Yasushi Nakagawa, Ph.D.

Associate Professor, Department of Neuroscience

E-MAIL: nakagawa@umn.edu

Research Interests:

In our laboratory, we are interested in how early events in brain development such as patterning of the neural tube and cell type specification eventually lead to the formation of specific neuronal connectivity and development of animal behavior. We are particularly interested in the thalamus and brain regions that are connected to the thalamus, including the neocortex. We extensively use mouse genetics and in vivo gene delivery to study: 1) how multiple thalamic nuclei are formed and 2) how the thalamus development influences the formation of mature areas in the neocortex.

Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Vue TY, Lee M, Tan YE, Werkhoven Z, Wang L, Nakagawa Y. Thalamic control of neocortical area formation in mice. J Neurosci. 2013 May 8;33(19):8442-53.

Bluske, KK., Vue, TY., Kawakami, Y., Taketo, MM., Yoshikawa, K., Johnson, JE., and Nakagawa,Y. Beta-catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus. Development.2012 Aug;139(15):2692-702.

Nakagawa, Y., Shimogori, T. Diversity of thalamic progenitor cells and postmitotic neurons. European Journal of Neuroscience. 2012 May;35(10):1554-62.

Lulich JP, Osborne CA, Carvalho M, Nakagawa Y. Effects of a urolith prevention diet on urine compositions of glycosaminoglycans, Tamm-Horsfall glycoprotein, and nephrocalcin in cats with calcium oxalate urolithiasis. Am J Vet Res. 2012 Mar;73(3):447-51.

Saulnier A., Keruzore M., De Clercq S., Bar I., Moers V., Magnani D., Walcher T., Filippis C., Kricha S., Parlier D., Viviani L., Matson CK., Nakagawa Y., Theil T., Götz M., Mallamaci A., Marine JC., Zarkower D., Bellefroid EJ. (2012) The Doublesex Homolog Dmrt5 is Required for the Development of the Caudomedial Cerebral Cortex in Mammals. Cerebral Cortex, Aug 23.

Wang L, Bluske KK, Dickel LK, Nakagawa Y. Basal progenitor cells in the embryonic mouse thalamus - their molecular characterization and the role of neurogenins and Pax6. Neural Dev. 2011 Nov 11;6:35.

Kawakami Y., Marti M., Kawakami H., Itou J., Quach T., Johnson A., Sahara S., O’Leary D.D.M., Nakagawa Y., Lewandoski M., Pfaff S., Evans S. and Izpisua Belmonte, J.C. (2011) Islet1-mediated activation of  the β-catenin pathway is necessary for hindlimb initiation in mice.
Development 138(20): 4465-4473

Aaker J.D., Patineau A.L., Yang H.J., Nakagawa Y., McLoon S.K. and Koyano-Nakagawa N. (2010) Interaction of MTG family proteins with NEUROG2 and ASCL1 in the developing nervous system. Neurosci. Lett. 474(1): 46-51

Bluske KK, Kawakami Y, Koyano-Nakagawa N, Nakagawa Y. Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamus. Dev Dyn. 2009 Dec;238(12):3297-309.

Davidson S., Truong H., Nakagawa Y. and Giesler G.J. Jr. (2010) A microinjection technique for targeting regions of embryonic and neonatal mouse brain in vivo. Brain Res. 1307: 43-52

Aaker J.D., Patineau A.L., Yang H.J., Ewart D.T., Gong W., Li T., Nakagawa Y., McLoon S.K. and Koyano-Nakagawa N. (2009) Feed-back regulation of Neurogenin 2 activity by MTGR1 is required for progression of neurogenesis.
Mol. Cell. Neurosci. 42(4): 267-277

Alishahi A, Koyano-Nakagawa N, Nakagawa Y. (2009) Regional expression of MTG genes in the developing mouse central nervous system. Dev. Dyn.

Vue, TY., Bluske, K., Alishahi, A., Yang, L., Koyano-Nakagawa, N., Novitch, B., and Nakagawa, Y. Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. Journal of Neuroscience. 2009; 29: 4484-4497

Kim, EJ., Battiste, J., Nakagawa, Y., Johnson, JE. Ascl1 (Mash1) lineage cells contribute to discrete cell populations in CNS architecture. Mol. Cell. Neurosci. 2008; 38: 595-606

Vue, TY., Aaker, J., Taniguchi, A., Kazemzadeh, C., Skidmore, JM., Martin, DM., Martin, JF., Treier, M., and Nakagawa, Y Characterization of progenitor domains in the developing mouse thalamus Journal of Comparative Neurology 2007; 505: 73-91

Burns TC, Ortiz-Gonzalez XR, Gutierrez-Perez M, Keene CD, Sharda R, Demorest ZL, Jiang Y, Nelson-Holte M, Soriano M, Nakagawa Y, Luquin MR, Garcia-Verdugo JM, Prosper F, Low WC, Verfaillie CM. Thymidine analogs are transferred from prelabeled donor to host cells in the central nervous system after transplantation: a word of caution. Stem Cells. 2006 Apr;24(4):1121-7.

Former Graduate Students:

Krista Bluske (Ph.D. 2012, Neuroscience, University of Minnesota)

Tou Yia Vue (Ph.D. 2010, Neuroscience, University of Minnesota)