Dan Franc

Ph. D. 2008

Thesis Title:

Quantification of uncertainty in DTI tractography of cerebral white matter

Current Position:

Resident, Neurology, University of California - Los Angeles

Major Advisor(s):

Kelvin O. Lim, M.D.

Research Description:

We are investigating white matter pathology and physiology using magnetic resonance diffusion tensor imaging (DTI) in neuropsychiatric disease populations, including schizophrenia, cocaine addiction, fetal alcohol syndrome, diabetes mellitus and myotonic dystrophy. White matter integrity is additionally being investigated in animal models of these diseases at high magnetic field using diffusion-weighted imaging sequences that we are currently developing.
In order to better understand the nature of the MR diffusion-weighted signal, we are modeling the effects of noise and MRI acquisition parameters on the diffusion signal.

Lab Rotations:

  • Karen Ashe
  • Walter Low
  • Kelvin Lim

Graduate Level Minor:

  • Medicine

Selected Publications:

  • Kodl CT, Franc DT, Rao JP, Anderson FS, Thomas W, Mueller BA, Lim KO, Seaquist ER. Diffusion Tensor Imaging (DTI) identifies deficits in white matter microstructure in subjects with type 1 diabetes mellitus that correlate with reduced neurocognitive function. Diabetes. 2008 Aug 11.
  • Lim KO, Wozniak JR, Mueller BA, Franc DT, Specker SM, Rodriguez CP, Silverman AB, Rotrosen JP. Brain macrostructural and microstructural abnormalities in cocaine dependence. Drug Alcohol Depend. 2008 Jan 1;92(1-3):164-72. Epub 2007 Sep 29.

Awards and Honors:

  • Neuro-Physical Computational Science NIH Predoctoral Training Program, 2006-2007

Home Town:

  • Knoxville, Iowa
Dan Franc