Neural adaptations following exposure to HIV proteins
Undergraduate Institution and Major:
University of Illinois, B.S. in Molecular and Cellular Biology, 2012
Stanley Thayer, Ph.D., Department of Pharmacology
Thesis Committee Members:
- Paul Mermelstein, Ph.D., Department of Neuroscience (Chair)
- Tay Netoff, Ph.D., Department of Biomedical Engineering
- Stan Thayer, Ph.D., Department of Pharmacology
- Kevin Wickman, Ph.D., Department of Pharmacology
Description of Graduate Research:
My thesis work aims to delineate some of the mechanisms for changes in neuronal networks during prolonged exposure to neurotoxic HIV proteins, such as HIV-1 Tat. Specifically, I am looking at how NMDAR function changes during prolonged exposure to these proteins. My research has shown that different NMDAR subtypes differentially regulate adaptations of neural networks during exposure to Tat. I primarily use electrophysiological techniques to study NMDARs in vitro, and will be developing in vivo assays to study how neural networks adapt to Tat as well.
- Neurodegenerative Diseases and Neural Injury
- Synaptic Plasticity and Learning
- Green MV, Raybuck JD, Zhang X, Wu MM, Thayer SA. Scaling synapses in the presence of HIV. Neurochem Res. 2019;44(1):234-246.
- Green MV, Thayer SA. NMDARs adapt to neurotoxic HIV protein Tat downstream of a GluN2A-ubiquitin ligase signaling pathway. J Neurosci. 2016;36:12640-12649.
- Ghosh B, Green MV, Krogh KA, Thayer SA. Interleukin-1β activates a Src family kinase to stimulate the plasma membrane Ca2+ pump in hippocampal neurons. J Neurophysiol. 2016;115:1875-1885.
- Krogh KA, Green MV, Thayer SA. HIV-1 tat-induced changes in synaptically-driven network activity adapt during prolonged exposure. Curr HIV Res. 2014;12:406-414.
- Green MV, Thayer SA. (2015) Adaptation of synaptic NMDARs during HIV Tat-induced neurotoxicity. Society for Neuroscience 2015, Chicago.
- Tim Ebner, M.D., Ph.D., Department of Neuroscience
- Mark Thomas, Ph.D., Department of Neuroscience
- Stanley Thayer, Ph.D., Department of Pharmacology
- Society for Neuroscience, 2012-present