Hubert Lim , Ph.D.

Assistant Professor, Department of Biomedical Engineering


Research Interests:

The goal of my lab is to push the development and translation of brain-machine interfaces from scientific concept into clinical application with close collaboration with clinicians and industry.  Brain-machine interfaces span a broad array of applications and consist of either direct connection of a device to neurons within the brain or neural communication through noninvasive techniques, such as EEG recordings and transcranial magnetic stimulation.  The initial focus of my lab is to develop and improve implantable neural prostheses for restoring auditory function in deaf or hearing-impaired patients as well as those experiencing severe tinnitus (i.e., a phantom auditory percept that persists without any actual sound input).  There are several auditory implants currently used in humans.  This includes the cochlear implant (stimulates auditory nerve fibers), the auditory brainstem implant (stimulates the cochlear nucleus), and the auditory midbrain implant (stimulates the inferior colliculus), which my colleagues and I recently developed and translated into a clinical device.  Some of these implants, as well as a few recent cortical devices, have also been used to suppress tinnitus.  Although the outcomes have been encouraging, there are still many limitations with these devices, such as poor hearing in noisy environments and substantial variability in performance across patients.  One fundamental limitation in improving these devices has been the lack of understanding of how the central auditory system in humans processes and represents sound information.

My lab employs various experimental and engineering techniques in animals (e.g., guinea pig, cat) and humans to understand the human brain and how to successfully implement a neural device.  This includes acute and chronic implantation of electrode arrays into the animal brain to investigate how the auditory system codes for different sound features as well as the effects of electrical activation of multiple auditory and nonauditory pathways on sound coding and perception.  Various electrophysiological and modeling techniques are also used to investigate the descending and plasticity circuitry of the auditory system, which is important for understanding how to improve and optimize stimulation strategies for restoring hearing as well as suppressing tinnitus.  By performing EEG and psychophysical studies in humans in response to acoustic and electrical stimulation and linking these results to those obtained in animals, we then obtain a better understanding of sound processing within the human brain that can guide the development of the next generation of auditory implants.

Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Lim HH, Lenarz T. Auditory Midbrain Implant: Research and development towards a second clinical trial. Hearing Research 322: 212-223, 2015.

Berding G, Wilke F, Rode T, Haense C, Joseph G, Meyer GJ, Mamach M, Lenarz M, Geworski L, Bengel FM, Lenarz T, Lim HH. Positron Emission Tomography Imaging Reveals Auditory and Frontal Cortical Regions Involved with Speech Perception and Loudness Adaptation. PLoS One. 2015 Jun 5;10(6):e0128743.

Straka MM, Hughes R, Lee P, Lim HH. Descending and tonotopic projection patterns from the auditory cortex to the inferior colliculus. Neuroscience. 2015 Aug 6;300:325-37.

Czanner G, Sarma SV, Ba D, Eden UT, Wu W, Eskandar E, Lim HH, Temereanca S, Suzuki WA, Brown EN. Measuring the signal-to-noise ratio of a neuron. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7141-6.

Markovitz CD, Smith BT, Gloeckner CD, Lim HH. Investigating a new neuromodulation treatment for brain disorders using synchronized activation of multimodal pathways. Sci Rep. 2015 Mar 25;5:9462.

Markovitz CD, Hogan PS, Wesen KA, Lim HH. Pairing broadband noise with cortical stimulation induces extensive suppression of ascending sensory activity. J Neural Eng. 2015 Apr;12(2):026006.

Lim HH, Lenarz T. Auditory midbrain implant: research and development towards a second clinical trial. Hear Res. 2015 Apr;322:212-23.

Lim HH, Shannon RV. Two Laskers and Counting: Learning From the Past Enables Future Innovations With Central Neural Prostheses. Brain Stimul. 2015 May-Jun;8(3):439-41.

Offutt SJ, Ryan KJ, Konop AE, Lim HH. Suppression and facilitation of auditory neurons through coordinated acoustic and midbrain stimulation: investigating a deep brain stimulator for tinnitus. J Neural Eng. 2014 Dec;11(6):066001.

Straka MM, Schmitz S, Lim HH. Response features across the auditory midbrain reveal an organization consistent with a dual lemniscal pathway. J Neurophysiol. 2014 Aug 15;112(4):981-98.

