My laboratory works on understanding the structural and functional features of heparan sulfate proteoglycans in the context of cytokine and morphogen signaling in various types of stem cells. Current efforts are focused on determining how abnormal heparan sulfates accumulated in mucopolysaccharidosis type I (MPS-I; Hurler syndrome) contribute to neurological abnormalities, and testing if intra-cerebroventricular stem cell transplantation will ameliorate neuropathology and behavioral abnormalities in an immunodeficient mouse model of MPS-I.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Shekels LL, Buelt-Gebhardt M, Gupta P. Effect of systemic heparan sulfate haploinsufficiency on steady state hematopoiesis and engraftment of hematopoietic stem cells. Blood Cells Mol Dis. 2015 Jun;55(1):3-9.
Shekels LL, Colvin Wanshura LE, Xie Y, Nelson MS, Stephenson EJ, Khan SA, Gupta P. The effects of Gremlin1 on human umbilical cord blood hematopoietic progenitors. Blood Cells Mol Dis. 2015 Jan;54(1):103-9.
Zylla D, Kuskowski MA, Gupta K, Gupta P. Association of opioid requirement and cancer pain with survival in advanced non-small cell lung cancer. Br J Anaesth. 2014 Oct 10.
Nguyen J, Luk K, Vang D, Soto W, Vincent L, Robiner S, Saavedra R, Li Y, Gupta P, Gupta K. Morphine stimulates cancer progression and mast cell activation and impairs survival in transgenic mice with breast cancer. Br J Anaesth. 2014 Jul;113 Suppl 1:i4-13.
Lamba JK, Fridley BL, Ghosh TM, Yu Q, Mehta G, Gupta P. Genetic variation in platinating agent and taxane pathway genes as predictors of outcome and toxicity in advanced non-small-cell lung cancer. Pharmacogenomics. 2014;15(12):1565-74.
Wang X, Owzar K, Gupta P, Larson RA, Mulkey F, Miller AA, Lewis LD, Hurd D, Vij R, Ratain MJ, Murry DJ. Vatalanib population pharmacokinetics in patients with myelodysplastic syndrome (MDS): CALGB 10105 (Alliance). Br J Clin Pharmacol 2014; 78(5):1005-13.
Zylla D, Gourley BL, Vang D, Jackson S, Boatman S, Lindgren B, Kuskowski MA, Le C, Gupta K, Gupta P. Opioid requirement, opioid receptor expression, and clinical outcomes in patients with advanced prostate cancer. Cancer. 2013 Dec 1;119(23):4103-10.
Gupta P, Mulkey F, Hasserjian RP, Sanford BL, Vij R, Hurd DD, Odenike OM, Bloomfield CD, Owzar K, Stone RM, Larson RA; Alliance for Clinical Trials in Oncology. A phase II study of the oral VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK222584) in myelodysplastic syndrome: Cancer and Leukemia Group B study 10105 (Alliance). Invest New Drugs. 2013 Oct;31(5):1311-20.
Abraham A, Habermann EB, Rothenberger DA, Kwaan M, Weinberg AD, Parsons HM, Gupta P, Al-Refaie WB. Adjuvant chemotherapy for stage III colon cancer in the oldest old: results beyond clinical guidelines. Cancer. 2013 Jan 15;119(2):395-403.
Zadroga RJ, Zylla D, Cawcutt K, Musher DM, Gupta P, Kuskowski M, Dincer A, Kaka AS. Pneumococcal pyomyositis: report of 2 cases and review of the literature. Clin Infect Dis. 2012 Aug;55(3):e12-7.
Weber ML, Vang D, Velho PE, Gupta P, Crosson JT, Hebbel RP, Gupta K. Morphine promotes renal pathology in sickle mice. Int J Nephrol Renovasc Dis. 2012;5:109-18.
Nan Z, Shekels L, Ryabinin O, Evavold C, Nelson MS, Khan SA, Deans RJ, Mays RW, Low WC, Gupta P. Intra-cerebroventricular transplantation of human bone marrow-derived multipotent progenitor cells in an immunodeficient mouse model of mucopolysaccharidosis type I (MPS-I). Cell Transplantation 2012;21(7):1577-93.
Ninan MJ, Wadhwa PD, Gupta P. Prognostication of diffuse large B-cell lymphoma in the rituximab era. Leuk Lymphoma. 2011; 52(3):360-73.
Kodali D, Rawal A, Ninan MJ, Patel MR, Mesa H, Knapp D, Schnitzer B, Kratzke RA, Gupta P. Expression and phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 in B-cell lymphomas and reactive lymphoid tissues. Arch Pathol Lab Med. 2011; 135(3):365-71.
Wolf DA, Lenander A, Nan Z, Belur L, Whitley CB, Gupta P, Low WC, McIvor RS. Neonatal administration of AAV8 vector directly to the CNS prevents emergence of neurological disease in a murine model of MPS-I. Neurobiol Dis 2011; 43(1):123-33.
Kohli DR, Li Y, Khasabov SG, Gupta P, Simone DA, Kehl LJ, Ericson ME, Gupta V, Hebbel RP, Gupta K. Pain related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: Modulation by cannabinoids. Blood 2010; 116(3):456-65.
Marinier D, Mesa H, Rawal A, Gupta P. Refractory cytopenias with unilineage dysplasia (RCUD): a retrospective analysis of refractory neutropenia and refractory thrombocytopenia. Leuk Lymphoma 2010; 51(10):1923-26.
Luikart SD, Panoskaltsis-Mortari A, Hinkel T, Perri RT, Gupta K, Oegema TR, Gupta P. Mactinin, a fragment of cytoskeletal alpha-actinin, is a novel inducer of heat shock protein (Hsp)-90 mediated monocyte activation. BMC Cell Biol. 2009 Aug 28;10:60.
Aronovich EL, Bell JB, Khan SA, Belur LR, Gunther R, Koniar B, Schachern PA, Parker JB, Carlson CS, Whitley CB, McIvor RS, Gupta P, Hackett PB. Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system. Mol Ther. 2009 Jul;17(7):1136-44.
Khan SA, Nelson MS, Pan C, Gaffney PM, Gupta P. Endogenous heparan sulfate and heparin modulate bone morphogenetic protein-4 signaling and activity. Am J Physiol Cell Physiol. 2008; 294:C1387-1397.