Meredith Noetzel

Ph.D. 2009

Thesis Title:

The action of xanomeline on human muscarinic receptors expressed in Chinese
hamster ovary cells

Current Position:

Senior Regulatory Affairs Specialist, Lutonix, Inc., New Hope, MN

Past Position(s):

Quality and Regulatory Affairs Manager, Insight Genetics Inc., Nashville, TN

Undergraduate Institution and Major/Degree:

University of Minnesota-Morris, BA, Biology and Chemistry, 2003

Major Advisor(s):

Esam El-Fakahany, Ph.D.

Lab Rotations:

  • Esam El-Fakahany
  • Walter Low
  • Laura Ranum

Courses Taken Beyond the Core Courses:

  • MICAB 8001 Integrated topics in microbiology, immunology and cancer biology
  • PHCL 5110 Introduction to pharmacology
  • PHCL 5111 - Pharmacogenomics
  • PHCL 8110 - Advanced Pharmacology
  • NSC 8221 - Neurobiology of pain
  • GRAD 8200 - Teaching & Learning in Higher Ed ucation – Beyond the Academy: Practical Job Search Strategies for Ph.D.s
  • OBIO 8022 - Oral Neuroscience
  • OBIO 8030 - Oral Biology Seminar

Graduate Level Minor:

  • Supporting program with an emphasis on pharmacology

Conferences Attended and Presentations:

  • Society for Neuroscience annual meeting - Fall 2004, 2005, 2006, 2007

Committee Members:

  • Bill Engeland (chair)
  • Ginger Seybold
  • Ping Law
  • Esam El-Fakahany (advisor)

Awards and Honors:

  • Biomedical Engineering Institute Fellowship 2005-06
  • National Institutes of Health – Minnesota Craniofacial Research Training Program Fellowship (2006 to present)

Publications:

  • Rook* JM, Noetzel* MJ, Pouliotn WA, Bridges TM, Vinson PN, Cho HP, Zhou Y, Gogliotti RD, Manka JT, Gregory KJ, Stauffer SR, Dudek FE, Xiang Z, Niswender CM, Daniels JS, Jones CK, Lindsley CW, Conn PJ. Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity. Biol Psychiatry. 2013;73(6):501-9.
  • Gregory KJ, Noetzel MJ, Rook JM, Vinson PN, Stauffer SR, Rodriguez AL, Emmitte KA, Zhou Y, Chun AC, Felts AS, Chauder BA, Lindsley CW, Niswender CM, Conn PJ.. Investigating mGlu5 allosteric modulator cooperativity, affinity and agonism: enriching structure-function studies and SAR. Mol Pharmacol. 2012 Nov;82(5):860-75.
  • Manka J, Zhou Y, Chun A, Dawson ES, Vinson PN, Niswender CM, Noetzel MJ, Rook JM, Bridges TM, Daniels JS, Jones C, Conn PJ, Lindsley CW, Stauffer SR. Identification of a selective allosteric agonist of mGlu5. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2011 Dec 16 [updated 2013 Mar 7].
  • Digby GJ, Noetzel MJ, Bubser M, Utley TJ, Walker AG, Byun NE, Lebois EP, Xiang Z, Sheffler DJ, Cho HP, Davis AA, Nemirovsky NE, Mennenga SE, Camp BW, Bimonte-Nelson HA, Bode J, Italiano K, Morrison R, Daniels JS, Niswender CM, Olive MF, Lindsley CW, Jones CK, Conn PJ. Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animals models. J Neurosci. 2012;20:8532-8544.
  • Melancon BJ, Lamers AP, Bridges TM, Sulikowski GA, Utley TJ, Sheffler DJ, Noetzel MJ, Morrison RD, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Wood MR. Development of a more highly selective M1 antagonist from the continued optimization of the MLPCN probe ML012. Bioorg Med Chem Lett. 2012;22(2):1044-8
  • Noetzel MJ, Rook JM, Vinson PN, Cho HP, Days E, Zhou Y, Rodriguez AL, Lavreysen H, Stauffer SR, Niswender CM, Xiang Z, Daniels JS, Jones CK, Lindsley CW, Weaver CD, Conn PJ. Functional impact of allosteric agonist activity of selective positive allosteric modulators of mGlu5 in regulating CNS function. Mol Pharmacol. 2012;81(2):120-33.
  • Grant MK, Noetzel MJ, De Lorme KC, Jakubík J, Doležal V, El-Fakahany EE.  Pharmacological evaluation of the long-term effects of xanomeline on the M1 muscarinic acetylcholine receptor. PLoS One. 2010 Dec 23;5(12):e15722.
  • Bridges TM, Phillip Kennedy J, Noetzel MJ, Breininger ML, Gentry PR, Conn PJ, Lindsley CW. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead.  Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett. 2010;20:1972-5
  • Noetzel MJ, Grant MK, El-Fakahany EE. Mechanisms of M3 muscarinic receptor regulation by wash-resistant xanomeline binding. Pharmacology. 2009;83(5):301-17.
  • Noetzel MJ, Grant MK, El-Fakahany EE. Immediate and delayed consequences of xanomeline wash-resistant binding at the M3 muscarinic receptor. Neurochem Res. 2009;34(6):1138-49.

Professional Memberships:

  • Society for Neuroscience

Home Town

  • Spring Lake Park , MN
Meredith Noetzel