Undergraduate Institution and Major:
St. Olaf College, BA, Psychology, 2014
Esther Krook-Magnuson, Ph.D., Department of Neuroscience
Thesis Committee Members:
- Patrick Rothwell, Ph.D., Department of Neuroscience (Chair)
- Timothy Ebner, MD, Ph.D., Department of Neuroscience
- Yasushi Nakagawa, Ph.D., Department of Neuroscience
- Esther Krook-Magnuson, Ph.D., Department of Neuroscience
Description of Graduate Research:
My research explores inhibitory neuronal circuitry, diversity, and specificity of function in healthy and epileptic rodent brains, with an emphasis on long-range projecting inhibitory neurons of the hippocampus. Techniques used in my research include: intersectional genetic and viral approaches to label highly specific neuron populations, electrophysiology including whole-cell patch clamp recordings, optogenetics in slice preparations and in vivo, stereotaxic surgery, immunohistochemistry, fluorescent confocal microscopy, and whole brain tissue clearing and imaging.
- Neural Circuitry & Diversity
- Neurodegenerative Diseases & Neural Injury
- Stan Thayer, Ph.D., Department of Pharmacology
- Timothy Ebner, M.D., Ph.D., Department of Neuroscience
- Karen Echeverri, Ph.D., Department of Genetics, Cell Biology, and Development
- Esther Krook-Magnuson, Ph.D., Department of Neuroscience
Graduate Level Publications:
Christenson Wick Z, Krook-Magnuson E. Specificity, versatility, and continual development: The power of optogenetics for epilepsy research. Front Cell Neurosci. 2018 Jun 14;12:151.
Christenson Wick Z, Leintz CH, Xamonthiene C, Huang BH, Krook-Magnuson E. Axonal sprouting in commissurally projecting parvalbumin-expressing interneurons. J Neurosci Res. 2017;95(12):2336-2344.
Graduate Level Abstracts:
Christenson Wick Z, Leintz C, Xamonthiene C, Huang B, Krook-Magnuson E. Axonal sprouting in commissurally projecting parvalbumin-expressing interneurons. Inhibition in the CNS. Gordon Research Conference, Les Diablerets, Switzerland. June, 2017.
Christenson Wick Z, Leintz C, Xamonthiene C, Huang B, Krook-Magnuson E. Axonal sprouting in commissurally projecting parvalbumin-expressing interneurons. Society for Neuroscience Annual Meeting, San Diego, CA. November, 2016.
Axonal sprouting of commissurally projecting parvalbumin-expressing interneurons in experimental epilepsy. (June, 2017). Inhibition in the CNS. Development and Plasticity of Inhibition. Gordon Research Seminar, Les Diablerets, Switzerland.
Axonal sprouting of commissurally-projecting parvalbumin-expressing interneurons in experimental temporal lobe epilepsy. (June, 2017). The hippocampal network in humand and experimental epilepsy. Spring Hippocampal Research Conference, Taormina, Sicily.
On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy. (April, 2017). Biology Saves the World: Nature of Life. University of Minnesota College of Biological Sciences, Minneapolis MN.
On-demand optogenetics for epilepsy. (April, 2017). Neuroscience Capstone Seminar Series. Carleton College, Northfield MN.
Cracking inhibitory circuits in the healthy and epileptic hippocampus. (March, 2017). Graduate Program in Neuroscience Colloquium Series. University of Minnesota, Minneapolis MN.
Long-range projecting GABAergic neurons in temporal lobe epilepsy. (February, 2017). Wallin Neuroscience Discovery Day. University of Minnesota, Minneapolis MN.
Admissions Committee, 2016 – present
Other Committee Involvement:
- Inhibition in the CNS, Gordon Research Seminar, 2017 – present
- Council of Graduate Students Grant Review Committee, 2017
Position: Grant Reviewer
- Science for All, American Indian Magnet School, 2015 – 2017
Position: School Lead & Liaison
- Science for All, Mentor, 2015
- Science for All Mentor, 2015 – present
- Brain Awareness Week, 2014 – present
- Graduate Program of Neuroscience Booth at the Minnesota State Fair, 2014 – 2016
Advanced Professional Degree Consulting Club Internship Program, Summer 2016
Society for Neuroscience, 2014 – present
Why Did You Choose MN?
I chose Minnesota for graduate school because of the emphasis on classes during the first year and, more importantly, because of the supportive and cooperative network of students and faculty. During recruitment weekend it became abundantly clear that the students fostered a really fun, creative, and collaborative community. I was excited about the comprehensive coursework because it is important to me to be trained as a well-rounded neuroscientist with knowledge of topics in neuroscience outside the specific expertise I will develop in my thesis lab.
What Advice Would You Give to a First Year Graduate Student?
Advice #1: All the best advice I ever got was given to me at GPN student gatherings – apple picking, happy hours at Stub & Herb’s, around coffee after colloquium, at Career Facilitation Committee dinners… Ask any student any question, and they will give you their best and most honest answer as well as guide you towards all the other people who have had relevant experiences.
Advice #2: Things to consider when choosing an advisor (in my opinion) are: 1) the advisor’s mentorship style (Is it hands-on enough? Is it too hands-on? Will they commit the desired amount of time and energy to you?), 2) the day-to-day activities in the lab (Will you like sitting in front of a computer all day? Do you like having a diverse array of experiments to run, or do you like to really focus on one technique?), and 3) the lab environment (Do you enjoy the company of your future co-workers? Can you stay focused and motivated in the lab space?). I think one of the less important factors in choosing an advisor is the area of research – the research you do in your PhD thesis will probably not dictate what field you go into for the rest of your career, but it will have a long-lasting influence over the techniques you use and master, the way you design and implement experiments, and the way you communicate and disseminate your findings.