|
|
 |
Cerebrovascular Disease
The Cerebral Ischemia and Neurotoxicity
Program addresses basic and applied aspects of research
in the field of cerebral ischemia and stroke. One area
of research focuses on the basic mechanisms regulating
the cerebral circulation and on approaches to monitor
cerebral blood flow non-invasively in the human brain.
A second area of inquiry involves the mechanisms of cerebral
ischemic injury and strategies for brain protection. At
the molecular level, we are studying the molecular programs
activated by brain ischemia. At the cellular level, neuronal
cultures are used to study receptor and second messenger-mediated
events linked to glutamate neurotoxicity and oxygen-glucose
deprivation. At the system level, we are using animal
models of stroke to test strategies for brain protection
suggested by the cellular and molecular studies. A third
area of interest focuses on the mechanisms of functional
recovery after stroke. The reorganization of neural activity
in the human brain following stroke is being mapped using
functional magnetic resonance imaging. |
Graduate Program Faculty
|
|
