Laura Stone

Ph.D. 1999

Thesis Title:

Alpha-2 Adrenergic Receptor Subtypes in Pain and Analgesia

Current Position:

Associate Professor
Faculty of Dentistry, Alan Edwards Centre for Research on Pain
McGill University Montreal, Quebec, Canada

Major Advisor(s):

Selected Publications:

  • Schuster DJ, Kitto KF, Overland AC, Messing RO, Stone LS, Fairbanks CA, Wilcox GL. Protein kinase Cε is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs. J Neurosci. 2013 Aug 14;33(33):13538-46.
  • M. Millecamps, M. Tajerian, L. Naso, L.S Stone; Lumbar Intervertebral Disc Degeneration Associated with Axial and Radicular Low Back Pain in Aging SPARC-null Mice; Pain, 2012; 153(6):1167-79. http://www.ncbi.nlm.nih.gov/pubmed/22414871
  • M. Tajerian, M. Millecamps, L.S Stone; Morphine and Clonidine Synergize to Ameliorate Low Back Pain in Mice; Pain Research and Treatment, Volume 2012, Article ID150842. http://www.ncbi.nlm.nih.gov/pubmed/22414871
  • N. Audet, O. Mnie-Filali, M. Amraei, A-J. Chabot-Doré, M. Millecamps, L.S. Stone and G. Pineyro; Differential Association of Receptor-Gβγ Complexes with β-arrestin2 Determines Recycling Bias and Potential for Tolerance of Delta Opioid Receptor (DOR) Agonists; J Neuroscience, 32(14):4827– 4840, 2012.
  • M. Tajerian, S. Alvarado, M. Millecamps, T. Dashwood, K.M. Anderson, L. Haglund, J.A. Ouellet, M. Szyf, L.S Stone; DNA Methylation of SPARC is Associated with Low Back Pain; Molecular Pain, 7(1):65, 2011.
  • D.A. Seminowicz, T.H. Wideman, L. Naso, Z. Hatami-Khoroushahi, S. Fallatah, M. Ware, P. Jarzem, M.C. Bushnell, Y Shir, J.A. Ouellet, and L.S. Stone; Effective Treatment of Chronic Low Back Pain Reverses Structural and Functional Brain Changes; Journal of Neuroscience, 31(20):7540-7550, 2011.
  • F.J. Symons, J.J. Wolff, L.S. Stone, T. Lim and J.W. Bodfish; Salivary Biomarkers of HPA Axis and Autonomic Activity in Adults with Intellectual Disability With and Without Stereotyped and Self-Injurious Behavior Disorders; Journal of Neurodevelopmental Disorders: 3(2):144-151, 2011.
  • M. Millecamps, M. Tajarian, E.H. Sage, and L.S. Stone; Behavioral Signs of Chronic Back Pain in the SPARC-null mouse; Spine, 36(2):95-102, 2011 (NIHMS221485, CAPMC1525).
  • A.C. Overland, K.F. Kitto, A.J. Chabot-Dore, P.E. Rothwell, C.A. Fairbanks, L.S. Stone, G.L. Wilcox. 2009. Protein Kinase C Mediates the Synergistic Interaction Between Agonists Acting at Alpha-2-Adrenergic and Delta-Opioid Receptors in Spinal Cord. Journal of Neuroscience, 29(42):13264-13273, 2009.
  • M.S. Riedl, S. Schnell, A.C. Overland, A-J. Chabot-Dore, A.M. Taylor, A. Ribeiro-Da-Silva, R. Elde, G.L. Wilcox and L.S. Stone. 2009. Co-expression of Alpha-2a-adrenergic and delta-opioid receptors in Substance P terminals in rat dorsal horn. Journal of Comparative Neurology 513(4):385-398; 2009 (NIHMS89435).
  • C.A. Fairbanks, K.F. Kitto, H.O. Nguyen, L.S. Stone, and G.L. Wilcox. 2009. Clonidine and Dexmedetomidine Produce Antinociceptive Synergy in Mouse Spinal Cord. Anesthesiology 110(3):638-47; 2009.
  • J. Lai, M. Riedl, L.S. Stone, U. Arvidsson, E.J. Bilksy, G.L. Wilcox, R. Elde and F. Porreca; Immunofluorescence Analysis of Antisense Oligo-deoxynucleotide-Mediated Knock-Down of the -Opioid Receptor in Vitro an in Vivo; Neuroscience  Letters  213:205-208; 1996. 
  • Stone LS, MacMillan LB, Kitto KF, Limbird LE, Wilcox GL. (1997) The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci. Sep 15;17(18):7157-65.
  • Stone LS, Fairbanks CA, Laughlin TM, Nguyen HO, Bushy TM, Wessendorf MW, Wilcox GL. (1997) Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2. Neuroreport. Sep 29;8(14):3131-5. 
  • Stone LS, Broberger C, Vulchanova L, Wilcox GL, Hokfelt T, Riedl MS, Elde R. (1998) Differential distribution of alpha2A and alpha2C adrenergic receptor immunoreactivity in the rat spinal cord. J Neurosci. Aug 1;18(15):5928-37. 
  • Vulchanova L, Riedl MS, Shuster SJ, Stone LS, Hargreaves KM, Buell G, Surprenant A, North RA, Elde R. (1998) P2X3 is expressed by DRG neurons that terminate in inner lamina II. Eur J Neurosci. Nov;10(11):3470-8. 
  • Stone LS, Vulchanova L, Riedl MS, Wang J, Williams FG, Wilcox GL, Elde R. (1999) Effects of peripheral nerve injury on alpha-2A and alpha-2C adrenergic receptor immunoreactivity in the rat spinal cord. Neuroscience. 93(4):1399-407. 
  • Fairbanks CA, Posthumus IJ, Kitto KF, Stone LS, Wilcox GL. (2000) Moxonidine, a selective imidazoline/alpha(2) adrenergic receptor agonist, synergizes with morphine and deltorphin II to inhibit substance P-induced behavior in mice. Pain. Jan;84(1):13-20. 
  • Fairbanks CA, Schreiber KL, Brewer KL, Yu CG, Stone LS, Kitto KF, Nguyen HO, Grocholski BM, Shoeman DW, Kehl LJ, Regunathan S, Reis DJ, Yezierski RP, Wilcox GL.  (2000) Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury. Proc Natl Acad Sci U S A. Sep 12;97(19):10584-9. 
  • Vulchanova L, Olson TH, Stone LS, Riedl MS, Elde R, Honda CN. (2001) Cytotoxic targeting of isolectin IB4-binding sensory neurons. Neuroscience. 108(1):143-55.
  • Guo A, Simone DA, Stone LS, Fairbanks CA, Wang J, Elde R. (2001) Developmental shift of vanilloid receptor 1 (VR1) terminals into deeper regions of the superficial dorsal horn: correlation with a shift from TrkA to Ret expression by dorsal root ganglion neurons. Eur J Neurosci. Jul;14(2):293-304. 
  • Fairbanks CA, Stone LS, Kitto KF, Nguyen HO, Posthumus IJ, Wilcox GL. (2002) alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J Pharmacol Exp Ther. Jan;300(1):282-90.

Honors and Awards:

Laura Stone