My major research interest is the study of severe mental disorders
from a psychophysiological, behavior genetic perspective. My primary
goal is to identify biological or psychophysiological characteristics
that reflect the expression of the gene or genes that predispose
individuals to develop schizophrenia or substance-use disorders.
In our laboratory, my students and I record eye movements, event-related
potentials, and various measures of autonomic nervous system functioning
such as skin conductance and heart rate.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
Iacono WG, Malone SM. Developmental Endophenotypes: Indexing Genetic Risk for Substance Abuse with the P300 Brain Event-Related Potential. Child Dev Perspect. 2011 Dec 1;5(4):239-247.
Vrieze SI, McGue M, Miller MB, Legrand LN, Schork NJ, Iacono WG. An assessment of the individual and collective effects of variants on height using twins and a developmentally informative study design. PLoS Genet. 2011 Dec;7(12):e1002413. Epub 2011 Dec 8.
Gilmore CS, Malone SM, Iacono WG. Is the P3 amplitude reduction seen in externalizing psychopathology attributable to stimulus sequence effects? Psychophysiology. 2011 Sep 19. doi: 10.1111/j.1469-8986.2011.01299.x.
Vrieze SI, Perlman G, Krueger RF, Iacono WG. Is the Continuity of Externalizing Psychopathology the Same in Adolescents and Middle-Aged Adults? A Test of the Externalizing Spectrum's Developmental Coherence. J Abnorm Child Psychol. 2011 Sep 20.
Hicks BM, Durbin CE, Blonigen DM, Iacono WG, McGue M. Relationship between personality change and the onset and course of alcohol dependence in young adulthood. Addiction. 2011 Aug 18. doi: 10.1111/j.1360-0443.2011.03617.x.
Kirkpatrick RM, Legrand LN, Iacono WG, McGue M. A Twin and Adoption Study of Reading Achievement: Exploration of Shared-Environmental and Gene-Environment-Interaction Effects. Learn Individ Differ. 2011 Aug 1;21(4):368-375.
Elkins IJ, Malone S, Keyes M, Iacono WG, McGue M. The impact of attention-deficit/hyperactivity disorder on preadolescent adjustment may be greater for girls than for boys. J Clin Child Adolesc Psychol. 2011;40(4):532-45. doi: 10.1080/15374416.2011.581621.
Bornovalova MA, Hicks BM, Iacono WG, McGue M. Familial transmission and heritability of childhood disruptive disorders. Am J Psychiatry. 2010 Sep;167(9):1066-74. Epub 2010 Jul 15. Erratum in: Am J Psychiatry. 2010 Nov;167(11):1414.
Hicks BM, Iacono WG, McGue M. Consequences of an adolescent onset and persistent course of alcohol dependence in men: adolescent risk factors and adult outcomes. Alcohol Clin Exp Res. 2010 May;34(5):819-33. Epub 2010 Feb 24.
Gilmore CS, Malone SM, Iacono WG. Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach. Behav Genet. 2010 Mar;40(2):186-200. Epub 2010 Feb 13.
Malone SM, McGue M, Iacono WG. Mothers' maximum drinks ever consumed in 24 hours predicts mental health problems in adolescent offspring. J Child Psychol Psychiatry. 2010 Sep;51(9):1067-75. Epub 2010 Jan 18.
South SC, Krueger RF, Iacono WG. Factorial invariance of the Dyadic Adjustment Scale across gender. Psychol Assess. 2009 Dec;21(4):622-8.
Bornovalova MA, Hicks BM, Iacono WG, McGue M. Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: a longitudinal twin study. Dev Psychopathol. 2009 Fall;21(4):1335-53.
Keyes MA, Malone SM, Elkins IJ, Legrand LN, McGue M, Iacono WG. The enrichment study of the Minnesota twin family study: increasing the yield of twin families at high risk for externalizing psychopathology. Twin Res Hum Genet. 2009 Oct;12(5):489-501.