Straka MM, McMahon M, Markovitz CD, Lim HH. Effects of location and timing of co-activated neurons in the auditory midbrain on cortical activity: implications for a new central auditory prosthesis. J Neural Eng. 2014 Aug;11(4):046021.

Straka MM, Schendel D, Lim HH. Neural integration and enhancement from the inferior colliculus up to different layers of auditory cortex.J Neurophysiol. 2013 Aug;110(4):1009-20.

Markovitz CD, Tang TT, Lim HH. Tonotopic and localized pathways from primary auditory cortex to the central nucleus of the inferior colliculus. Front Neural Circuits. 2013 Apr 25;7:77.

Johnson MD, Lim HH, Netoff TI, Connolly AT, Johnson N, Roy A, Holt A, Lim KO, Carey JR, Vitek JL, He B. Neuromodulation for brain disorders: challenges and opportunities. IEEE Trans Biomed Eng. 2013 Mar;60(3):610-24.

Lim HH, Lenarz M, Joseph G, Lenarz T. Frequency representation within the human brain: stability versus plasticity. Sci Rep. 2013;3:1474.

Markovitz CD, Tang TT, Edge DP, Lim HH. Three-dimensional brain reconstruction of in vivo electrode tracks for neuroscience and neural prosthetic applications. Frontiers in Neural Circuits 6(39), 2012.

Calixto R, Lenarz M, Neuheiser A, Scheper V, Lenarz T, Lim HH. Coactivation of different neurons within an isofrequency lamina of the inferior colliculus elicits enhanced auditory cortical activation. Journal of Neurophysiology 108(4): 1199-210, 2012.

Lim HH, Lenarz M, Lenarz T. Midbrain Auditory Prostheses. In: Auditory Prostheses: Cochlear Implants and Beyond, edited by Zeng F-G, Fay RR and Popper AN. Published by Springer Handbook of Auditory Research, 2011.

Lim HH, Lenarz M, Lenarz T. Auditory midbrain implant: a review. Trends Amplif. 2009 Sep;13(3):149-80.

Neuheiser A, Lenarz M, Reuter G, Calixto R, Nolte I, Lenarz T, Lim HH. Effects of pulse phase duration and location of stimulation within the inferior colliculus on auditory cortical evoked potentials in a guinea pig model. Journal of the Association for Research in Otolaryngology , In Press (2010)

Lim HH, Lenarz M, Lenarz T. Auditory Midbrain Implant: A Review. Trends in Amplification 13(3): 149-180, 2009 ( Featured article)

Wenzel GI, Balster S, Zhang K, Lim HH, Reich U, Massow O, Lubatschowski H, Ertmer W, Lenarz T, Reuter G. Green laser light activates the inner ear. Journal of Biomedical Optics 14(4): 044007, 2009

Lim HH, Lenarz T, Joseph G, Battmer RD, James F. Patrick, Lenarz M. Effects of phase duration and pulse rate on loudness and pitch percepts in the first auditory midbrain implant patients: Comparison to cochlear implant and auditory brainstem implant results. Neuroscience 154(1): 370-380, 2008

Lim HH, Lenarz T, Joseph G, Battmer RD, Samii A, Samii M, Patrick JF, Lenarz M. Electrical stimulation of the midbrain for hearing restoration: Insight into the functional organization of the human central auditory system. Journal of Neuroscience 27(49): 13541-13551, 2007 (Featured article)

Lim HH, Anderson DJ. Spatially distinct functional output regions within the central nucleus of the inferior colliculus: Implications for an Auditory Midbrain Implant. Journal of Neuroscience 27(32): 8733-8743, 2007 (Featured article)

Lim HH, Anderson DJ. Antidromic activation reveals tonotopically organized projections from primary auditory cortex to the central nucleus of the inferior colliculus in guinea pig. Journal of Neurophysiology 97: 1413-1427, 2007

Lim HH, Anderson DJ. Auditory cortical responses to electrical stimulation of the inferior colliculus: Implications for an auditory midbrain implant. Journal of Neurophysiology 96: 975-988, 2006

Hubert Lim