Neurogenetics
The Neurogenetics group investigates three major areas:
genetic approaches to neurodevelopment, isolation and
characterization of genes involved in human neurological
diseases, and development of transgenic mouse models of
neurological disorders. A major focus of attention in
all three of these areas is the cerebellum. Researchers
study transgenic mouse models of spinocerebellar ataxia
type 1, a disease due to the expansion of an unstable
trinucleotide repeat, of Alzheimer's disease and aging,
and of slow channel syndrome. Genes involved in human
neurological disease are isolated using molecular approaches.
The molecular genetics of neurodevelopment is also an
active area of investigation, including the use of genetics
to study the development of sensory maps in cerebral cortex.
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