Gilmore CS, Malone SM, Bernat EM, Iacono WG.Relationship between the P3 event-related potential, its associated time-frequency components, and externalizing psychopathology. Psychophysiology. 2010 Jan 1;47(1):123-32. Epub 2009 Aug 7.
Iacono WG. Accuracy of polygraph techniques: Problems using confessions to determine ground truth. Physiol Behav. 2008 Jun 10.
Burcusa SL, Iacono WG. Risk for recurrence in depression. Clin Psychol Rev. 2007 Dec;27(8):959-85.
Elkins IJ, McGue M, Iacono WG. Prospective effects of attention-deficit/hyperactivity disorder, conduct disorder, and sex on adolescent substance use and abuse. Arch Gen Psychiatry. 2007 Oct;64(10):1145-52.
Irons DE, McGue M, Iacono WG, Oetting WS. Mendelian randomization: A novel test of the gateway hypothesis and models of gene-environment interplay. Dev Psychopathol. 2007 Fall;19(4):1181-95.
Legrand LN, Keyes M, McGue M, Iacono WG, Krueger RF. Rural environments reduce the genetic influence on adolescent substance use and rule-breaking behavior. Psychol Med. 2007 Oct 1;:1-10
Hicks BM, Blonigen DM, Kramer MD, Krueger RF, Patrick CJ, Iacono WG, McGue M. Gender differences and developmental change in externalizing disorders from late adolescence to early adulthood: A longitudinal twin study. J Abnorm Psychol. 2007 Aug;116(3):433-47.
Nichol PE, Krueger RF, Iacono WG. Investigating gender differences in alcohol problems: a latent trait modeling approach. Alcohol Clin Exp Res. 2007 May;31(5):783-94.
McGue M, Keyes M, Sharma A, Elkins I, Legrand L, Johnson W, Iacono WG. The environments of adopted and non-adopted youth: evidence on range restriction from the Sibling Interaction and Behavior Study (SIBS). Behav Genet. 2007 May;37(3):449-62.
Bernat EM, Malone SM, Williams WJ, Patrick CJ, Iacono WG. Decomposing delta, theta, and alpha time-frequency ERP activity from a visual oddball task using PCA. Int J Psychophysiol. 2007 Apr;64(1):62-74.
Iacono WG. Common and Distinct Genetic/Nongenetic Factors Across Addictions. Annu Rev Clin Psychol. 2007 Mar 2.
Walden B, Iacono WG, McGue M. Trajectories of change in adolescent substance use and symptomatology: impact of paternal and maternal substance use disorders. Psychol Addict Behav. 2007 Mar;21(1):35-43.
Former Graduate Students:
Diane Gooding (Ph.D., Psychology, 1995). Assistant Professor, University
Beth Snitz (Ph.D., Psychology, 1997). Postdoctora; Fellow, University
of Tuebingen, Germany.
Alysa Doyle (Ph.D., Psychology, 1998). Research Scientist, Massachusetts
general Hospital, Boston, MA.
Clayton Curtis (Ph.D., 1999, Psychology). Postdoctoral Fellow,
University of California, Berkeley, CA.
McGuire,K. A. (2000). The utility of spontaneous electroencephalography
in research on alcohol dependence and risk for alcohol dependence.
Postdictoral fellow, Minneapolis VAMC
Disney,E.R. (2001). The impact of prenatal alcohol or tobacco exposure
on later ADHD or CD offspring. Postdoctoral fellow, Johns Hopkins
Marmorstein,N. R. (2001). The co-occurrence of major depression
and conduct disorder in adolescents. (In press, Journal of the American
Academy of Child and Adolescent Psychiatry) Assitant Professor,
Conklin,H.M. (2002). Working memory functioning in schizophrenia
patients and their first-degree relatives: Cognitive functioning
shedding light on etiology. Postdoctoral Fellow, Johns Hopkins University
Calkins,M. (2002). The co-aggregation of smooth pursuit, saccade
and fixation eye movement dysfunction in schizophrenia patients
and their first degree biological relatives. Postdoctoral fellow,
University of Pennsylvania.