Quantification of uncertainty in DTI tractography of cerebral white matter
Resident, Neurology, University of California - Los Angeles
We are investigating white matter pathology and physiology using magnetic resonance diffusion tensor imaging (DTI) in neuropsychiatric disease populations, including schizophrenia, cocaine addiction, fetal alcohol syndrome, diabetes mellitus and myotonic dystrophy. White matter integrity is additionally being investigated in animal models of these diseases at high magnetic field using diffusion-weighted imaging sequences that we are currently developing.
In order to better understand the nature of the MR diffusion-weighted signal, we are modeling the effects of noise and MRI acquisition parameters on the diffusion signal.
- Karen Ashe
- Walter Low
- Kelvin Lim
Graduate Level Minor:
- Kodl CT, Franc DT, Rao JP, Anderson FS, Thomas W, Mueller BA, Lim KO, Seaquist ER. Diffusion Tensor Imaging (DTI) identifies deficits in white matter microstructure in subjects with type 1 diabetes mellitus that correlate with reduced neurocognitive function. Diabetes. 2008 Aug 11.
- Lim KO, Wozniak JR, Mueller BA, Franc DT, Specker SM, Rodriguez CP, Silverman AB, Rotrosen JP. Brain macrostructural and microstructural abnormalities in cocaine dependence. Drug Alcohol Depend. 2008 Jan 1;92(1-3):164-72. Epub 2007 Sep 29.
Awards and Honors:
- Neuro-Physical Computational Science NIH Predoctoral Training Program, 2006-2007
- Knoxville, Iowa