Virginia Goettl

DVM/Ph.D. 1996

Thesis Title:

The effects and mechanisms of action of the substance P N-terminus on nociceptive transmission in the spinal cord

Current Position:

Research Associate, Comprehensive Cancer Center, The Ohio State University

Major Advisor(s):

Alice Larson, Ph.D.

Selected Publications:

  • Goettl VM, Larson AA. An antagonist of substance P N-terminal fragments, D-substance P(1-7), reveals that both nociceptive and antinociceptive effects are induced by substance P N-terminal activity during noxious chemical stimulation. Brain Res. 1998;780(1):80-5.
  • Goettl VM, Larson DL, Portoghese PS, Larson AA. Inhibition of substance P release from spinal cord tissue after pretreatment with capsaicin does not mediate the antinociceptive effect of capsaicin in adult mice. Pain. 1997;71(3):271-8.
  • Goettl VM, Larson AA. Nitric oxide mediates long-term hyperalgesic and antinociceptive effects of the N-terminus of substance P in the formalin assay in mice. Pain. 1996 Oct;67(2-3):435-41.
  • Goettl VM, Xu XJ, Larson AA, Wisenfeld-Hallin Z. Substance P N-terminus inhibits C-fiber-dependent facilitation of the rat flexor reflex. Eur J Pharmacol. 1994;259(1):83-6.
  • Goettl VM, Larson AA. Activity at phencyclidine and mu opioid sites mediates the hyperalgesic and antinociceptive properties of the N-terminus of substance P in a model of visceral pain. Neuroscience. 1994;60(2):375-82.
  • Goettl VM, Larson AA. Antinociception induced by 3-((+-)-2-carboxypiperazin-4-yl)-propyl-1- phosphonic acid (CPP), an N-methyl-D-aspartate (NMDA) competitive antagonist, plus 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist, differs from that induced by MK-801 plus DNQX. Brain Res. 1994;642(1-2):334-8.
Virginia Goettl