David Linden

Ph.D. 1999

Thesis Title:

The Role of Spinal Neurokinin 3 Receptors in Processing Nociceptin Information

Current Position:

Assistant Professor of Physiology, College of Medicine, Mayo Clinic School of Medicine

Associate Consultant, Department of Physiology & Biomedical Engineering
Mayo Clinic, Rochester, Minnesota

Major Advisor(s):

Virginia Seybold, Ph.D.

Selected Publications:

  • Linden DR, El-Fakahany EE. Microglial derived nitric oxide decreases serotonin content in rat basophilic leukemia (RBL-2H3) cells. Eur J Clin Pharmacol. 2002;436:53-6.
  • Linden DR, El-Fakahany EE. Arachidonic acid inhibition of muscarinic receptor-mediated nitric oxide production occurs at the level of calcium mobilization in Chinese hamster ovary cells. Neurochem Res. 2002;27:441-9.
  • Linden DR, Chell MJ, El-Fakahany EE, Seybold VS. Neurokinin3 receptors couple to the activation of neuronal nitric oxide synthase in stably transfected Chinese hamster ovary cells. J Pharmacol Exp Ther. 2000; 293:559-568.
  • Linden DR, Reutter MA, McCarson KE, Seybold VS. Time-dependent changes in neurokinin3 receptors and tachykinins during adjuvant-induced peripheral inflammation. Neuroscience. 2000; 98:801-811.
  • Linden DR, Seybold VS. Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide. Pain. 1999;80:309-317.
  • Linden DR, Jia YP, Seybold VS. Spinal neurokinin3 receptors facilitate the nociceptive flexor reflex via a pathway involving nitric oxide. Pain. 1999;80:301-308.
  • Jia YP, Linden DR, Serie JR, Seybold VS. Nociceptin/orphanin FQ binding increases in superficial laminae of the rat spinal cord during persistent peripheral inflammation. Neurosci Lett. 1998;250:21-24.

Honors and Awards:

  • Bacaner Award
David Linden