Neurotrophic factor treatment to extraocular muscle (EOM) changes motor neuron properties
Data Scientist, Tubi TV
Zipfian Academy, Data Science Fellow
Undergraduate Institution and Major/Degree:
Drake University, B.S., Neuroscience, Psychology, 2004
Strabismus and Infantile nystagmus are two disorders often caused by central nervous system dysinnervation of the extraocular muscles in the orbit. In young children, there is a critical period where normal binocular eye function must be returned, or amblyopia can occur. The long-term goal is to develop a pharmacologic strategy to treat oculomotor movement disorders of the eyes. I am investigating if muscle force can increase after treatment with various growth factors and ascertain if there are changes in motor neuron function within the CNS.
- Karen Mesce
- Teresa Nick
- Michael Georgieff
- Linda Mcloon
Courses Taken Beyond the Core Courses:
- MICA 8320 - Neurostatistics
- PHM 8481 - Advanced Neuropharmaceutics
- PHM 8120 - Readings in CNS Drug Delivery
- BIOC 8002 - Molecular Biology
- NSC 5202 - Theoretical Neuroscience
Conferences Attended and Presentations:
- Society for Neuroscience anual meeting- Fall 2009
- Gordon Research Conference on Eye Movements - Summer 2011
- Paul Letourneau
- Mike Mustari
- Teresa Nick
- Martin Wessendorf
Selected Publications and Presentations:
- McLoon LK, Willoughby CL, Anderson JS, Bothun ED, Stager D Jr, Felius J, Lee H, Gottlob I. Abnormally small neuromuscular junctions in the extraocular muscles from subjects with idiopathic infantile nystagmus and nystagmus associated with albinism. Invest. Ophthalmol. Vis. Sci. 2016;57:1912-1920.
- Willoughby CL, Fleuriet J, Walton MM, Mustari MJ, McLoon LK. Adaptability of the Immature ocular motor control system: Unilateral IGF-1 medial rectus Ttreatment. Invest Ophthalmol Vis Sci. 2015;56(6):3484-96.
- Willoughby CL, Fleuriet J, Walton MM, Mustari MJ, McLoon LK. Adaptation of slow myofibers: the effect of sustained BDNF treatment of extraocular muscles in infant nonhuman primates. Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3467-3483.
- Walton MM, Mustari MJ, Willoughby CL, McLoon LK. Abnormal activity of neurons in abducens nucleus of strabismic monkeys. Invest Ophthalmol Vis Sci. 2015;56:10-19. Highlighted article: Cullen K; IOVS 2015;56:20.
- McLoon LK, Willoughby CL, Andrade FH. Extraocular Muscles: Structure and Function. In: Craniofacial Muscles: A New Framework for Understanding the Effector Side of Craniofacial Muscles. Eds: LK McLoon, F Andrade. Springer, 2012; pp. 31-88.
- Hebert SL, Willoughby CL, Andrade FH, McLoon LK. Masticatory Muscles: Response to Neuromuscular Diseases and Specific Pathologies. In: Craniofacial Muscles: A New Framework for Understanding the Effector Side of Craniofacial Muscles. Eds: LK McLoon, F Andrade. Springer, 2012.
- Willoughby CL, Christiansen SP, Mustari MJ, McLoon LK. Effects of sustained release of IGF-1 on extraocular muscle of the non-human primate: Adaptations at the effector organ level. Invest Ophthalmol Vis Sci. 2012;53:68-75.
- Willoughby CL, Ralles S, Christiansen SP, McLoon LK. Effects of sequential injections of hepatocyte growth factor and insulin-like growth factor-1 on adult rabbit extraocular muscle. J AAPOS. 2012;16(4):354-60.
- Willoughby CL, Christiansen SP, Mustari MJ, McLoon LK, 2011, "Effect of Sustained Release IGF-1 on Extraocular Muscle of the Non-Human Primate: Adaptations at the Effector Organ Level," Young Investigator Talk, Gordon research Conference on Eye Movements, Biddeford MN.
Awards and Honors:
- National Eye Institute of the NIH, Plexon and Blackrock Travel Fellowship, 2011
- Young Investigator Talk, Gordon Conference on Eye Movements, 2011
- Overland Park, Kansas