David R. Brown, Ph.D.

Professor, Department of Veterinary and Biomedical Sciences

E-MAIL: brown013@umn.edu

Research Interests:

Dr. Brown's laboratory investigates the functional consequences of neuronal communication with epithelial and immune cells in mucosal tissues, particularly those found in the intestine, female reproductive tract and airways. His studies demonstrate that drugs of abuse, which alter peripheral neurotransmission at these sites, can affect protective mechanisms and microbial colonization at mucosal surfaces. Studies are conducted primarily at the molecular, cellular, and tissue levels using an array of cutting-edge methodological approaches. The results of these investigations provide important insights into drug targets for the alleviation of infection, inflammation and pain as well as enhancements in vaccine efficacy and drug delivery.

Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Brosnahan AJ, Jones BJ, Dvorak CM, Brown D.R. Morphine attenuates apically-directed cytokine secretion from intestinal epithelial cells in response to enteric pathogens. Pathogens. 2014 Apr 2;3(2):249-57.

Brosnahan AJ, Vulchanova L, Witta SR, Dai Y, Jones BJ, Brown D.R. Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells. J Neuroimmunol. 2013 Jun 15;259(1-2):8-16.

Brosnahan, A.J. and Brown, D.R.: Porcine IPEC-J2 intestinal epithelial cells in microbiological investigations. Vet. Microbiol., 2012 May 4;156(3-4):229-37.

Lyte, M., L. Vulchanova and Brown, D.R.: Stress at the intestinal surface:
catecholamines and mucosa-bacteria interactions. Cell Tiss. Res., 343:23-32,

Keegan MT, Gali B, Brown D.R., Harrison BA, Plevak DJ, Findlay JY. Serum vasopressin concentrations during orthotopic liver transplantation. Transplant Proc. 2010 Sep;42(7):2594-8.

Green, B.T. and Brown, D.R.: Interactions between bacteria and the gut
mucosa: do enteric neurotransmitters acting on the mucosal epithelium influence intestinal colonization or infection? In: Microbial Endocrinology, M. Lyte and P. Freestone, eds., chapter 5, Springer, Berlin, pp. 89-109, 2010

Brown, D.R. and L.D. Price: Catecholamines and sympathomimetic drugs decrease early Salmonella Typhimurium uptake into Peyer’s patches of porcine jejunum. FEMS Immunol. Med. Microbiol., 52:29-35, 2008

Brown, D.R. and S.M. O’Grady: The Ussing chamber and measurement of drug actions on mucosal ion transport. In: Current Protocols in Pharmacology, John Wiley, N.Y., 41:7.12.1-7.12.17, 2008.

Schmidt, L.D., Y.H. Xie, L. Vulchanova, M. Lyte and Brown, D.R.: Autonomic neurotransmitters modulate immunoglobulin A secretion in porcine colonic mucosa. J. Neuroimmunol., 185: 20-28, 2007.

Vulchanova, L., M.A. Casey, G.W. Crabb, W. R. Kennedy and Brown, D.R.: Anatomical evidence for enteric neuro-immune interactions in Peyer’s patches. J. Neuroimmunol., 185: 64-74, 2007.

Schreiber, K.L., L.D. Price and Brown, D.R.: Evidence for neuromodulation of enteropathogen invasion in the intestinal mucosa. J. Neuroimmune Pharmacol., 2:329-337, 2007.

Schmidt, L.D., L.J. Kohrt and Brown, D.R.: Comparison of growth phase on Salmonella enterica serovar Typhimurium invasion in an epithelial cell line (IPEC J2) and mucosal explants from porcine small intestine. Comparat. Immunol. Microbiol. Infect. Dis., 31:63-69, 2008.

Former Graduate Students:

Kristin Schreiber (Ph.D. 2004, Neuroscience, University of Minnesota).

David Brown