William G. Iacono, Ph.D.

Professor, Department of Psychology
E-mail: wiacono@tfs.psych.umn.edu

Research Interests:

My major research interest is the study of severe mental disorders from a psychophysiological, behavior genetic perspective. My primary goal is to identify biological or psychophysiological characteristics that reflect the expression of the gene or genes that predispose individuals to develop schizophrenia or substance-use disorders. In our laboratory, my students and I record eye movements, event-related potentials, and various measures of autonomic nervous system functioning such as skin conductance and heart rate.

Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Hamilton ER, Samek DR, Keyes M, McGue MK, Iacono WG. Identity Development in a Transracial Environment: Racial/Ethnic Minority Adoptees in Minnesota. Adopt Q. 2015;18(3):217-233.

Adolescent drinking and brain morphometry: A co-twin control analysis. Wilson S, Malone SM, Thomas KM, Iacono WG. Dev Cogn Neurosci. 2015 Jul 23. pii: S1878-9293(15)00070-5.

Spain SL, Pedroso I, Kadeva N, Miller MB, Iacono WG, McGue M, Stergiakouli E, Smith GD, Putallaz M, Lubinski D, Meaburn EL, Plomin R, Simpson MA. A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence. Mol Psychiatry. 2015 Aug 4.

Foster KT, Hicks BM, Iacono WG, McGue M. Gender differences in the structure of risk for alcohol use disorder in adolescence and young adulthood. Psychol Med. 2015 Jun 29:1-12.

Männik K, Mägi R, Macé A, Cole B, Guyatt AL, Shihab HA, Maillard AM, Alavere H, Kolk A, Reigo A, Mihailov E, Leitsalu L, Ferreira AM, Nõukas M, Teumer A, Salvi E, Cusi D, McGue M, Iacono WG, Gaunt TR, Beckmann JS, Jacquemont S, Kutalik Z, Pankratz N, Timpson N, Metspalu A, Reymond A. Copy number variations and cognitive phenotypes in unselected populations.JAMA. 2015 May 26;313(20):2044-54.

Genetics of Personality Consortium, de Moor MH, van den Berg SM, Verweij KJ, Krueger RF, Luciano M, Arias Vasquez A, Matteson LK, Derringer J, Esko T, Amin N, Gordon SD, Hansell NK, Hart AB, Seppälä I, Huffman JE, Konte B, Lahti J, Lee M, Miller M, Nutile T, Tanaka T, Teumer A, Viktorin A, Wedenoja J, Abecasis GR, Adkins DE, Agrawal A, Allik J, Appel K, Bigdeli TB, Busonero F, Campbell H, Costa PT, Davey Smith G, Davies G, de Wit H, Ding J, Engelhardt BE, Eriksson JG, Fedko IO, Ferrucci L, Franke B, Giegling I, Grucza R, Hartmann AM, Heath AC, Heinonen K, Henders AK, Homuth G, Hottenga JJ, Iacono WG, Janzing J, Jokela M, Karlsson R, Kemp JP, Kirkpatrick MG, Latvala A, Lehtimäki T, Liewald DC, Madden PA, Magri C, Magnusson PK, Marten J, Maschio A, Medland SE, Mihailov E, Milaneschi Y, Montgomery GW, Nauck M, Ouwens KG, Palotie A, Pettersson E, Polasek O, Qian Y, Pulkki-Råback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Schmidt CO, Slutske WS, Sorice R, Starr JM, St Pourcain B, Sutin AR, Timpson NJ, Trochet H, Vermeulen S, Vuoksimaa E, Widen E, Wouda J, Wright MJ, Zgaga L, Porteous D, Minelli A, Palmer AA, Rujescu D, Ciullo M, Hayward C, Rudan I, Metspalu A, Kaprio J, Deary IJ, Räikkönen K, Wilson JF, Keltikangas-Järvinen L, Bierut LJ, Hettema JM, Grabe HJ, van Duijn CM, Evans DM, Schlessinger D, Pedersen NL, Terracciano A, McGue M, Penninx BW, Martin NG, Boomsma DI. Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. JAMA Psychiatry. 2015 Jul;72(7):642-50.

Samek DR, Elkins IJ, Keyes MA, Iacono WG, McGue M. High School Sports Involvement Diminishes the Association Between Childhood Conduct Disorder and Adult Antisocial Behavior. J Adolesc Health. 2015 Jul;57(1):107-12.

Iacono WG. Neurobehavioral aspects of multidimensional psychopathology. Am J Psychiatry. 2014 Dec 1;171(12):1236-9.

Wilson S, Vaidyanathan U, Miller MB, McGue M, Iacono WG. Premorbid risk factors for major depressive disorder: Are they associated with early onset and recurrent course? Dev Psychopathol. 2014 Nov;26(4 Pt 2):1477-93.

