The University of Minnesota has one of the largest and most highly regarded motor control groups in the world. Research deals primarily with the control of limb movement in three-dimensional space and hand-eye coordination, including the functions of the motor cortex, basal ganglia, cerebellum and cerebellar afferent systems, and the nature of sensorimotor transformations controlling movement. The Motor Control group uses a variety of approaches ranging from a biomechanical description of movement kinematics and kinetics to single unit recording from alert animals and encompassing human psychophysics, functional magnetic resonance imaging, and neural network models. The group studying normal movement is complemented by a large group of researchers studying cerebellar ataxia and other diseases of the motor system. This group uses cellular and molecular approaches including genetics and transgenic mouse models to understand diseases of the motor system.