Julia Gamache

Entering Class - 2014

E-MAIL: gamac008@umn.edu

Undergraduate Institution And Major:

Carleton College

Graduate Advisor:

Karen Ashe, M.D., Ph.D., Departments of Neurology and Neuroscience
Michael Koob, Ph.D., Department of Laboratory Medicine and Pathology

Thesis Committee Members:

Description Of Graduate Research:

Tauopathies are a family of diseases, including Alzheimer’s disease and Frontotemporal Dementia (FTD), in which the microtubule-binding protein tau is abnormally regulated. The P301L tau mutation is the most common mutation linked to heritable FTD, and it has been shown to cause tau to mislocalize from neuronal axons to the somatodendritic region. Our laboratory has shown that proteolytic cleavage of tau by caspase-2 is required for mislocalization of P301L tau. To study this pathological process in vivo, we are using novel mouse models harboring a targeted human tau transgene.

Research Categories:

  • Neurodegenerative Diseases & Neural Injury

Graduate Level Awards And Honors:

  • 3M Science and Technology Fellowship, 2014
  • Alzheimer’s Drug Discovery Foundation Young Investigator Scholarship, 2016
  • Ruth L. Kirschstein National Research Service Award (F31), 2017

Graduate Level Publications:

  • Gamache JE, Benzow K, Forster C, Furrow E, Ashe KH, Koob M. Forebrain atrophy in the rTg4510 mouse model of tauopathy is caused by Fgf14 dysregulation by the tau transgene. Nature Medicine. In preparation:

Graduate Level Abstracts:

  • Gamache JE, Furrow, E, Ashe, KH, Koob, M. Tau transgene disrupts FGF14 in the rTg4510 mouse model of tauopathy. Institute for Translational Neuroscience Research Retreat, Minneapolis, MN, 2017.
  • Gamache JE, Furrow, E, Ashe, KH, Koob, M. Tau transgene disrupts FGF14 in the rTg4510 mouse model of tauopathy. Wallin Neuroscience Discovery Day, Minneapolis, MN, 2017.
  • Gamache JE, Ashe KH, Koob M. Disease-related MAPT mutations alter steady-state levels of tau protein Alzheimer’s Drug Discovery Foundation 17th International Conference, Jersey City, NJ, 2016.
  • Gamache JE, Ashe, KH, Koob, M. Disease-related MAPT mutations alter steady-state levels of tau protein. Society for Neuroscience Annual Meeting, San Diego, CA, 2016.

Professional Presentations:

  • Disease-related MAPT mutations alter steady-state Tau levels. N. Bud Grossman Center for Memory Research and Care, Scientist Meeting. University of Minnesota, Minneapolis, MN, 2016.
  • Using precision-engineered mouse models for the study of tauopathy. N. Bud Grossman Center for Memory Research and Care, Scientist Meeting..University of Minnesota, Minneapolis, MN, 2017.
  • Using precision-engineered mouse models for the study of tauopathy. Graduate Program in Neuroscience Colloquium Series. University of Minnesota, Minneapolis, MN, 2017.

Rotations:

GPN Committees:

  • Career Facilitation Committee, Representative, 2015-Present
  • Program Evaluation Committee, Representative, 2016-Present
  • Outreach Committee, Officer, 2016-Present

Professional Outreach:

  • Minnesota Science Museum, Social Science, St. Paul, MN; Undead Rising Event, Brain Booth, September 2015.

Why Did You Choose MN?

I decided the program at the U of MN was the best fit for me because I felt that it would provide me with a stronger knowledge base and more rigorous training experience than the other programs I looked at. Additionally, there were a number of faculty with whom I was interested in working.

What Advice Would You Give A First Year Graduate Student?

Unless you already know what facet of neuroscience you’re passionate about, use the rotations to explore as many different areas or techniques as you can. You might stumble upon something you didn’t realize you’re excited about.

Julia Gamache