Rietveld CA, Esko T, Davies G, Pers TH, Turley P, Benyamin B, Chabris CF, Emilsson V, Johnson AD, Lee JJ, de Leeuw C, Marioni RE, Medland SE, Miller MB, Rostapshova O, van der Lee SJ, Vinkhuyzen AA, Amin N, Conley D, Derringer J, van Duijn CM, Fehrmann R, Franke L, Glaeser EL, Hansell NK, Hayward C, Iacono WG, Ibrahim-Verbaas C, Jaddoe V, Karjalainen J, Laibson D, Lichtenstein P, Liewald DC, Magnusson PK, Martin NG, McGue M, McMahon G, Pedersen NL, Pinker S, Porteous DJ, Posthuma D, Rivadeneira F, Smith BH, Starr JM, Tiemeier H, Timpson NJ, Trzaskowski M, Uitterlinden AG, Verhulst FC, Ward ME, Wright MJ, Davey Smith G, Deary IJ, Johannesson M, Plomin R, Visscher PM, Benjamin DJ, Cesarini D, Koellinger PD. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13790-4.

Isen JD, Sparks JC, Iacono WG. Predictive validity of delay discounting behavior in adolescence: a longitudinal twin study. Exp Clin Psychopharmacol. 2014 Oct;22(5):434-43.

Irons DE, Iacono WG, McGue M. Tests of the effects of adolescent early alcohol exposures on adult outcomes. Addiction. 2014 Sep 23;.

Bailey JA, Samek DR, Keyes MA, Hill KG, Hicks BM, McGue M, Iacono WG, Epstein M, Catalano RF, Haggerty KP, Hawkins JD. General and substance-specific predictors of young adult nicotine dependence, alcohol use disorder, and problem behavior: replication in two samples. Drug Alcohol Depend. 2014 May 1;138:161-8.

Clark DB, de Wit H, Iacono WG. ADHD, impulsivity and alcohol abuse: methods, results, and implications. Exp Clin Psychopharmacol. 2014 Apr;22(2):141-3.

Hicks BM, Iacono WG, McGue M. Identifying childhood characteristics that underlie premorbid risk for substance use disorders: socialization and boldness. Dev Psychopathol. 2014 Feb;26(1):141-57. PMID: 24280373 [PubMed - in process]

Bailey JA, Samek DR, Keyes MA, Hill KG, Hicks BM, McGue M, Iacono WG, Epstein M, Catalano RF, Haggerty KP, Hawkins JD. General and substance-specific predictors of young adult nicotine dependence, alcohol use disorder, and problem behavior: Replication in two samples. Drug Alcohol Depend. 2014 Feb 26;.

Perlman G, Markin A, Iacono WG. P300 amplitude reduction is associated with early-onset and late-onset pathological substance use in a prospectively studied cohort of 14-year-old adolescents. Psychophysiology. 2013 Aug 2;.

Isen JD, Iacono WG, Malone SM. Characterizing electrodermal response habituation: A latent class approach with application to psychopathology. Psychophysiology. 2013 Jul 4;.

Iacono WG, Malone SM. Developmental Endophenotypes: Indexing Genetic Risk for Substance Abuse with the P300 Brain Event-Related Potential. Child Dev Perspect. 2011 Dec 1;5(4):239-247.

Vrieze SI, McGue M, Miller MB, Legrand LN, Schork NJ, Iacono WG. An assessment of the individual and collective effects of variants on height using twins and a developmentally informative study design. PLoS Genet. 2011 Dec;7(12):e1002413. Epub 2011 Dec 8.

Gilmore CS, Malone SM, Iacono WG. Is the P3 amplitude reduction seen in externalizing psychopathology attributable to stimulus sequence effects? Psychophysiology. 2011 Sep 19. doi: 10.1111/j.1469-8986.2011.01299.x.

Vrieze SI, Perlman G, Krueger RF, Iacono WG. Is the Continuity of Externalizing Psychopathology the Same in Adolescents and Middle-Aged Adults? A Test of the Externalizing Spectrum's Developmental Coherence. J Abnorm Child Psychol. 2011 Sep 20.

Hicks BM, Durbin CE, Blonigen DM, Iacono WG, McGue M. Relationship between personality change and the onset and course of alcohol dependence in young adulthood. Addiction. 2011 Aug 18. doi: 10.1111/j.1360-0443.2011.03617.x.

Kirkpatrick RM, Legrand LN, Iacono WG, McGue M. A Twin and Adoption Study of Reading Achievement: Exploration of Shared-Environmental and Gene-Environment-Interaction Effects. Learn Individ Differ. 2011 Aug 1;21(4):368-375.

Elkins IJ, Malone S, Keyes M, Iacono WG, McGue M. The impact of attention-deficit/hyperactivity disorder on preadolescent adjustment may be greater for girls than for boys. J Clin Child Adolesc Psychol. 2011;40(4):532-45. doi: 10.1080/15374416.2011.581621.

Bornovalova MA, Hicks BM, Iacono WG, McGue M. Familial transmission and heritability of childhood disruptive disorders. Am J Psychiatry. 2010 Sep;167(9):1066-74. Epub 2010 Jul 15. Erratum in: Am J Psychiatry. 2010 Nov;167(11):1414.

Hicks BM, Iacono WG, McGue M. Consequences of an adolescent onset and persistent course of alcohol dependence in men: adolescent risk factors and adult outcomes. Alcohol Clin Exp Res. 2010 May;34(5):819-33. Epub 2010 Feb 24.

