Stem Cells in Ischemic Brain Injury
Resident, Neurological Surgery, School of Medicine, Stanford University
Undergraduate Institution and Major/Degree:
Columbia Union College, Takoma Park, BS in Biology and Biochemistry
- Walter C. Low, Ph.D.
- Catherine Verfaillie, M.D.
My current interests include the ability of Multipotent Adult Progenitor Cells from bone marrow to generate neurons in vitro and in vivo, and their behavior in a mouse model of stroke. Although neural differentiation of bone marrow-derived cells is highly controversial, preliminary evidence suggests that MAPCs have certain properties of embryonic stem cells, and may be capable of neural differentiation, though further work is needed to confirm this. In the injured brain, MAPCs migrate robustly toward areas of ischemia where they proliferate to replace the infarct area. The functional implications and mechanisms of this behavior are under investigation. Additional interests include the behavior of endogenous neural stem cells, and the potential to mobilize these for treatment of CNS injury or degeneration.
Conferences Attended and Presentations:
- Society for Neuroscience: 2003, 2005
- American Society for Nuerochemistry, Madison, WI, June 28, 2005
- Nigro AL, Geraerts M, Notelaers T, Roobrouck VD, Muijtjens M, Eggermont K, Subramanian K, Ulloa-Montoya F, Park Y, Owens J, Burns TC, Low W, Sharma S, Sohni A, Crabbe A, Pauwelyn K, Roelandt P, Agirre X, Prosper F, O’Brien TD, Zwijsen A, Hu W-S, Binas B, Verfaillie CM. MAPC culture conditions support the derivation of cells with nascent hypoblast features from bone marrow and blastocysts. Journal of Molecular Cell Biology 2012 (In press)
- Joshua J. Loya, Katie McKenzie, Stephan Mindea, Hong Yu, Chitra Venkatasubramanian, Anand Veeravagu, Steven Chang, Terry C. Burns. Intracranial Hypotension Producing Reversible Coma: A Systematic Review, Including Four New Cases. Journal of Neurosurgery 2012 (In Press)
- Stefan A. Mindea, Terry C. Burns, Nicolae B. Lapustea, Jayakar Nayak, Transnasal Approach for Treatment of Osteomyelitis at the Craniocervical Junction (Submitted)
- Terry Burns, Joshua J Loya, Harman Singh, Images in Neurosurgery: Neurocysticercosis. CNS Congress Quarterly, Winter 2012 (Accepted)
- Nadia Khan, Achal S Achrol, Terry C. Burns, Raphael Guzman, Robert Dodd, Teresa Bell-Stephens, Gary Steinberg. Gender Differences in Clinical Presentation and Treatment Outcomes in Moyamoya Disease. (Accepted)
- Terry C. Burns, Gary K. Steinberg. Stem Cell Therapy for Stroke. Expert Opinion of Biological Therapy, 2011. 11(4):447-61
- Kenneth W. Dodd*, Terry C. Burns*, Stephen M. Wiesner, Elina Kudishevich, Dominic T. Schomberg, Bo-Woo Jung, Ji-Eun Kim, John R Ohlfest, Walter C. Low. Transgenic mice expressing luciferase under a 4.5 kb tyrosine hydroxylase promoter. PEEReMED. 2011.
- Benjamin L. Kidder, Bipasha Bose, Terry C. Burns, Catherine M. Verfaillie. ECAT1 Transcriptional Silencing does Not Affect Embryonic Stem Cell Pluripotency. (In Revision)
- Terry Burns, David Power, John O. Neher. Risk Factors for Carotid and Vertebral Artery Dissection. Evidence-Based Practice. 2009: 12(3) 8.
- Terry C. Burns, Catherine Verfaillie, Walter Low. Stem Cells for Ischemic Brain Injury: A Critical Review. Journal of Comparative Neurology. 2009: 515(1):125-44.
Awards and Honors:
- Selected to participate in Route28 summit in neurobiology, Germany (2007)
- Doctoral Dissertation Fellowship, University of Minnesota (2006-2007)
- American Society for Neural Therapy and Repair Travel Award (2006)
- Hough Parkinson's Grant Recipient - $63,000 (2005-2006)
- Society For Neuroscience Predoctoral Travel Award (2005)
- BMEI Tissue Engineering Fellowship (2004-2005)
- Smithberg Memorial Prize for outstanding achievement in neuroscience (2004)
- Chancellor's List (Who's Who Among Graduate Students; 2004, 2005)
- 3M Science and Technology fellowhip (2003-2007)
- Glenelg, NSW Australia