Cell adhesion is essential to the development of nervous system, from neuronal migration to axon guidance and synapse formation, as well as the maintenance of neural integrity against environmental forces. To understand how cell adhesion molecules function in such a wide spectrum of events, we focus on the L1 family of cell adhesion receptors, using genetic, molecular, and biochemical approaches to dissect their functions and mechanisms of action. Mutations in the human L1CAMs can result in numerous neurological syndromes that include the L1 syndrome, autism, and susceptibility to addiction.
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Opperman, K., Moseley-Alldredge, M., Yochem, J., Bell, L., Kanayinkal, T., and Chen, L. A novel nondevelopmental role of the SAX-7/L1CAM cell adhesion molecule in synaptic regulation in C. elegans. Genetics 2015; 199:497
Yochem J, Lažetić V, Bell L, Chen L, Fay D. C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting. Dev Biol. 2014 Dec 16;.
Chen L, Vu A, Xu J, Moeller S, Ugurbil K, Yacoub E, Feinberg DA. Evaluation of Highly Accelerated Simultaneous Multi-Slice EPI for FMRI. Neuroimage. 2014 Oct 18;104C:452-459.
Stawicki, T.M., Zhou, K., Yochem, J., Chen, L., Jin, Y. 2011. TRPM channels modulate epileptic-like convulsions via systemic ion homeostasis. Current Biol. 21: 883-8.
Zhou S, Chen L. Neural integrity is maintained by dystrophin in C. elegans. J Cell Biol. 2011 Jan 24;192(2):349-63.
Chen L, Zhou S. "CRASH"ing with the worm: insights into L1CAM functions and mechanisms. Dev Dyn. 2010 May;239(5):1490-501.
Zhou S, Opperman K, Wang X, Chen L. unc-44 Ankyrin and stn-2 gamma-syntrophin regulate sax-7 L1CAM function in maintaining neuronal positioning in Caenorhabditis elegans. Genetics. 2008 Nov;180(3):1429-43.
Wang X, Zhang W, Cheever T, Schwarz V, Opperman K, Hutter H, Koepp D, Chen L. The C. elegans L1CAM homologue LAD-2 functions as a coreceptor in MAB-20/Sema2 mediated axon guidance. J Cell Biol. 2008 Jan 14;180(1):233-46.
Wang X, Kweon J, Larson S, Chen L. A role for the C. elegans L1CAM homologue lad-1/sax-7 in maintaining tissue attachment.Dev Biol. 2005 Aug 15;284(2):273-91.
Chen, L., Ong, B., and Bennett, V. 2001. LAD-1, the C. elegans L1CAM family homologue, has essential cell adhesion roles in the early embryo, participates in cell migration, and is a substrate for phosphotyrosine-based signaling. Journal of Cell Biology 154: 841-855.
Bennett, V. and Chen, L. 2001. Ankyrins and cellular targeting of diverse membrane proteins to physiological sites. Current Opinion in Cell Biology 13:61-67.
Moorthy, S., Chen, L., and Bennett, V. 2000. C. elegans Beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function. Journal of Cell Biology 149: 915-930.