In 1997, Dr. Iaizzo and his coworkers began working on large mammalian isolated heart models, and thus the Visible Heart® laboratory was created in collaboration with Medtronic, Inc. Today, this lab is a premiere place to perform translational systems physiology research. Various CARDIAC-RELATED RESEARCH includes: cardiac physiology, large mammalian comparative cardiac anatomy, cardiac devices/testing/design, electrophysiology/surface/noncontact mapping, pharmacological approaches to cardioprotection, chronic ischemia and/or heart failure models, and opioid preconditioning in human left ventricular trabeculae.
Additional research interests include SKELETAL MUSCLE (anesthetic complications in muscular disorders, stimulated muscle force measurement in neuromuscular diseases, prevention of hypoxic damage using opioid agonists); HIBERNATING BLACK BEARS (hibernation induction triggers, cardiac function and wound healing during hibernation); ELECTROPHYSIOLOGY(intracellular recording and patch clamp techniques, surface or transmural electromyography, action potential mapping); THERMOREGULATION (mechanism of shiver, thermal management of surgical patients, cerebral protection using mild hypothermia, wound formation/treatment/healing, malignant hyperthermia); and SPINAL BIOMECHANICS (cervical spinal unloading, functional rotation and movement of the spine).
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Omdahl P, Eggen MD, Bonner MD, Wika K, Iaizzo PA: Right ventricular anatomy can accommodate multiple transcatheter pacemakers. Pacing & Clinical Electrophysiology (December 2015)
Howard SA, Goff RP, Benditt DG, Iaizzo PA: Direct visualization of an iatrogenic septal defect in a reanimated human heart. Heart Rhythm Case Reports (in press, 2015).
Benscoter MA, Iaizzo PA: Assessing the relative integrity of formed linear lesions by recording both focal and monophasic action potential and contact forces: a technical brief. Journal of Translational Engineering in Health and Medicine (in press, 2015)
Benscoter MA, Iaizzo PA: Visualization of catheter ablation for atrial fibrillation: impact of devices and anatomy. World Journal of Cardiology 7:754-764, 2015.
Ginz HF, Iaizzo PA: Isometric skeletal muscle force measurement in primary myopathies. Muscle and Nerve (in press, 2015).
Benscoter MA, Avitall B, Iaizzo PA: Visualization of an innovative approach for mitral isthmus ablation. Journal of Integrative Cardiology (in press, 2015).
Quallich SG, Kriege KE, Iaizzo, PA: The effects of radiofrequency or cryothermal ablation on biomechanical properties of isolated human or swine cardiac tissues. Journal of Translational Engineering in Health and Medicine 4:1-5, 2015.
Ditmer MA, Garshelis DL, Noyce KV, Laske TG, Iaizzo PA, Burk TE, Forester JD, Fieberg JR: Behavioral and physiological responses of American black bears to landscape features within an agricultural region. Ecosphere 6 (in press, 2015).
Quallich SG, Goff RP, Iaizzo PA: Direct visualization of induced steam pops during radiofrequency ablation. Heart Rhythm Case Reports (in press, 2015)
Burzotta F, Cook B, Iaizzo PA, Singh J, Louvard Y, Latib A: Coronary bifurcations as you have never seen them: the Visible Heart® Laboratory bifurcation programme. EuroIntervention 11 Suppl V:V1-5, 2015.
Zhongping Y, Eggen MD, Marquardt KR, Aselson AJ, McVenes RD, Iaizzo PA: Direct visualization of an atrial transseptal left ventricular endocardial lead implantation within an isolated heart. Heart Rhythm Case Reports 1:107-109, 2015.
Ditmer MA, Vincent JB, Werden LK, Tanner JC, Laske TG, Iaizzo PA, Garshelis DL, Fieberg JR. Bears Show a Physiological but Limited Behavioral Response to Unmanned Aerial Vehicles. Curr Biol. 2015 Aug 31;25(17):2278-83.
Goff RP, Spencer JH, Iaizzo PA. MRI Reconstructions of Human Phrenic Nerve Anatomy and Computational Modeling of Cryoballoon Ablative Therapy. Ann Biomed Eng. 2015 Jul 14.
Spencer JH, Goff RP, Iaizzo PA. Left phrenic nerve anatomy relative to the coronary venous system: Implications for phrenic nerve stimulation during cardiac resynchronization therapy. Clin Anat. 2015 Jul;28(5):621-6.
Colbert RW, Holley CT, Stone LH, Crampton M, Adabag S, Garcia S, Iaizzo PA, Ward HB, Kelly RF, McFalls EO. The Recovery of Hibernating Hearts Lies on a Spectrum: from Bears in Nature to Patients with Coronary Artery Disease. J Cardiovasc Transl Res. 2015 Jun;8(4):244-52.
Howard SA, Quallich SG, Benscoter MA, Holmgren BC, Rolfes CD, Iaizzo PA. Tissue properties of the fossa ovalis as they relate to transseptal punctures: a translational approach. J Interv Cardiol. 2015 Feb;28(1):98-108.
Quallich SG, Van Heel M, Iaizzo PA. Optimal contact forces to minimize cardiac perforations before, during, and/or after radiofrequency or cryothermal ablations. Heart Rhythm. 2015 Feb;12(2):291-6.
