduate Institution and Major/Degree:
- State University of New York at Geneseo
Major Advisor(s):
Research Description:
My current research focuses on voltage-dependent calcium channels (VDCCs) and their role in the pathogenesis of spinocerebellar ataxia type six (SCA6). SCA6 is a dominantly inherited progressive ataxia, which leads to marked cerebellar atrophy and specifically Purkinje cell degeneration. SCA6 is caused by a mutation in the CACNA1A gene, which encodes the pore forming subunit (a1A) of the P/Q-type voltage gated calcium channel. We are currently exploring how the SCA6 mutation alters normal functioning of the a1A subunit and how this mutation can cause cell death as observed in SCA6.
Lab Rotations:
- Christopher Gomez
- Paul Mermelstein
- Stanley Thayer
Courses Taken Beyond the Core Courses:
- GCD 8213 Topics in Molecular Biology
- GCD 8151 Advanced Cell Biology
- BIOC 4332 Signal Transduction/Gene Expression
- BIOC 4331 Structure/Catalyst/Metabolism
Graduate Level Minor:
Conferences Attended and Presentations:
- Society for Neuroscience Annual Meeting - Fall 1999, 2000, 2001, 2002,
2004
- Annual Cell Biology Meeting - Fall 2003
Committee Members:
- Paul Mermelstein - Chair
- Harry Orr
- Paul Letourneau
- Christopher Gomez - Advisor
Selected Publications and Presentations:
Publications:
- Boulware MI, Kordasiewicz H, Mermelstein PG. Caveolin proteins are essential for distinct effects of membrane estrogen receptors in neurons. J Neurosci. 2007 Sep 12;27(37):9941-50.
- Raike RS, Kordasiewicz HB , Thompson RM, Gomez CM. Dominant-negative suppression of Cav2.1 currents by alpha(1)2.1 truncations requires the conserved interaction domain for beta subunits. Mol Cell Neurosci. 2007 Feb;34(2):168-77.
- Kordasiewicz HB , Thompson RM, Clark HB, Gomez CM. C-termini of P/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity. Hum Mol Genet. 2006 May 15;15(10):1587-99.
Conference Presentations:
-
Kordasiewicz HB, Thompson RM, Gomez CM. Nuclearly translocated Q1A C-termini bearing an SCA6 expansion are cytotoxic. Society for Neuroscience, 2004.
-
Kordasiewicz HB, Thompson RM, Raike RS, Gomez CM. C-terminal cleavage and nuclear translocation of the Q1A CaV2.1 calcium channel subunit. American Society for Cell Biology, 2003.
-
Raike RS, Kordasiewicz HB, Schott K, Thompson RM, Charnet P, Gomez CM. Function and Expression of a Novel Episodic Ataxia Type 2 Mutation. Society for Neuroscience, 2002
-
Bauter MR, Virgolini MB, Weston DD, Brownrigg HB, Cory-Slechta DA.
Significance of the ventral subiculum-preforntal cortex circuit in modulation of fixed interval schedule controlled behavior. Society for Neuroscience, 2002.
-
Bazzett T, Brownrigg HB, Shavit Y, Hasson U. Integration of a CD-ROM Virtual Laboratory into Neuroscience Course Work. Society for Neuroscience, 2000.
-
Bazzett T, Sharpe M, Brownrigg HB and Bauter M. Assessment of Motor and Cognitive Deficits in Rats: Construction and Use of an Operant chamber. Society for Neuroscience, 1999.
Home Town:
|
|
