My research involves the use of animal models to study the behavioral pharmacology of addiction to nicotine and other drugs of abuse. The long-term goal of this work is to inform the development of more effective preventions and treatments for drug addiction. Specific areas of interest include: a) Development of models involving tobacco product exposure to inform FDA regulation of tobacco products and to understand the role of non-nicotine constituents in tobacco addiction; b) Role of negative affective (emotional) withdrawal symptoms and other factors in individual differences in vulnerability to drug addiction; c) Development of novel pharmacotherapies for addiction including the neuropeptide oxytocin and immunotherapy (vaccines and monoclonal antibodies). I use a number of behavioral models to address these areas including intracranial self-stimulation, intravenous drug self-administration, drug discrimination, place / taste conditioning, and locomotor sensitization.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Schmidt, C.E., Manbeck, K.E., Shelley, D., Harris, A.C. (2015). Blockade of cholinergic transmission elicits somatic signs in nicotine-naïve adolescent rats. Frontiers in Pharmacology. 6:239.
Muelken, P., Schmidt, C.E., Shelley, D., Tally, L. Harris, A.C. (2015). A two-day continuous nicotine infusion is sufficient to demonstrate nicotine withdrawal in rats as measured using intracranial self-stimulation. PLOS One. 10(12):e0144553.
Harris, A.C., Mattson, C., Shelley, D. and LeSage, M.G (2014). Restraint stress attenuates nicotine's locomotor stimulant but not discriminative stimulus effects in rats. Pharmacology, Biochemistry, and Behavior, 124, 92-100.
Harris, A.C., Tally, L., Schmidt C.E., Muelken, P., Stepanov, I., Saha, S., Isaksson Vogel, R., LeSage, MG. (2015). Animal models to assess the abuse liability of tobacco products: Effects of smokeless tobacco extracts on intracranial self- stimulation. Drug and Alcohol Dependence. 147, 60-67.
Holtz, N.A., Radke, A.K., Zlebnik, N.E., Harris, A.C., Carroll, M.E. (2015). Intracranial self-stimulation reward thresholds during morphine withdrawal in rats bred for High (HiS) and low (LoS) saccharin intake. Brain Research. 1602, 119-126.
Harris, A.C., Tally, L., Muelken, P., Banal, A., Schmidt, C.E., Cao, Q., LeSage, M.G. (2015). Effects of nicotine and minor tobacco alkaloids on intracranial self - stimulation in rats. Drug and Alcohol Dependence, 153, 330-334..
Harris, A.C., LeSage, M.G., Shelley, D., Perry, J.L., Pentel, P.R., Owens, S.M,. (2015). The anti-(+)- methamphetamine monoclonal antibody mAb7F9 attenuates acute (+)- methamphetamine effects on intracranial self-stimulation in rats. PLOS One. 10(3): e0118787. doi:10.1371/journal.pone.0118787
Manbeck, K.E., Shelley, D., Schmidt, C.E., and Harris, A.C. (2014). Effects of oxytocin on nicotine withdrawal in rats. Pharmacology, Biochemistry, and Behavior, 116, 84-89.
Raleigh, M.D., Pravetoni, M., Harris, A.C., Birnbam, A.K., and Pentel, P.R. (2013). Selective effects of a morphine conjugate vaccine on heroin and metabolite distribution and heroin-induced behaviors in rats. Journal of Pharmacology and Experimental Therapeutics, 344, 397-406.
Hamilton, K.L., Harris, A.C., & Gewirtz, J.C. (2013). Affective and neuroendocrine effects of withdrawal from chronic, long-acting opiate administration. Brain Research, 1538, 73-82.
Harris, A.C.* Manbeck, K.E., Schmidt, C.E., and Shelley, D. (2013). Mecamylamine elicits withdrawal-like signs in rats following a single dose of nicotine. Psychopharmacology, 225, 291-302