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Undergraduate Institution and Major/Degree:
- Minnesota State University Moorhead, BA, Biology and
Chemistry, Emphasis in Biotechnology, 2004
Major Advisor(s):
Research Description:
My research interest focuses on the mechanisms behind neurovascular coupling – the process by which cerebral blood flow is spatially and temporally directed to provide increased nutrients and oxygen to sites of high neuronal activity. Although functional hyperemia is widely used to measure brain activity in clinical and research settings by imaging techniques such as fMRI, the fundamental cellular mechanisms underlying it are not well understood. Recent evidence has shown that glial cells mediate neurovascular coupling in the brain and our lab has demonstrated in the whole mount preparation of the rat retina, that light and glial stimulation can evoke both vasodilations and vasoconstrictions. The generation of bi-directional vasomotor activity raises the question of how such responses are controlled. I am currently investigating the role of small signaling molecules such as nitric oxide (NO) and oxygen (O 2 ) in modulating vascular responses in retinas following light- and glial-stimulation.
Committee Members:
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Eric A. Newman
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Paulo Kofuji (chair)
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Esam E. El-Fakahany
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Cheryl Olman
Lab Rotations:
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Paul Mermelstein
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Karen Ashe
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Eric Newman
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Karen Mesce
Courses Taken Beyond the Core Courses:
- PUBH 6450 Biostatistics I
- PUBH 6451 - Biostatistics II
- PHYS 5201 Computational Neuroscience I
- CMB 8361 Neuro-Immune Interactions
Graduate Level Minor:
- Statistical and Computational Analysis
Conferences Attended and Presentations:
- Society for Neuroscience - Fall 2005, 2006
- Americal Society for Biochemistry and Molecular Biology - 2004
- Minnesota Academy of Sciences - 2003, 2004
- Midwest Regional Developmental Biology Meeting and
Singer Symposium - 2004
Publications:
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Sorra KE, Mishra A, Kirov SA, Harris KM. Dense core vesicles resemble active-zone transport vesicles and are diminished following synaptogenesis in mature hippocampal slices. Neuroscience 2006 Sep 15;141(4):2097-106.
Presentations:
- Mishra A , Hu M, Newman EA. Oxygen modulates neurovascular coupling in the rat retina. Society for Neuroscience Annual Meeting: 2007, San Diego , CA.
- Mishra A, Sorra KE, Kirov SA, Harris KM. Dense Core Vesicles as a Substrate for Synaptogenesis in the Hippocampus. Society for Neuroscience Annual Meeting: 2005, Washington , DC .
- Mishra A , Ronderos D, Provost JJ, Wallert MA. Phenylephrine activates Na + -H + exchangers via bifurcating pathways involving different PKC isoforms. American Society for Biochemistry and Molecular Biology: 2004, Boston , MA.
- Mishra A , Hamann B, Brisch E, Wisenden BD. Development and behavioral ontogeny of antipredator behavior in cichlid larvae. Minnesota Academy of Science: 2003, St. Paul , MN.
Teaching Experience:
- Teaching Assistant, Introduction to Neuroscience II: Biological Basis of Behavior, University of Minnesota , MN - Spring, 2007
Awards and Honors:
- 3M fellowship (2005-2009)
- Stark Award (2008)
Professional Memberships:
Home Town:
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