Adele DeNicola

Entering Class - 2012

E-MAIL: denic003@umn.edu

Undergraduate Institution And Major:

Boston College, B.S. in Biology and B.A. in Psychology with Honors, Neuroscience Concentration, 2010

Graduate Advisor:

Matthew Chafee, Ph.D. Department of Neuroscience

Thesis Committee Members:

Description of Graduate Research:

My lab studies the neural mechanisms of cognitive control in the context of psychiatric disease. Neuronal activity and information transfer within neural circuits are not well understood in the context of psychiatric disease. My thesis work looks at the underlying mechanisms within the thalamo-cortical network during performance of a cognitive control task to better understand how the thalamus affects cortical processing of cognition.  I will also examine this network in the context of psychiatric disease and whether deep brain stimulation can reduce cognitive deficits associated with psychiatric disease.

    Research Categories

    • Behavioral and Cognitive Neuroscience
    • Neuroengineering
    • Neuropsychiatric Disease

    Graduate Level Awards And Honors:

    • F31 Ruth L. Kirschstein National Research Service Award, 2015
    • American Legion Brain Sciences Family Award, 2015
    • Sping and Ying Ngoh Lin Award, 2015
    • MnDRIVE Neuromodulation Graduate Student Fellowship, 2014

    Graduate Level Publications:

    • Zick JL, Blackman RK, Crowe DA, Amirikian B, DeNicola AL, Netoff TI, Chafee MV. Blocking NMDAR disrupts spike timing and decouples monkey prefrontal circuits: implications for activity-dependent disconnection in Schizophrenia. Neuron. 2018 May 26. pii: S0896-6273(18)30382-9.
    • Blackman RK, Crowe DA, DeNicola AL, Sakellaridi S, MacDonald AW III, Chafee MV. Monkey prefrontal neurons reflect logical operations for cognitive control in a variant of the AX continuous performance task (AX-CPT). J Neurosci. 2016 Apr 6;36(14):4067-79.

    Graduate Level Abstracts:

    • DeNicola, A.L. and Chafee, M.V. 2016. Behavioral dissection of the dot-pattern expectancy task (DPX) in non-human primates. Abstract for poster presentation, Society for Neuroscience Annual Meeting, San Diego, CA

    Professional Presentations:

    • Characterization and modulating primate thalamocortical network dynamics underlying cognitive control. Oral presentation at Department of Neuroscience Colloquium Series, University of Minnesota, Minneapolis, MN, May 6, 2015
    • Career Panel, Oral presentation at Department of Biology, Augsburg College, Minneapolis, MN, December 4, 2015
    • Cognitive control performance errors and thalamocortical dynamics in a monkey model of schizophrenia. Oral presentation at Department of Neuroscience Colloquium Series, University of Minnesota, Minneapolis, MN, May 25, 2016
    • Characterization of neural correlates of cognitive control in the mediodorsal nucleus of the thalamus. Oral Presentation at the Wallin Neuroscience Discovery Day, University of Minnesota, Minneapolis, MN, February 3, 1017
    • Characterizing the neural correlates underlying cognitive control in the MD, ACC, and dlPFC. Oral Presentation at Department of Neuroscience Colloquium Series, University of Minnesota, Minneapolis, MN, May 3, 2017
    • Probing a spike-timing theory of schizophrenia: thalamocortical PFC network dynamics in a primate model. Oral Presentation at 1st Annual Brain Camp, University of Minnesota, Minneapolis, MN, July 21, 2017

    Rotations:

    GPN Committees:

    • Marketing and Recruitment Committee, Founding Member, 2015 - 2017
    • Admissions Committee, 2015 - 2017
    • Mentorship Committee, 2014 - 2016
    • Student Board, First-Year Representative, 2012 - 2013

    Professional Outreach:

    • Volunteer at the Minnesota State Science Bowl, St. Paul, Minnesota, February 2016
    • Volunteer at the Annual Brain Bee Competition, Minneapolis, MN, 2016
    • Brain Awareness Week Instructor, various Schools across the Twin Cities 2013- Present
    • Science Fusion Presenter, Science Museum of Minnesota, October 2014 and 2015
    • Brains at the Fair, Minnesota State Fair University of Minnesota Booth, August 2015
    • MnDrive at the Fair, Minnesota State Fair University of Minnesota Booth, August 2015

    Professional Memberships:

    • Society for Neuroscience, 2015 – present

    Why Did You Choose UMN?

    I chose the UMN because of the interdisciplinary nature of the program and the collaborative environment portrayed to me during the interview weekend. I also very much enjoy all the Twin Cities has to offer outside of the GPN.

    What Advice Would You Give A First Year Graduate Student?
    Give weight to the advice offered up by the upperclassmen; they know what they are talking about because they have been in your shoes.

    Adele DeNicola