Hippocampal Representations on the Spatial Delay Discounting Task
Undergraduate Institution and Major/Degree:
Juniata College, B.S., Physics, 2004
Postdoctoral Fellow, University of Pittsburgh
I study the choice behavior of rats while they make simple decisions to obtain food rewards. The choices made involve evaluation of a trade-off between amount of food and the time spent waiting before it is available. I have found that rats consistently choose to wait for a preferred time period, and its duration depends on the amount of food available. Before making decision that cause a change in the waiting period, rats frequently pause and reorient from one food option to the other.
Previous studies in the lab suggest that a neural search mechanism occurs when rats pause and reorient before making a choice. To investigate this mechanism, I am recording from the hippocampus, a brain structure known to be involved in spatial navigation and memories of event sequences. We think that a hippocampal search process may involve generation of place-related sequences projecting from the current position of the rat to positions of potential reward locations. This information could, presumably, assist in evaluation of the choices that are currently available. We hypothesize search is necessary for choice of a delayed food option compared to an immediately available alternative. In general, neural search may be involved in evaluation of decisions having long-term impact.
- Matthew Chafee
- Theoden Netoff
- A. David Redish
Courses Taken Beyond the Core Courses:
- NSC 5202 Theoretical Neuroscience
- PHSL 5201 Computational Neuroscience
- PSY 5012 Learning/Cognition in Animals
- Mathew Chafee (chair)
- James Ashe
- Angus MacDonald III
- A. David Redish
Conferences Attended and Presentations:
- Society for Neuroscience - 2008, 2009, 2010, 2012
- University of Minnesota Design of Medical Devices conference - Spring 2012
Selected Publications and Presentations:
- Papale AE, Zielinski MC, Frank LM, Jadhav SP, Redish AD. Interplay between hippocampal sharp-wave-ripple Eevents and vicarious trial and error behaviors in decision making. Neuron. 2016;92(5):975-982.
- Schmidt B, Papale A, Redish AD, Markus EJ. Conflict between place and response navigation strategies: effects on vicarious trial and error (VTE) behaviors. Learn Mem. 2013;20(3):130-8.
- Papale AE, Stott JJ, Powell NJ, Regier PS, Redish AD. Interactions between Deliberation and Delay-Discounting in Rats. Cogn Affect Behav Neurosci. 2012;12(3):513-26
- Papale AE, Mork R, Boldt C, Jackson JC, Ferguson JE, Redish AD. Wireless Galvanic transmission through neural tissue via modulation of a carrier signal by a passive probe. J. Med. Devices. 2012; 6(1):017509-017509-1.
- Society for Neuroscience
- State College and Shaler, PA