Synapses are the fundamental units of neural communication in the brain. Using multidisciplinary approaches, we study how synaptic structure and function are precisely shaped during development and how their dysfunction leads to neurological disorders. By understanding the physio-pathological roles of critical synaptic proteins at the cellular, circuitry and system levels, we aim to identify novel targets and further develop pharmacological and genetic therapies for neurodevelopmental and neurodegenerative diseases.
Our techniques include multi-electrode patch clamp in vitro and in vivo, two-photon imaging, optogenetics, chemogenetics, mouse behavioral analysis, and transgenic mouse models.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
- Chao OY, Yunger R, Yang YM. Behavioral assessments of BTBR T+Itpr3tf/J mice by tests of object attention and elevated open platform: Implications for an animal model of psychiatric comorbidity in autism. Behav Brain Res. 2018 Mar 13;347:140-147.
- Yang YM, Wang LY. Ageing brains attend a symphony with asynchronous transmitter release. J Physiol. 2017;595(3):613-614.
- Yang YM, Wang W, Fedchyshyn MJ, Zhou Z, Ding JP, Wang LY. Enhancing the fidelity of neurotransmission by activity-dependent facilitation of presynaptic K+ currents. Nat Commun. 2014;5:4564-4577.
- Wang W, Luo J, Hou P, Yang YM, Xiao F, Yuchi M, Qu A, Wang LY, Ding J. Native gating behavior of ion channels in neurons with null-deviation modeling. PLoS One 2013;8:e77105.