Suhasa Kodandaramaiah, Ph.D.

Assistant Professor, Department of Mechanical Engineering

E-MAIL: suhasabk@umn.edu

 

Research Interests:

My research group at the University of Minnesota’s Mechanical Engineering department is focused on building novel neurotechnologies that help better understand how computations that occur in the brain drive mammalian behavior. Computations in the brain that mediate behavior occur at multiple spatial and temporal scales. Information is integrated in the brain within single cells, which are interconnected in dense local circuits, which are in turn, incorporated in larger networks spanning many brain regions. A critical challenge for modern neuroscience is to study the brain across these multiple spatial and temporal scales. Traditionally, the modalities used to observe activities at one level do not scale to the next level without loss of signal fidelity or information. My laboratory is combining expertise in robotics, precision engineering, optics and microfabrication for engineering novel technologies that seek to bridge these experimental scales. 


Selected Publications:

  • Holst GL, Stoy W, Yang B, Kolb I, Kodandaramaiah SB, Li L, Knoblich U, Zeng H, Haider B, Boyden ES, Forest CR. Autonomous patch clamp robot for functional characterization of neurons in vivo: development and application to mouse visual cortex. J Neurophysiol. 2019;121(6):2341-2357.
  • Shull G, Haffner C, Huttner WB, Kodandaramaiah SB, Taverna E. Robotic platform for microinjection into single cells in intact tissue. EMBO Rep. 2019 Aug 30:e47880.
  • Ghanbari L, Carter RE, Rynes ML, Dominguez J, Chen G, Naik A, Hu J, Sagar MAK, Haltom L, Mossazghi N, Gray MM, West SL, Eliceiri KW, Ebner TJ, Kodandaramaiah SB. Cortex-wide neural interfacing via transparent polymer skulls. Nat Commun. 2019 Apr 2;10(1):1500
  • Ghanbari L, Rynes ML, Hu J, Schulman DS, Johnson GW, Laroque M, Shull GM, Kodandaramaiah SB. Craniobot: A computer numerical controlled robot for cranial microsurgeries. Sci Rep. 2019 Jan 31;9(1):1023.
  • Allen BD, Moore-Kochlacs C, Bernstein JG, Kinney JP, Scholvin J, Seoane LF, Chronopoulos C, Lamantia C, Kodandaramaiah SB, Tegmark M, Boyden ES. Automated in vivo patch clamp evaluation of extracellular multielectrode array spike recording capability. J Neurophysiol. 2018;120(5):2182-2200.
  • Kodandaramaiah SB, Flores FJ, Holst GL, Singer AC, Han X, Brown EN, Boyden ES, Forest CR. Multi-neuron intracellular recording in vivo via interacting autopatching robots. Elife. 2018 Jan 3;7. pii: e24656.
  • Kolb I, Talei Franzesi G, Wang M, Kodandaramaiah SB, Forest CR, Boyden ES, Singer AC. Evidence for long-timescale patterns of synaptic inputs in CA1 of awake behaving mice, J Neurosci. 2018;38(7):1821-1834.
  • Piatkevich KD, Suk HJ, Kodandaramaiah SB, Yoshida F, DeGennaro EM, Drobizhev M, Hughes TE, Desimone R, Boyden ES, Verkhusha VV. Near-infrared fluorescent proteins engineered from bacterial phytochromes in neuroimaging. Biophys J. 2017 Nov 21;113(10):2299-2309.
  • Suk HJ, van Welie I, Kodandaramaiah SB, Allen B, Forest CR, Boyden ES. Closed-loop real-time imaging enables fully automated cell-targeted patch-clamp neural recording in vivo. Neuron. 2017 Sep 27;96(1):244-245.
  • Grossman N, Bono D, Dedic N, Kodandaramaiah SB, Rudenko A, Suk HJ, Cassara AM, Neufeld E, Kuster N, Tsai LH, Pascual-Leone A, Boyden ES. Noninvasive deep brain stimulation via temporally interfering electric fields.  Cell. 2017;169(6):1029-1041.
  • Singer AC, Talei Franzesi G, Kodandaramaiah SB, Flores FJ, Cohen JD, Lee AK, Borgers C, Forest CR, Kopell NJ, Boyden ES. Mesoscale-duration activated states gate spiking in response to fast rises in membrane voltage in the awake brain. J Neurophysiol. 2017;118(2):1270-1291.
  • Wu 吴秋雨 Q, Kolb I, Callahan BM, Su Z, Stoy W, Kodandaramaiah SB, Neve R, Zeng H, Boyden ES, Forest CR, Chubykin AA. Integration of autopatching with automated pipette and cell detection in vitro. J Neurophysiol. 2016;116(4):1564-1578.
  • Kodandaramaiah SB, Holst GL, Wickersham IR, Singer AC, Franzesi GT, McKinnon ML, Forest CR, Boyden ES. Assembly and operation of the autopatcher for automated intracellular neural recording in vivo. Nat Protoc. 2016;11(4):634-54.
  • Baratta MV, Kodandaramaiah SB, Monahan PE, Yao J, Weber MD, Lin PA, Gisabella B, Petrossian N, Amat J, Kim K, Yang A, Forest CR, Boyden ES, Goosens KA. Stress enables reinforcement-elicited serotonergic consolidation of fear memory. Biol Psychiatry. 2016;79(10):814-822.
  • Harrison RR, Kolb I, Kodandaramaiah SB, Chubykin AA, Yang A, Bear MF, Boyden ES, Forest CR. Microchip amplifier for in vitro, in vivo, and automated whole-cell patch-clamp recording. J Neurophysiol. 2015;113(4):1275-82.
  • Chuong AS, Miri ML, Busskamp V, Matthews GA, Acker LC, Sørensen AT, Young A, Klapoetke NC, Henninger MA, Kodandaramaiah SB, Ogawa M, Ramanlal SB, Bandler RC, Allen BD, Forest CR, Chow BY, Han X, Lin Y, Tye KM, Roska B, Cardin JA, Boyden ES. Noninvasive optical inhibition with a red-shifted microbial rhodopsin. Nat Neurosci. 2014;17(8):1123-1129.
  • Kodandaramaiah SB, Boyden ES, Forest CR. Boyden, In vivo robotics: Towards the automation of neuroscience and other intact-system biological fields. Ann N Y Acad Sci. 2013 Dec;1305:63-71.
  • Kodandaramaiah SB, Franzesi GT, Chow BY, Boyden ES, Forest CR. Automated whole-cell patch clamp electrophysiology of neurons in vivo. Nat Methods. 2012;9(6):585-587.
Picture of Suhasa Kodandaramaiah