Gilmore CS, Malone SM, Iacono WG. Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach. Behav Genet. 2010 Mar;40(2):186-200. Epub 2010 Feb 13.

Malone SM, McGue M, Iacono WG. Mothers' maximum drinks ever consumed in 24 hours predicts mental health problems in adolescent offspring. J Child Psychol Psychiatry. 2010 Sep;51(9):1067-75. Epub 2010 Jan 18.

South SC, Krueger RF, Iacono WG. Factorial invariance of the Dyadic Adjustment Scale across gender. Psychol Assess. 2009 Dec;21(4):622-8.

Bornovalova MA, Hicks BM, Iacono WG, McGue M. Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: a longitudinal twin study. Dev Psychopathol. 2009 Fall;21(4):1335-53.

Keyes MA, Malone SM, Elkins IJ, Legrand LN, McGue M, Iacono WG. The enrichment study of the Minnesota twin family study: increasing the yield of twin families at high risk for externalizing psychopathology. Twin Res Hum Genet. 2009 Oct;12(5):489-501.

Gilmore CS, Malone SM, Bernat EM, Iacono WG.Relationship between the P3 event-related potential, its associated time-frequency components, and externalizing psychopathology. Psychophysiology. 2010 Jan 1;47(1):123-32. Epub 2009 Aug 7.

Iacono WG. Accuracy of polygraph techniques: Problems using confessions to determine ground truth. Physiol Behav. 2008 Jun 10.

Burcusa SL, Iacono WG. Risk for recurrence in depression. Clin Psychol Rev. 2007 Dec;27(8):959-85.

Elkins IJ, McGue M, Iacono WG. Prospective effects of attention-deficit/hyperactivity disorder, conduct disorder, and sex on adolescent substance use and abuse. Arch Gen Psychiatry. 2007 Oct;64(10):1145-52.

Irons DE, McGue M, Iacono WG, Oetting WS. Mendelian randomization: A novel test of the gateway hypothesis and models of gene-environment interplay. Dev Psychopathol. 2007 Fall;19(4):1181-95.

Legrand LN, Keyes M, McGue M, Iacono WG, Krueger RF. Rural environments reduce the genetic influence on adolescent substance use and rule-breaking behavior. Psychol Med. 2007 Oct 1;:1-10

Hicks BM, Blonigen DM, Kramer MD, Krueger RF, Patrick CJ, Iacono WG, McGue M. Gender differences and developmental change in externalizing disorders from late adolescence to early adulthood: A longitudinal twin study. J Abnorm Psychol. 2007 Aug;116(3):433-47.

Nichol PE, Krueger RF, Iacono WG. Investigating gender differences in alcohol problems: a latent trait modeling approach. Alcohol Clin Exp Res. 2007 May;31(5):783-94.

McGue M, Keyes M, Sharma A, Elkins I, Legrand L, Johnson W, Iacono WG. The environments of adopted and non-adopted youth: evidence on range restriction from the Sibling Interaction and Behavior Study (SIBS). Behav Genet. 2007 May;37(3):449-62.

Bernat EM, Malone SM, Williams WJ, Patrick CJ, Iacono WG. Decomposing delta, theta, and alpha time-frequency ERP activity from a visual oddball task using PCA. Int J Psychophysiol. 2007 Apr;64(1):62-74.

Iacono WG. Common and Distinct Genetic/Nongenetic Factors Across Addictions. Annu Rev Clin Psychol. 2007 Mar 2.

Walden B, Iacono WG, McGue M. Trajectories of change in adolescent substance use and symptomatology: impact of paternal and maternal substance use disorders. Psychol Addict Behav. 2007 Mar;21(1):35-43.

Former Graduate Students:

Diane Gooding (Ph.D., Psychology, 1995). Assistant Professor, University of Wisconsin,Madison.

Beth Snitz (Ph.D., Psychology, 1997). Postdoctora; Fellow, University of Tuebingen, Germany.

Alysa Doyle (Ph.D., Psychology, 1998). Research Scientist, Massachusetts general Hospital, Boston, MA.

Clayton Curtis (Ph.D., 1999, Psychology). Postdoctoral Fellow, University of California, Berkeley, CA.

McGuire,K. A. (2000). The utility of spontaneous electroencephalography in research on alcohol dependence and risk for alcohol dependence. Postdictoral fellow, Minneapolis VAMC

Disney,E.R. (2001). The impact of prenatal alcohol or tobacco exposure on later ADHD or CD offspring. Postdoctoral fellow, Johns Hopkins University

Marmorstein,N. R. (2001). The co-occurrence of major depression and conduct disorder in adolescents. (In press, Journal of the American Academy of Child and Adolescent Psychiatry) Assitant Professor, Rutgers University

Conklin,H.M. (2002). Working memory functioning in schizophrenia patients and their first-degree relatives: Cognitive functioning shedding light on etiology. Postdoctoral Fellow, Johns Hopkins University

Calkins,M. (2002). The co-aggregation of smooth pursuit, saccade and fixation eye movement dysfunction in schizophrenia patients and their first degree biological relatives. Postdoctoral fellow, University of Pennsylvania.