Laske TG, Garshelis DL, Iaizzo PA. Big data in wildlife research: remote web-based monitoring of hibernating black bears. BMC Physiol. 2014 Dec 11;14:13.
Eggen MD, Bonner MD, Williams ER, Iaizzo PA. Multimodal imaging of a transcatheter pacemaker implantation within a reanimated human heart. Heart Rhythm. 2014 Dec;11(12):2331-2.
Goff RP, Bersie SM, Iaizzo PA. In vitro assessment of induced phrenic nerve cryothermal injury. Heart Rhythm. 2014 Oct;11(10):1779-84.
Spencer JH, Sundaram CC, Iaizzo PA. The relative anatomy of the coronary arterial and venous systems: implications for coronary interventions. Clin Anat. 2014 Oct;27(7):1023-9.
Spencer JH, Prahl G, Iaizzo PA. The prevalence of coronary sinus and left circumflex artery overlap in relation to the mitral valve. J Interv Cardiol. 2014 Jun;27(3):308-16.
Spencer JH, Larson AA, Drake R, Iaizzo PA. A detailed assessment of the human coronary venous system using contrast computed tomography of perfusion-fixed specimens. Heart Rhythm. 2014 Feb;11(2):282-8.
Spencer JH, Quill JL, Bateman MG, Eggen MD, Howard SA, Goff RP, Howard BT, Quallich SG, Iaizzo PA. The benefits of the Atlas of Human Cardiac Anatomy website for the design of cardiac devices. Expert Rev Med Devices. 2013 Nov;10(6):729-34.
Spencer J, Fitch E, Iaizzo PA. Anatomical reconstructions of the human cardiac venous system using contrast-computed tomography of perfusion-fixed specimens. J Vis Exp. 2013 Apr 18;(74).
Howard SA, Quill JL, Eggen MD, Swingen CM, Iaizzo PA. Novel imaging of atrial septal defects in isolated human hearts. J Cardiovasc Transl Res. 2013 Apr;6(2):218-20.
Spencer JH, Anderson SE, Iaizzo PA. Human coronary venous anatomy: implications for interventions. J Cardiovasc Transl Res. 2013 Apr;6(2):208-17.
Howard SA, Bateman MG, Hill AJ, Anderson RH, Iaizzo PA. In vitro images of a double orifice mitral valve in a reanimated human heart. Ann Thorac Surg. 2013 Apr;95(4):1456.
Bateman MG, Iaizzo PA. Imaging in the context of replacement heart valve development: use of the Visible Heart® methodologies. Cardiovasc Diagn Ther. 2012 Sep;2(3):220-30.
Liu C, Eggen MD, Swingen CM, Iaizzo PA, He B. Noninvasive mapping of transmural potentials during activation in swine hearts from body surface electrocardiograms. IEEE Trans Med Imaging. 2012 Sep;31(9):1777-85.
Richardson ES, Rolfes C, Woo OS, Elmquist WF, Benditt DG, Iaizzo PA. Cardiac responses to the intrapericardial delivery of metoprolol: targeted delivery compared to intravenous administration. J Cardiovasc Transl Res. 2012 Aug;5(4):535-40.
Shrivastav M, Ghai MB, Singal A, Iaizzo PA. The design and use of an optical mapping system for the study of intracardiac electrical signaling. Indian Pacing Electrophysiol J. 2012 Jul;12(4):138-51.
Eggen MD, Swingen CM, Iaizzo PA. Ex vivo diffusion tensor MRI of human hearts: relative effects of specimen decomposition. Magn Reson Med. 2012 Jun;67(6):1703-9.
Bandschapp O, Soule CL, Iaizzo PA. Lactic acid restores skeletal muscle force in an in vitro fatigue model: are voltage-gated chloride channels involved? Am J Physiol Cell Physiol. 2012 Apr 1;302(7):C1019-25.
Iaizzo PA, Laske TG, Harlow HJ, McClay CB, Garshelis DL. Wound healing during hibernation by black bears (Ursus americanus) in the wild: elicitation of reduced scar formation. Integr Zool. 2012 Mar;7(1):48-60.
Eggum JH, Howard SA, Goff RP, Iaizzo PA. Imaging of a coronary artery stent implantation within an isolated human heart. J Cardiovasc Transl Res. 2012 Feb;5(1):73-4.
Cressman EN, Shenoi MM, Edelman TL, Geeslin MG, Hennings LJ, Zhang Y, Iaizzo PA, Bischof JC. In vivo comparison of simultaneous versus sequential injection technique for thermochemical ablation in a porcine model. Int J Hyperthermia. 2012;28(2):105-12.
Cressman EN, Geeslin MG, Shenoi MM, Hennings LJ, Zhang Y, Iaizzo PA, Bischof JC. Concentration and volume effects in thermochemical ablation in vivo: results in a porcine model. Int J Hyperthermia. 2012;28(2):113-21.
Tsang W, Bateman MG, Weinert L, Pellegrini G, Mor-Avi V, Sugeng L, Yeung H, Patel A, Hill AJ, Iaizzo PA, Lang RM: Accuracy of aortic annular measurements obtained from three-dimensional echocardiography, CT and MRI: human in vitro and in vivo studies. Heart (in press) 2012.
Bandschapp O, Goff R, Mallin G, Loushin M, Iaizzo PA: The path of a pulmonary artery catheter visualized through a beating human heart. American Journal of Respiratory and Critical Care Medicine (in press) 2012.