Dr. Sophia Vinogradov directs a translational clinical neuroscience laboratory that focuses on cognitive dysfunction in schizophrenia. In collaboration with basic scientists, she studies neuroscience-informed computerized cognitive training exercises for patients with schizophrenia that aim to drive enduring plastic changes in cortical processing. The training programs utilize adaptive algorithms to adjust the difficulty level to maintain a 70-80% correct performance rate, allowing for a customized approach to each individual’s initial performance level and progress rate. Spanning several aspects of cognitive functioning, the exercises fine tune sensory processing speed, working memory, and attention as well as higher-order cognitive processes. In turn, this results in significant improvements in untrained cognitive skills as well as improvements in quality of life. Dr. Vinogradov uses MEG and fMRI methods to probe the brain changes in both early sensory processing and higher-order cognitive operations in subjects who undergo this cognitive training. More recently, she has begun to apply these methods to the study of adolescents who are prodromal for schizophrenia and young adults in early psychosis, with the goal of delaying or preventing the onset of a deteriorating psychiatric illness. Her work has contributed to a growing interest in the use of computerized “brain training” to treat some of the brain information processing abnormalities of psychiatric illnesses.
(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)
- Kantrowitz JT, Swerdlow NR, Dunn W, Vinogradov S. Auditory system target engagement during plasticity-based interventions in schizophrenia: A focus on modulation of N-methyl-D-aspartate-type glutamate receptor function. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Feb 22. pii: S2451-9022(18)30045-4.
- Subramaniam K, Gill J, Fisher M, Mukherjee P, Nagarajan S, Vinogradov S. White matter microstructure predicts cognitive training-induced improvements in attention and executive functioning in schizophrenia. Schizophr Res. 2018;193:276-283.
- Vinogradov S, Nagarajan S. Association of sensory processing with higher-order cognition and functioning in schizophrenia: Mapping the world. JAMA Psychiatry. 2017;74(1):17-18.
- Fisher M, Nahum M, Howard E, Rowlands A, Brandrett B, Kermott A, Woolley J, Vinogradov S. Supplementing intensive targeted computerized cognitive training with social cognitive exercises for people with schizophrenia: An interim report. Psychiatr Rehabil J. 2017;40(1):21-32.
- Ramsay IS, Ma S, Fisher M, Loewy RL, Ragland JD, Niendam T, Carter CS, Vinogradov S. Model selection and prediction of outcomes in recent onset schizophrenia patients who undergo cognitive training. Schizophr Res Cogn. 2017 Nov 8;11:1-5.
- Loewy R, Fisher M, Schlosser DA, Biagianti B, Stuart B, Mathalon DH, Vinogradov S. Intensive auditory cognitive training improves verbal memory in adolescents and young adults at clinical high risk for psychosis. Schizophr Bull. 2016 Jul;42 Suppl 1:S118-26.
- Dale CL, Brown EG, Fisher M, Herman AB, Dowling AF, Hinkley LB, Subramaniam K, Nagarajan SS, Vinogradov S. Auditory cortical plasticity drives training-induced cognitive changes in schizophrenia. Schizophr Bull. 2016;42(1):220-228.
- Fisher M, Loewy R, Carter C, Lee A, Ragland JD, Niendam T, Schlosser D, Pham L, Miskovich T, Vinogradov S. Neuroplasticity-based auditory training via laptop computer improves cognition in young individuals with recent onset schizophrenia. Schizophr Bull. 2015 Jan;41(1):250-8.
- Fisher M, Loewy R, Hardy K, Schlosser D, Vinogradov S. Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophrenia. Annu Rev Clin Psychol. 2013;9:435-63.
- Subramaniam K, Luks TL, Fisher M, Simpson GV, Nagarajan S, Vinogradov S. Computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia. Neuron. 2012;73(4):842-53.