Ion Channels
Brain function is critically dependent on the properties
of neurons and glial cells. Members of the Ion Channels
group study the properties and functions of ligand- and
voltage-gated ion channels in both cell types.
Ongoing investigations explore the molecular structure
of ion channels, their regulation by intracellular signals,
their interactions with scaffolding proteins, and their
role in information processing in the central nervous
system. A variety of techniques is employed, including
the cloning and expression of ion channels in heterologous
systems such as Xenopus oocytes or transfected mammalian
cells, single-channel and whole cell voltage-clamp studies,
and recording of synaptic events in brain slices and cultured
neurons.
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