I am primarily interested in developing and advancing transcranial focused ultrasound for non-surgical neuromodulation in humans. My current research investigates combining tFUS with MRI as well as developing tFUS for stimulation of sub-cortical structures. The ultimate goal of this research is to translate these findings to clinical populations for therapeutic use. In addition, I also conduct research using conventional non-invasive neuromodulatory technologies like TMS and tD/ACS. This research looks at the effect of individual gyral anatomy on electric fields to advance subject-specific neuromodulation. Finally, I have a particular interest in the frontal cortex and how modulation of frontal areas through either disease, age or neuromodulation affect both local and downstream neuronal circuits and ultimately behavior. This research uses a multidisciplinary approach including neuromodulatory techniques TMS, tDCS and tFUS in combination with EEG, evoked potential, fMRI as well as computational methods including finite element modelling (FEM) and dynamic causal modelling (DCM).
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Legon W. Punzell S. Dowlati E. Adams SE. Stiles AB. Moran RJ. (2015). Altered prefrontal excitation/inhibition balance and prefrontal output: Markers of aging in human memory networks. Cer. Cortex.
Neren D. Johnson MD. Legon W. Bachour SP. Ling G. Divani AA. (2015). Vagus nerve stimulation and other neuromodulation methods for treatment of traumatic brain injury. Neurocrit Care.
Mueller J. Legon W. Tyler W.J. (2015). Analysis of transcranial focused ultrasound beam profile sensitivity for neuromodulation of the human brain. arXiv: 1503.02019.
Opitz A. Legon W. Mueller J. Barbour A. Paulus W. Tyler W.J. Is sham cTBS real cTBS? The effect on EEG dynamics. Front.Hum.Neurosci. 08 Jan 2015.
Mueller J. Legon W. Opitz A. Sato T.F. Tyler W.J. (2014). Transcranial focused ultrasound modulates intrinsic and evoked EEG dynamics. Brain Stimul. 7,(6):900-8.
Legon W. Sato T.F. Opitz A. Mueller J. Barbour A. Williams A. Tyler W.J. (2014). Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans. Nature Neuroscience. 17, 322-329.
Legon W. Dionne J.K. and Staines W.R. (2013). Continuous theta burst stimulation of the supplementary motor area: effect upon perception and somatosensory & motor evoked potentials. Brain Stimul, Nov; 6 (6): 877-83.
Opitz A. Legon W. Rowlands A. Paulus W. Bickel W. and Tyler W.J. (2013). Physiological observations validate finite element models for estimating subject-specific electric field distributions induced by transcranial magnetic stimulation of the human motor cortex. NeuroImage, Nov 1; 81: 253-64.
Dionne J.K. Legon W. & Staines W.R. (2013). Cross-modal influences on early somatosensory processing: interaction of vision, touch and task-relevance. Exp Brain Res, May; 226(4): 503-12.
Legon W. Rowlands A. Opitz A. Sato T. Tyler W.J. (2012). Pulsed ultrasound differentially stimulates somatosensory circuits in humans as indicated by EEG and fMRI. PLoS One. 2012;7(12): e51177.
Neva J.L. Legon W. Staines W.R. (2012). Primary motor cortex excitability is modulated with bimanual training. Neurosci Lett. 514(2) 147-151.
Legon W. Dionne J.K. Meehan S.K. Staines W.R. (2010). Non-dominant hand movement facilitates the frontal N30 somatosensory evoked potential. BMC Neuroscience.