Fatou Amar

Ph. D. 2015

E-MAIL: amarx005@umn.edu

Thesis Title:

Specific Alterations of Tau Phosphorylation and Neuronal Signaling Induced by the Amyloid-β Oligomer Aβ*56

Undergraduate Institution and Major/Degree:

  • CUNY Hunter College, BA, Psychology, 2010

Major Advisor(s):

Research Description:

For nearly a century, amyloid plaques have been thought to be the bioactive agents in Alzheimer’s disease (AD). However, numerous studies in the past decade have supported the notion that the soluble forms of the amyloid-β (Aβ) peptides, called Aβ oligomers, were responsible for AD-associated memory impairment. I am interested in the molecular mechanism by which Aβ leads to the neuropathology that leads to the cognitive decline in AD. In particular, the oligomer Aβ*56 (a 56KDa oligomer of Aβ) was found to cause cognitive decline in the AD mouse model Tg2576 in absence of plaques and neuronal loss. How Aβ*56 is able to disrupt cognition at the cellular level remains unknown to this date. My current focus is to identify the molecular mechanism by which Aβ*56 is causing cognitive impairment in what seems to be preclinical AD.

Lab Rotations:

  • Michael Lee
  • Sylvain Lesne
  • Lorene Lanier
  • Yashushi Nakagawa

Courses Taken Beyond the Core Courses:

  • Neurobiology of Diseases
  • Signal Transduction/Gene Expression

Committee Members:

  • Michael Lee-Chair
  • Sylvain Lesne-Advisor
  • Karen Ashe
  • Harry Orr
  • Eric Newman
  • Dominic Walsh-External Member

Conferences Attended:

  • Society for Neuroscience meeting 2011 & 2014

Selected Publications:

  • F. Amar, Mathew A. Sherman, Travis J. Rush, Megan Larson, Julie A. Schneider, David A. Bennett, Karen H. Ashe, Alain Buisson & Sylvain E. Lesné, 2015 "Specific alterations of tau phosphorylation and neuronal signaling induced by the amyloid-β oligomer Aβ*56", Nature Neuroscience. (Under review)
  • M.E. Larson, M.A. Sherman, F. Amar, M. Nuvolone, J.A. Schneider, D.A. Bennett, A. Aguzzi and S.E. Lesne, "The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease." J. Neurosci

Awards and Honors:

  • Roth-Steer Award for Research in Alzheimer's Disease, 2015
  • American Legion Family Brain Sciences Student Award, 2014
  • Community of Scholars Program Travel Award, 2014
  • NIH T32 Training Grant 2012/2013

Home Town:

  • Dakar, Senegal
Fatou Amar