Michelle Corkrum

Entering Class - 2014

Member of MSTP (MD/PhD) program

E-MAIL: mcorkrum@umn.edu

Undergraduate Institution and Major:

Wellesley College, BA, Neuroscience, 2012

Advisor:

Alfonso Araque, Ph.D., Department of Neuroscience

Thesis Committee Members:

Description of Graduate Research:

My project aims to investigate the role of astrocytes in cocaine addiction. Traditionally, astrocytes have been viewed as passive players in brain function; however, astrocytes actively regulate synaptic transmission and plasticity. My project examines the effects of cocaine on astrocyte-neuron interactions in the nucleus accumbens, a primary brain region implicated in addiction.

Research Support:

Ruth L. Kirschstein National Research Service Award (F30DA042510), 2016-2019

Published Abstracts:

  • Corkrum M, Covelo A, Quintana R, Loke K, Araque A. Dopamine regulates synaptic transmission in the nucleus accumbens via the activation of astrocytes. GLIA Edinburgh 2017: Abstracts Oral Presentations, Posters, Indexes. Glia, 65: E103–E578. doi:10.1002/glia.23157
  • Corkrum M, Covelo A, Quintana R, Loke K, Araque A. Dopamine-evoked synaptic regulation in the brain reward system requires astrocyte activity. 2017 NIDA-NIAAA Mini-Convention: Frontiers in Addiction Research. https://apps1.seiservices.com/nida-niaaa/frontiers2017/Abstracts_Biograp...

Invited Talks:

  • Corkrum M. Astrocytes mediate brain reward signaling in the nucleus accumbens. University of Minnesota Graduate program of Neuroscience Annual Retreat (February, 2018, Minneapolis, MN).
  • Corkrum M. The role of astrocytes in drug addiction. American Academy of Child and Adolescent Psychiatry Annual Meeting (October, 2015, San Antonio, TX).

Graduate Level Presentations:

  • Corkrum M, Thai M. Horek N, Albott CS, Klimes-Dougan B, Lim KO, Cullen KR. Safety and clinical efficacy evaluation of deep transcranial magnetic stimulation in adolescence with treatment resistant depression. Minnesota Neuromodulation Symposium (April, 2018, Minneapolis, MN). Poster Presentation
  • Corkrum M, Covelo A, Quintana R, Loke K, Araque A. Dopamine regulates synaptic transmission in the nucleus accumbens via the activation of astrocytes. European Meeting on Glial cells in Health and Disease (July, 2017, Edinburgh, Scotland). Poster Presentation
  • Corkrum M. Astrocytes: The hidden stars of treating drug addiction. University of Minnesota 3-Minute Thesis Competition (May, 2017, Minneapolis MN). Oral Presentation, People’s Choice Award.
  • Corkrum M. Astrocytes mediate dopaminergic signaling in the nucleus accumbens core. University of Minnesota Graduate program of Neuroscience Colloquium Series (March, 2017, Minneapolis, MN). Oral Presentation
  • Corkrum M, Covelo A, Quintana R, Araque A. Amphetamine depresses nucleus accumbens synaptic transmission via astrocyte signaling. University of Minnesota Wallin Neuroscience Discovery Day (February, 2017, Minneapolis, MN). Poster Presentation
  • Corkrum M. Astrocyte-neuron Signaling in the Reward System. University of Minnesota Graduate program of Neuroscience Colloquium Series (May, 2016, Minneapolis, MN). Oral Presentation
  • Corkrum M, Covelo A, Araque A. Astrocyte-neuron Signaling in the Reward System. University of Minnesota Wallin Neuroscience Discovery Day (April, 2016, Minneapolis, MN). 1st Place Poster
  • Corkrum M, Covelo A, Araque A. The effects of cocaine on astrocyte-neuron signaling in the nucleus accumbens. International Astrocyte School Conference (April, 2016, Bertinoro, Italy). Oral Presentation
  • Corkrum M, Covelo A, Araque A. Astrocyte-neuron Signaling in Reward. University of Minnesota Graduate program of Neuroscience Annual Retreat (February, 2016, Minneapolis, MN). Poster
  • Corkrum M, Covelo A, Araque A. Astrocyte-neuron Signaling in Reward. Institute for Translational Neuroscience Research Retreat (January, 2016, Minneapolis, MN). Poster
  • Corkrum M. Role of Astrocyte Neuromodulation in Drug Addiction. University of Minnesota Medical Scientist Training Program Annual Retreat (July, 2015, Duluth, MN). Oral Presentation
  • Corkrum M. Astrocytes and Drug Addiction. National Institute of Mental Health MD/PhD Student Conference (November, 2014, San Francisco, CA). Oral Presentation

Research Categories:

  • Drug Abuse & Addiction
  • Synaptic Plasticity & Learning

Graduate Level Awards And Honors:

  • American Academy of Child and Adolescent Psychiatry Life Members
    Mentorship Grant for Medical Students, 2015.
  • American Psychiatric Association Minority Medical Student Scholarship: Annual Meeting, 2015.
  • National Institute of Mental Health MD/PhD student conference travel award, 2014.

Rotations:

Other Committee Involvement:

  • MSTP (MD/PhD) Student Admissions Committee, 01/15-Present
  • MSTP (MD/PhD) Retreat Planning Committee, 08/12-08/15
  • MSTP (MD/PhD) Volunteer Committee, 08/14-08/15
  • MSTP (MD/PhD) Newsletter Committee, 08/14-08/15
  • Psychiatry Student Interest Group, Chair, 08/13-05/14
  • MSTP (MD/PhD) Student Advisory Committee 06/12-06/13

Professional Outreach:

  • St Paul Public Library Reading Tutor, 08/14-05/15
  • University of MN Student National Medical Association Pre-med mentor, 08/13-05/14

Why Did You Choose MN?

I was confident that Minnesota would provide the best training for my ultimate career goal of becoming a successful, independent physician-scientist.

Student Mentor and the Best Advice They Gave:

Anja Srienc: All of Anja's advice was helpful!

 

Michelle Corkrum