Christina Pacak, PhD

Assistant Professor, Department of Neurology

E-MAILcpacak@umn.edu

Research Interests:

Christina Pacak joined the University of Minnesota faculty as an Assistant Professor in the Neurology Department in Winter 2021. Her laboratory investigates mechanisms that lead to mitochondrial dysfunction in a variety of disease settings including cardiomyopathies, muscular dystrophies, and premature aging disorders associated with neurological dysfunction. Her research program uses differentiated patient-derived induced pluripotent stem cells (iPSCs), and various in vivo models to test adeno-associated virus (AAV) mediated gene delivery systems.

Publications

  • Tsai AC, Pacak CA. Bioprocessing of human mesenchymal stem cells: From planar culture to microcarrier-based bioreactors. Bioengineering (Basel). 2021 Jul 7;8(7):96.
  • Li C, Vargas-Franco D, Saha M, Davis RM, Manko KA, Draper I, Pacak CA, Kang PB. Megf10 deficiency impairs skeletal muscle stem cell migration and muscle regeneration. FEBS Open Bio. 2021 Jan;11(1):114-123.
  • Watanabe N, Kitada K, Santostefano KE, Yokoyama A, Waldrop SM, Heldermon CD, Tachibana D, Koyama M, Meacham AM, Pacak CA, Terada N. Generation of induced pluripotent stem cells from a female patient with a Xq27.3-q28 deletion to establish disease models and identify therapies. Cell Reprogram. 2020 Aug;22(4):179-188.
  • Barton ER, Pacak CA, Stoppel WL, Kang PB.The ties that bind: functional clusters in limb-girdle muscular dystrophy. Skelet Muscle. 2020 Jul 29;10(1):22.
  • Suzuki-Hatano S, Saha M, Soustek MS, Kang PB, Byrne BJ, Cade WT, Pacak CA. AAV9-TAZ gene replacement ameliorates cardiac TMT proteomic profiles in a mouse model of Barth Syndrome. Molecular Therapy - Methods & Clinical Development, Volume 13, 2019, Pages 167-179, ISSN 2329-0501, https://doi.org/10.1016/j.omtm.2019.01.007.
Picture of Christina Pacak