The Spinal Locomotor Circuit of the Larval Zebrafish: Anatomical Organization and Functional Components
Senior Computational Biologist, Vizgen
Postdoctoral Fellow, Brandeis University
Undergraduate Institution and Major/Degree:
- University of Michigan, B.S., Cellular and Molecular Biology, 2004.
Vertebrate locomotion is coordinated by neural circuits in the spinal cord called central pattern generators (CPGs). Spinal cord injury (SCI) can result in severe disruption of the spinal CPG, and repairing the spinal cord following SCI will require an understanding of the locomotor CPG. My work is focused on the role of a specific group of ventral neurons in the CPG by measuring their necessity locomotion, pattern of activity, and intrinsic membrane properties.
Selected Publications and Presentations:
- Wiggin TD, Montgomery JE, Brunick AJ, Peck JH, Masino MA. V3 interneurons are active and recruit spinal motor neurons during in vivo fictive swimming in larval zebrafish. eNeuro. 2022 Mar 10:ENEURO.0476-21.2022.
- Montgomery JE, Wiggin TD, Rivera-Perez LM, Lillesaar C, Masino MA. Intraspinal serotonergic neurons consist of two, temporally distinct populations in developing zebrafish. Dev Neurobiol. 2016;76(6):673-87.
- Wiggin TD, Peck JH, Masino MA. Coordination of fictive motor activity in the larval zebrafish is generated by non-segmental mechanisms. PLoS One. 2014 Oct 2;9(10):e109117.
- Wiggin TD, Anderson TM, Eian J, Peck JH, Masino MA. Episodic swimming in the larval zebrafish is generated by a spatially distributed spinal network with modular functional organization. J Neurophysiol. 2012;108(3):925-34.
- James Ashe
- Tay Netoff
Courses Taken Beyond the Core Courses:
- PHSL 5201 - Computational Neuroscience I
- STAT 5021 - Statistical Analysis
- EE 5621 - Physical Optics
- GCD 8008 - Mammalian Gene Transfer
- Paulo Kofuji - Chair
- Mark Masino - Advisor
- Tay Netoff
- Teresa Nick
- Ronald Calabrese
Conferences Attended and Presentations:
- CNS 2012 - Summer 2012
- Society for Neuroscience annual meeting, 2009, 2011
Honors and Awards:
- Organization for Computational Neurosciences Travel Award
- 5th SFN Satellite Symposium on Motor Systems Travel Award
- Stark travel award
- Society for Neuroscience
- Ann Arbor, MI