Physiologic Oxygen Levels Induce a Novel Adjuvant, "Annexin II": Implications for Brain Tumor Vaccines
Neurology Resident Physician, NewYork-Presbyterian Hospital/Weill-Cornell Medical Center
Undergraduate Institution and Major/Degree:
B.A. Chemistry, May 2005, St. Olaf College, Northfield, MN
- Walter Low, Ph.D.
- Michael Olin
Weill Cornell Medical Center, Neurology, New York
Malignant gliomas are aggressive neoplasms that respond poorly to surgery, radiation, and chemotherapy. Glioblastoma multiforme (WHO grade IV) kills roughly 70% of patients within two years of diagnosis. Immunotherapy holds great promise as a cell-specific, non-invasive approach, as shown in many phase I clinical trials.
We have increased the effectiveness of our vaccines derived from tumor cultures by placing them in a physiologic oxygen environment. This decrease in oxygen (from atmospheric O2, 20.95% to 5%) enriches the expression of annexin A2 in gliomas. Annexin A2 has immune adjuvant activity, and my thesis project involves understanding annexin A2's activation of dendritic cells, which initiate anti-glioma CD8 T cell responses.
- Walter Low
- Karen Ashe
- Kevin Wickman
Courses Taken Beyond the Core Courses:
- MICA 8011 Current Topics in Immunology
- PUBH 6414 Biostatistical Methods I
- MICA 8004 Cancer and Cell Biology
- MICA 8013 Translational Cancer Research
Graduate Level Minor:
- Olin MR, Pluhar GE, Andersen BM, Shaver R, Waldron NN, Moertel CL. Victory and defeat in the induction of a therapeutic response through vaccine therapy for human and canine brain tumors: a review of the state of the art. Crit Rev Immunol. 2014;34(5):399-432.
- Moertel CL, Xia J, LaRue R, Waldron NN, Andersen BM, Prins RM, Okada H, Donson AM, Foreman NK, Hunt MA, Pennell CA, Olin MR. CD200 in CNS tumor-induced immunosuppression: the role for CD200 pathway blockade in targeted immunotherapy. J Immunother Cancer. 2014 Dec 16;2(1):46. doi: 10.1186/s40425-014-0046-9. eCollection 2014.
- Andersen BM, Pluhar GE, Seiler CE, Goulart MR, Santacruz KS, Schutten MM, Meints JP, O'Sullivan MG, Bentley RT, Packer RA, Thomovsky SA, Chen AV, Faissler D, Chen W, Hunt MA, Olin MR, Ohlfest JR.Vaccination for Invasive Canine Meningioma Induces In Situ Production of Antibodies Capable of Antibody-Dependent Cell-Mediated Cytotoxicity. Cancer Res. 2013 May 15;73(10):2987-2997. PMCID: PMC3655124
- MR Olin, BM Andersen, DM Zellmer, PT Grogan, F Popescu, Z Xiong, CL Forster, C Seiler, KS SantaCruz, W Chen, BR Blazar, JR Ohlfest. Oxygen Regulates Tumor Cell Immunogenicity. Clinical Cancer Research. 2010 Oct 1;16(19):4800-8. PMID:20858839
- MR Olin, BM Andersen, AJ Litterman, PT Grogan, AL Sarver, PT Robertson, X Liang, W Chen, IF Parney, MA Hunt, BR Blazar, JR Ohlfest. “Oxygen is a Master Regulator of the Immunogenicity of Primary Human Glioma Cells. Cancer Research. 2011 Nov 1; 71(21):6583-9. Epub 2011 Sep 9. PMID: 21908554
- Walter Low
- David Largaespada
- Bruce Blazar
- Dan Kaplan
Conferences Attended and Presentations:
- American Academy of Neurology, Spring 2008
- Society for Neuroscience Annual Meeting, Fall 2009
- Society for Neuro-Oncology Annual Meeting, Fall 2010
Awards and Honors:
- Torske Klubben Fellowship for Minnesota Residents (2009-2011)
- Cancer Biology Training Grant (2011-)
- American Association of Cancer Research, Associate, 2012
- Spring, TX