James Ashe, M.D.

Professor, Departments of Neuroscience and Neurology

E-MAIL: ashe@umn.edu

Research Interests:

My primary research interest is in the neural control of action in the most general sense.  To address this issue, we use standard behavioral approaches, functional imaging in humans, and direct neural recording from areas in the frontal cortex of non-human primates.

Specific Projects:
(1) Motor learning of new dynamic environments.  We have been examining the neural control of adaptation and learning in specific physical environments, usually in the form of state dependent force fields. At a conceptual level the work focuses on the learning, storage, and consolidation of and interference with internal models of motor behavior. At a translational level, the work is related to making brain mchine iterface (BMI) technology more adaptive to changing motor environments.

(2) Neural basis and mechanisms of motor learning in probabilistic environments.  We examine how subjects use probabilistic information and predictability in their immediate environment to shape their actions and behavior.  The learning behaviors we study range from complex probabilistic patterns to deterministic sequences.

(3) Neural control of complex spatial-temporal sequential behavior. This project examines the neural mechanisms of controlling both the spatial and the temporal components of sequences of movement. It will enable us to answer questions such as (i) Are the spatial and temporal aspects of behavior controlled independently?, and (ii) Does the brain represent abstract time and the temporal components of behavior in a similar way. 

(4) The modulation of action through reward. Much of our behavior is shaped by rewards (both external and internal); we have recently begun to examine how reward (and punishment) influences motor learning.  Disruption of the reward-action system may be a fundamental problem in some disease conditions such as Parkinsons disease.

(5) Decoding of force output from neural signals in frontal cortex.  Current BMI technology applied to the neural control of prosthetic devices has focused almost exclusively on trajectory control.  Accurate decoding of force will be necessary for the development of functinal neural prostheses. For this project, we use a number of innovative approaches to decode force from different neural signals (single cell activity, multi-unit activity, LFP and ECoG). Done in collaboration with Giuseppe Pellizzer (Neuroscience), Firat Ince (Electrical Engineering), and Ahmed Tewfik (Electrical Engineering, UT Austin).

Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Lungu OV, Bares M, Liu T, Gomez CM, Cechova I, Ashe J. Trial-to-trial Adaptation: Parsing out the Roles of Cerebellum and BG in Predictive Motor Timing. J Cogn Neurosci. 2016 Mar 4;:1-15.

Lu X, Ashe J. Dynamic reorganization of neural activity in motor cortex during new sequence production. Eur J Neurosci. 2015 Jun 9.

Ashe J, Bushara K. The olivo-cerebellar system as a neural clock. Adv Exp Med Biol. 2014;829:155-65.

Wu X, Ashe J, Bushara KO. Role of olivocerebellar system in timing without awareness. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13818-22. Epub 2011 Aug 1.

Gowreesunker B, Tewfik A, Tadipatri V, Ashe J, Pellizzer G, Gupta R (2011).  Subspace Approach to Learning Recurrent Features From Brain Activity.  IEEE Trans Neural Syst Rehabil Eng. 2011 Jan 20.

Ince NF, Gupta R, Arica S, Tewfik AH, Ashe J, Pellizzer G. High accuracy decoding of movement target direction in non-human primates based on common spatial patterns of local field potentials. PLoS One. 2010 Dec 21;5(12):e14384.

Wu X, Nestrasil I, Ashe J, Tuite P, Bushara K. Inferior olive response to passive tactile and visual stimulation with variable interstimulus intervals. Cerebellum. 2010 Dec;9(4):598-602.

Ince NF, Gupte A, Wichmann T, Ashe J, Henry T, Bebler M, Eberly L, Abosch A. Selection of optimal programming contacts based on local field potential recordings from subthalamic nucleus in patients with Parkinson's disease. Neurosurgery. 2010 Aug;67(2):390-7.

Bares M, Lungu OV, Liu T, Waechter T, Gomez CM, Ashe J (2010) The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia. Cerebellum. Nov 26.

Ince NF, Gupta R, Arica S, Tewfik AH, Ashe J, Pellizzer G (2010) High accuracy
decoding of movement target direction in non-human primates based on common spatial patterns of local field potentials. PLoS One  5(12):e14384.

Tadipatri VA, Tewfik AH, Gowreesunker B, Ashe J, Pellizzer G, Gupta R (2010). Time robust movement direction decoding in Local Field Potentials using channel ranking. Conf Proc IEEE Eng Med Biol Soc 1:4825-8. 

Current Graduate Students:

Derek Dziobek (Neuroscience, University of Minnesota).

Former Graduate Students:

Alexandra Basford (Ph.D. 2008, Neuroscience, University of Minnesota).

Stephen Kerrigan (Ph.D. 2014, Neuroscience, University of Minnesota).

James Ashe