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C. Dirk Keene Ph.D. 2003 Thesis Title: Experimental Huntington's Disease - Neuroprotective Effects of Tauroursodeoxycholic Acid and 1H NMR Spectroscopic Characterization Advisor: Walter Low

Publications:

Tkac I, Dubinsky JM, Keene CD , Gruetter R, Low WC. Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy. J Neurochem. 2007 Mar;100(5):1397-406. Epub 2007 Jan 8.

Burns TC, Ortiz-Gonzalez XR, Gutierrez-Perez M, Keene CD , Sharda R, Demorest ZL, Jiang Y, Nelson-Holte M, Soriano M, Nakagawa Y, Luquin MR, Garcia-Verdugo JM, Prosper F, Low WC, Verfaillie CM. Thymidine analogs are transferred from prelabeled donor to host cells in the central nervous system after transplantation: a word of caution. Stem Cells. 2006 Apr;24(4):1121-7. Epub 2005 Dec 22.

Ortiz-Gonzalez XR, Keene CD , Verfaillie CM, Low WC. Neural induction of adult bone marrow and umbilical cord stem cells. Curr Neurovasc Res. 2004 Jul;1(3):207-13.

Brustovetsky N, LaFrance R, Purl KJ, Brustovetsky T, Keene CD , Low WC, Dubinsky JM. Age-dependent changes in the calcium sensitivity of striatal mitochondria in mouse models of Huntington's Disease. J Neurochem. 2005 Jun;93(6):1361-70.

Tkac I, Henry PG, Andersen P, Keene CD , Low WC, Gruetter R. Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T. Magn Reson Med. 2004 Sep;52(3):478-84.

Keene, CD, XR Ortiz-Gonzalez, YH Jiang, D Largaespada, CM Verfaillie, and WC Low, Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos, Cell Transplantation 12:201-214 (2003).

Zhao, LR, WM Duan, M Reyes, CD Keene, CM Vervaillie, and WC Low, Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats, Experimental Neurology, 174(1):11-20 (2002).

Jiang, YH, BN Jahagirdar, RL Reinhardt, RE Schwartz, CD Keene, X. Ortiz-Gonzalez, M Reyes, T Lenvik, T Lund, M Blackstad, JB Du, S Aldrich, A Lisberg, WC Low, DA Largaespada, CM Verfaillie, Pluripotent nature of adult marrow derived mesenchymal stem cells, Nature 418:41-49 (2002).

Keene, CD, CMP Rodrigues, T Eich, MS Chhabra, CJ Steer, and WC Low, Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease, Proceedings of the National Academy of Science 99:10671-10676 (2002).

Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD , Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002 Jul 4;418(6893):41-9. Epub 2002 Jun 20.

Tkac I, Keene CD , Pfeuffer J, Low WC, Gruetter R. Metabolic changes in quinolinic acid-lesioned rat striatum detected non-invasively by in vivo (1)H NMR spectroscopy. J Neurosci Res. 2001 Dec 1;66(5):891-8.

Keene CD , Rodrigues CM, Eich T, Linehan-Stieers C, Abt A, Kren BT, Steer CJ, Low WC. A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease. Exp Neurol. 2001 Oct;171(2):351-60.